2020
Inhaled multi-walled carbon nanotubes differently modulate global gene and protein expression in rat lungs
Seidel C, Zhernovkov V, Cassidy H, Kholodenko B, Matallanas D, Cosnier F, Gaté L. Inhaled multi-walled carbon nanotubes differently modulate global gene and protein expression in rat lungs. Nanotoxicology 2020, 15: 238-256. PMID: 33332178, DOI: 10.1080/17435390.2020.1851418.Peer-Reviewed Original ResearchConceptsNM-401Bronchoalveolar lavage fluidLong-term health effectsWeeks of inhalationDose-dependent increasePost-exposure timeLung inflammationLavage fluidWhole lungRat lungInhalationHealth effectsProtein expressionRecovery periodMechanisms of toxicityMWCNT exposureDifferent toxicological profilesLungToxicological profileDaysToxicological effectsPersistent effectsToxicityAnimalsToxicogenomic approach
2000
Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding.
Marcinkeviciute A, Mildaziene V, Crumm S, Demin O, Hoek J, Kholodenko B. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding. Biochemical Journal 2000, 349: 519-26. PMID: 10880351, PMCID: PMC1221175, DOI: 10.1042/0264-6021:3490519.Peer-Reviewed Original ResearchConceptsOxidative phosphorylationRespiratory fluxMitochondrial proton leakRat liver mitochondriaMitochondrial oxidative phosphorylationCytochrome c oxidaseMitochondrial energy metabolismATP synthaseLiver mitochondriaProton leakC oxidaseProtonmotive forceState 3Blocks of reactionsPhosphorylationEnergy metabolismMitochondriaMitochondrial malfunctioningRespiration rateRespiratory activityRespiratory subsystemIndividual functional unitsFunctional units
1999
Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor*
Kholodenko B, Demin O, Moehren G, Hoek J. Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor*. Journal Of Biological Chemistry 1999, 274: 30169-30181. PMID: 10514507, DOI: 10.1074/jbc.274.42.30169.Peer-Reviewed Original Research