Complexity of Receptor Tyrosine Kinase Signal Processing
Volinsky N, Kholodenko BN. Complexity of Receptor Tyrosine Kinase Signal Processing. Cold Spring Harbor Perspectives In Biology 2013, 5: a009043. PMID: 23906711, PMCID: PMC3721286, DOI: 10.1101/cshperspect.a009043.Peer-Reviewed Original ResearchMeSH KeywordsFeedback, PhysiologicalGene Expression Regulation, EnzymologicGene Regulatory NetworksModels, BiologicalReceptor Cross-TalkReceptor Protein-Tyrosine KinasesSignal TransductionSystems BiologyConceptsCombinatorial varietySignal processingMathematical modelingSpecific system propertiesSpecific cell fate decisionsSystem propertiesNetwork behaviorReceptor tyrosine kinasesMultiple feedsSpatiotemporal dynamicsComputational approachExcitable responseIntricate landscapeCell fate decisionsSpecific cellular outcomesPathway cross talkOscillationsBistabilityNetwork circuitryDynamicsModelingTranscriptional controlAdapts cellsCellular outcomes