2018
Reconstructing static and dynamic models of signaling pathways using Modular Response Analysis
Santra T, Rukhlenko O, Zhernovkov V, Kholodenko B. Reconstructing static and dynamic models of signaling pathways using Modular Response Analysis. Current Opinion In Systems Biology 2018, 9: 11-21. DOI: 10.1016/j.coisb.2018.02.003.Peer-Reviewed Original ResearchModular Response AnalysisNetwork reconstruction methodsPhysics-based methodBiochemical pathwaysBiological networksNetwork reconstructionTopological modelDynamic modelResponse analysisNetwork modulesCertain conditionsPathwayReconstruction methodMechanistic modelEntire networkModelCore theoryReformulationPerturbationsTheorySufficient numberNetworkGlobal responseDirection
1996
Steady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory
Cascante M, Puigjaner J, Kholodenko B. Steady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory. Journal Of Theoretical Biology 1996, 178: 1-6. DOI: 10.1006/jtbi.1996.0001.Peer-Reviewed Original ResearchMatrix equationBiochemical systems theorySingle matrix inversionLocal propertiesMatrix inversionSystems theoryLink matrixMetabolic control analysisControl propertiesEquationsMoiety conservationSensitivity theoryControl analysisTheoryStructural propertiesMatrixPropertiesState characterizationInversionControl of Dynamics and Steady State: Applications to Multidrug Resistance
Westerhoff H, Bier M, Molenaar D, Spoelstra E, Lankelma J, Jongsma A, Jensen P, Richard P, Kholodenko B. Control of Dynamics and Steady State: Applications to Multidrug Resistance. 1996, 25-31. DOI: 10.1007/978-3-322-85017-1_3.Peer-Reviewed Original Research