Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
Chatterjee S, Yabaji S, Rukhlenko O, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko B, Brown L, Beeler A, Ivanov A, Kobzik L, Porco J, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis. IScience 2021, 24: 102845. PMID: 34381970, PMCID: PMC8333345, DOI: 10.1016/j.isci.2021.102845.Peer-Reviewed Original ResearchMacrophage polarizationAlternative activation programChronic unresolved inflammationType 2 immunityCytokine IFN-gammaM1-like macrophagesM1-like phenotypeChronic bacterial infectionM2-like phenotypeUnresolved inflammationInfectious granulomasIL-4IFN-gammaPhagosome-lysosome fusionIntracellular mycobacteriaReparative microenvironmentHost immunityMacrophage phenotypeSolid tumorsTumor growthBacterial infectionsCertain tumorsTumor progressionType 1Primary macrophages