‘Channelled’ pathways can be more sensitive to specific regulatory signals
Kholodenko B, Demin O, Westerhoff H. ‘Channelled’ pathways can be more sensitive to specific regulatory signals. FEBS Letters 1993, 320: 75-78. PMID: 8462681, DOI: 10.1016/0014-5793(93)81661-i.Peer-Reviewed Original ResearchConceptsSpecific regulatory signalsEnzyme-enzyme interactionsRegulatory signalsMetabolic pathwaysExternal signalsReceptor enzymePathwayEnzymeThe sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two
van DAM K, van der VLAG J, KHOLODENKO B, WESTERHOFF H. The sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two. The FEBS Journal 1993, 212: 791-799. PMID: 8462550, DOI: 10.1111/j.1432-1033.1993.tb17720.x.Peer-Reviewed Original ResearchConceptsGroup-transfer pathwaysReaction activityDissociation rate constantsElectron transfer chainAcceptor couplesEnzyme-enzyme interactionsEnzyme concentrationRate constantsEnzyme-enzyme complexEnzyme interactionsComplexesControl of enzymesEnzyme complexEnzymeConcentrationBacterial phosphoenolpyruvateMain pathwayInteractionConstantsChainControl analysisSimple metabolic pathwaysSugar phosphotransferase system