2004
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
Markevich N, Hoek J, Kholodenko B. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. Journal Of Cell Biology 2004, 164: 353-359. PMID: 14744999, PMCID: PMC2172246, DOI: 10.1083/jcb.200308060.Peer-Reviewed Original ResearchConceptsExtracellular signal-regulated kinaseMultisite phosphorylationProtein kinase cascadeBistable switchSignal-regulated kinaseKinase cascadeMAPK cascadeWidespread mechanismDifferent kinasesSame phosphataseProtein kinasePositive feedback loopProtein activityDephosphorylation reactionsCovalent modificationKinaseMAPK phosphorylationFeedback regulationPhosphorylationKinetic propertiesPhosphataseFeedback loopCascade
1995
DYNAMIC ASPECTS OF CASCADE-TYPE METABOLIC REGULATION
MOLENAAR D, KHOLODENKO B, VAN HEESWIJK W, WESTERHOFF H. DYNAMIC ASPECTS OF CASCADE-TYPE METABOLIC REGULATION. Journal Of Biological System 1995, 3: 187-196. DOI: 10.1142/s0218339095000186.Peer-Reviewed Original Research