2016
NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo
Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE. NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. Journal Of Experimental Medicine 2016, 213: 657-665. PMID: 27045008, PMCID: PMC4854734, DOI: 10.1084/jem.20151809.Peer-Reviewed Original ResearchConceptsSpecific bacterial proteinsNAIP proteinsNeedle proteinBacterial proteinsGenetic evidenceSpecific bacterial ligandsBacterial ligandsBacterial type III secretion systemInner rod proteinType III secretion systemT3SS needle proteinStrong biochemical evidenceCytosolic flagellinFlagellin detectionRod proteinsSecretion systemDetection of flagellinCRISPR/Diverse functionsCytosolic detectionNAIP1ProteinBiochemical evidenceNAIPsFlagellin
2001
Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair
Geiser T, Kazmierczak B, Garrity‐Ryan L, Matthay M, Engel J. Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair. Cellular Microbiology 2001, 3: 223-236. PMID: 11298646, DOI: 10.1046/j.1462-5822.2001.00107.x.Peer-Reviewed Original ResearchConceptsGTPase-activating proteinsEpithelial wound repairPseudomonas aeruginosa ExoTRho family GTPasesWound repairPathogen Pseudomonas aeruginosaNosocomial pathogen Pseudomonas aeruginosaP. aeruginosa internalizationEpithelial cellsP. aeruginosaGAP domainGAP activityBacterial proteinsCell roundingCytoskeleton collapseLung epithelial wound repairExoTCell detachmentVivo virulenceProteinEpithelial tissue damageImmune effector cellsLocal host defenseIntact epithelial barrierHost defense