2014
The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
Jensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersCocaine-induced paranoiaAnxiety disorder casesWhole blood cellsPsychiatric disorder riskWarrants further investigationAfrican American subjectsComorbid drugPD casesPsychiatric disordersAlcohol dependenceBrain tissueCocaine useBehavioral effectsBlood cellsClinical potentialGene variantsDisordersDisorder casesSingle nucleotide polymorphismsDisorder riskIndependent samplesPsychiatric phenotypesFurther investigation
2011
Corticotrophin-Releasing Hormone Type 1 Receptor Gene ( CRHR1 ) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients
Amstadter A, Nugent N, Yang B, Miller A, Siburian R, Moorjani P, Haddad S, Basu A, Fagerness J, Saxe G, Smoller J, Koenen K. Corticotrophin-Releasing Hormone Type 1 Receptor Gene ( CRHR1 ) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients. Disease Markers 2011, 30: 89-99. DOI: 10.1155/2011/928497.Peer-Reviewed Original ResearchPosttraumatic stress disorderPediatric injury patientsTraumatic event exposureInjury patientsSingle nucleotide polymorphismsPosttraumatic stress disorder onsetAcute PTSD symptomsEvent exposureTrajectory of symptomsReceptor gene variantsLongitudinal latent growth curve analysesAcute symptomsProspective studyPresent studySpecific molecular variantsDisorder onsetAcute aftermathFuture replication studiesPosttraumatic stress symptomsTraumatic life eventsSymptomsStress disorderAnxiety disordersPTSD symptomsSymptom levels