2024
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, Chesnut M, Holt-Gosselin B, Chang S, Stetz P, Ramirez C, Hack L, Korgaonkar M, Wintermark M, Gotlib I, Ma J, Williams L. Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety. Nature Medicine 2024, 30: 2076-2087. PMID: 38886626, PMCID: PMC11271415, DOI: 10.1038/s41591-024-03057-9.Peer-Reviewed Original ResearchBehavioral therapyFunctional magnetic resonance imaging protocolTask-free functional connectivityHeterogeneity of depressionBrain circuit dysfunctionResponse to pharmacotherapyTheoretical taxonomyAttentional circuitsNeurobiological dysfunctionBehavioral performanceCircuit dysfunctionCognitive tasksSubcortical regionsFunctional connectivityTask-freeAnxietyDepressionTheory-drivenPharmacotherapyStratification of patientsMagnetic resonance imaging protocolScoresPsychiatryDysfunctionClinical careFamilial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal study
2022
Lack of Robust Associations Between Prepandemic Coping Strategies and Frontolimbic Circuitry With Depression and Anxiety Symptoms During the COVID-19 Pandemic: A Preregistered Longitudinal Study
Holt-Gosselin B, Cohodes E, McCauley S, Foster J, Odriozola P, Zacharek S, Kribakaran S, Haberman J, Hodges H, Gee D. Lack of Robust Associations Between Prepandemic Coping Strategies and Frontolimbic Circuitry With Depression and Anxiety Symptoms During the COVID-19 Pandemic: A Preregistered Longitudinal Study. Behavioral Neuroscience 2022, 136: 528-540. PMID: 36395014, PMCID: PMC9884515, DOI: 10.1037/bne0000534.Peer-Reviewed Original ResearchConceptsFrontolimbic circuitryAnxiety symptomsFunctional connectivityMental health outcomesCoping strategiesResting-state functional magnetic resonanceAdaptive coping strategiesLongitudinal studyFunctional magnetic resonanceMental health problemsACC functional connectivityAdaptive copingPreregistered hypothesesInternalizing symptomsNeurobehavioral factorsEmotional responsesPreregistered studyNeurobiological factorsOngoing stressorsElevated symptomsDepression symptomsHealth outcomesCopingCOVID-19 pandemicRobust associationAssociations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral Mediators
Foster JC, Cohodes EM, Brieant AE, McCauley S, Odriozola P, Zacharek SJ, Pierre JC, Hodges HR, Kribakaran S, Haberman JT, Holt-Gosselin B, Gee DG. Associations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral Mediators. Biological Psychiatry Global Open Science 2022, 3: 362-373. PMID: 35959474, PMCID: PMC9356644, DOI: 10.1016/j.bpsgos.2022.07.006.Peer-Reviewed Original ResearchEarly life stressImpact of ELSResting-state functional connectivity dataEffects of ELSLife stress exposureCOVID-19 pandemicPandemic-related stressSignificant direct associationFunctional connectivity dataInternalizing symptomatologyELS exposurePsychiatric illnessOngoing COVID-19 pandemicGeneral populationSample of adultsPsychological functioningFunctional connectivityStress exposureMental healthSymptomatologyNeurobehavioral factorsAssociationEmotion regulationCOVIDDirect associationIntrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders
Fischer AS, Holt-Gosselin B, Hagan KE, Fleming SL, Nimarko AF, Gotlib IH, Singh MK. Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 855-866. PMID: 35272095, PMCID: PMC9452604, DOI: 10.1016/j.bpsc.2022.02.009.Peer-Reviewed Original ResearchConceptsLow-risk youthMood disordersFunctional connectivityFamilial riskFC differencesFC relativeRisk statusMajor depressive disorderHigh familial riskDepressive disorderMore effective interventionsBipolar disorderNovel interventionsIntrinsic connectivityEffective interventionsFrontal gyrusDisordersRiskGyrusPsychopathologyFamily rigidityNeural underpinningsInterventionNeural signaturesFamily dynamics
2021
Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2020
Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial
Fischer AS, Holt-Gosselin B, Fleming SL, Hack LM, Ball TM, Schatzberg AF, Williams LM. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology 2020, 46: 809-819. PMID: 33230268, PMCID: PMC8027440, DOI: 10.1038/s41386-020-00905-3.Peer-Reviewed Original ResearchConceptsMajor depressive disorderISPOT-D TrialReward neurocircuitryFunctional connectivitySymptom respondersQOL responsesAntidepressant medication responseFC relativeQuality of lifeSame time pointsNeural basisAntidepressant medicationVenlafaxine XRSymptom responseDepressive disorderHealthy controlsMedication responseSymptom alleviationADM treatmentADM responsesLife outcomesNeurocircuitrySymptomsTime pointsConnectivity profilesFunctional Connectivity of Reward Circuitry is a Core Mechanistic Biomarker of Treatment Response and Quality of Life in Depression
Holt-Gosselin B, Fischer A, Fleming S, Hack L, Ball T, Schatzberg A, Williams L. Functional Connectivity of Reward Circuitry is a Core Mechanistic Biomarker of Treatment Response and Quality of Life in Depression. Biological Psychiatry 2020, 87: s396-s397. DOI: 10.1016/j.biopsych.2020.02.1014.Peer-Reviewed Original Research