Prenatal Opioid and Alcohol Exposures: Association with Altered Placental Serotonin Transporter Structure and/or Expression
Darbinian N, Merabova N, Tatevosian G, Adele S, Darbinyan A, Morrison M, DeVane C, Ramamoorthy S, Goetzl L, Selzer M. Prenatal Opioid and Alcohol Exposures: Association with Altered Placental Serotonin Transporter Structure and/or Expression. International Journal Of Molecular Sciences 2024, 25: 11570. PMID: 39519122, PMCID: PMC11546934, DOI: 10.3390/ijms252111570.Peer-Reviewed Original ResearchSERT expressionGestational age-matched controlsBrain serotonergic neurotransmissionElective pregnancy terminationTrimester human placentaPlacental membrane vesiclesDrugs of abuseAge-matched controlsOpioid-exposedPrenatal opioidsOpioid groupSERT levelsSerotonergic neurotransmissionFetal exposureMaternal placentaPregnancy terminationPregnant womenAlcohol exposureNeurodevelopmental implicationsQuantitative Western blottingHuman placentaOpioidNeurodevelopmental problemsPrenatal substance exposurePlacentaFetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs)
Darbinian N, Hampe M, Martirosyan D, Bajwa A, Darbinyan A, Merabova N, Tatevosian G, Goetzl L, Amini S, Selzer M. Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs). International Journal Of Molecular Sciences 2024, 25: 5826. PMID: 38892014, PMCID: PMC11172088, DOI: 10.3390/ijms25115826.Peer-Reviewed Original ResearchFetal alcohol spectrum disordersEffects of EtOH exposureAt-risk fetusesNon-drinking controlsFetal brain tissueVoluntary pregnancy terminationGestational ageFetal sexEtOH exposureMaternal bloodMother's serumEtOH-exposedPregnancy terminationFetal brainDrank alcoholMatched controlsPotential diagnostic biomarkersBrain-derived exosomesSonic hedgehogNeurodevelopmental disabilitiesDiagnostic biomarkersProtein levelsNeurodevelopmental disordersSpectrum disorderBrain tissue