2017
Cerebrospinal fluid circulating tumor cells: a novel tool to diagnose leptomeningeal metastases from epithelial tumors
Lin X, Fleisher M, Rosenblum M, Lin O, Boire A, Briggs S, Bensman Y, Hurtado B, Shagabayeva L, DeAngelis LM, Panageas KS, Omuro A, Pentsova EI. Cerebrospinal fluid circulating tumor cells: a novel tool to diagnose leptomeningeal metastases from epithelial tumors. Neuro-Oncology 2017, 19: 1248-1254. PMID: 28821205, PMCID: PMC5570249, DOI: 10.1093/neuonc/nox066.Peer-Reviewed Original ResearchConceptsDiagnosis of LMLeptomeningeal metastasesCSF CTCsCSF cytologyEpithelial tumorsMRI findingsOptimal cutoffInstitutional review board-approved prospective studyTumor cellsNegative predictive value 97ROC analysisRare cell capture technologyPositive predictive value 90Positive CSF cytologyCSF of patientsSolid tumor patientsPrevious pilot studyClinical suspicionProspective studyCytology examinationTumor patientsLarge cohortCerebrospinal fluidPatientsStandard MRI
2008
Brain tumors and dementia
Omuro AM, Delattre J. Brain tumors and dementia. Handbook Of Clinical Neurology 2008, 89: 877-886. PMID: 18631803, DOI: 10.1016/s0072-9752(07)01277-8.Peer-Reviewed Original ResearchConceptsCognitive dysfunctionBrain tumorsAdult brain tumor patientsMinor cognitive dysfunctionBrain tumor patientsQuality of lifeDiffuse cognitive dysfunctionSuch patientsTumor patientsPatient's lifeCognitive impairmentPatientsCognitive endpointsCognitive functionDysfunctionCommon typeDementiaTumorsDeleterious impactMildDiagnosisImpairmentTrialsEndpoint