2012
Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity
Gourley SL, Olevska A, Warren MS, Taylor JR, Koleske AJ. Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity. Journal Of Neuroscience 2012, 32: 2314-2323. PMID: 22396406, PMCID: PMC3386297, DOI: 10.1523/jneurosci.2730-11.2012.Peer-Reviewed Original ResearchConceptsSpine densityAdolescent wild-type mouseHippocampal CA1 pyramidal neuronsDendritic spine densityCA1 pyramidal neuronsPostnatal day 60Wild-type miceDendritic spine developmentCocaine-Induced PlasticityAddictive-like behaviorsPyramidal neuronsCocaine sensitizationDendritic spinesPsychomotor sensitizationProtective consequencesSpine headsNeuropsychiatric disordersOrbitofrontal cortexDay 60Local applicationArg inhibitionPsychomotor sensitivityIntracellular mechanismsPsychostimulant sensitivitySpine development
2007
Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior
Sfakianos MK, Eisman A, Gourley SL, Bradley WD, Scheetz AJ, Settleman J, Taylor JR, Greer CA, Williamson A, Koleske AJ. Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior. Journal Of Neuroscience 2007, 27: 10982-10992. PMID: 17928439, PMCID: PMC6672862, DOI: 10.1523/jneurosci.0793-07.2007.Peer-Reviewed Original ResearchConceptsDendritic spine maturationDendritic regressionSpine maturationDendritic spinesNormal morphological maturationDendritic spine lossPostnatal day 21Late postnatal developmentPostnatal mouse hippocampusDendrite stabilityPyramidal dendritesSpine lossSynaptic refinementProgressive deficitsHippocampal synapsesMature neuronsArbor developmentInhibitory pathwaysMouse hippocampusDendrite arborsDay 21Postnatal developmentMorphological maturationDendritic branchesDendrite morphogenesis