2017
Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase
Shapiro LP, Omar MH, Koleske AJ, Gourley SL. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Molecular And Cellular Neuroscience 2017, 85: 226-234. PMID: 29107098, PMCID: PMC5767942, DOI: 10.1016/j.mcn.2017.10.007.Peer-Reviewed Original ResearchConceptsCorticosterone exposureHippocampal CA1 pyramidal neuronsStressor exposureArbor structureCA1 pyramidal neuronsAnhedonic-like behaviorClassical neurotransmitter systemsSpecific brain regionsMental health concernsDendrite lossPyramidal neuronsStress-related illnessesArg nonreceptor tyrosine kinaseNeuronal remodelingNeurotransmitter systemsNeural degenerationBehavioral abnormalitiesTrigger pointsCognitive declineBrain regionsKey next stepHealth concernKey mediatorMental healthPharmacological compounds
2013
Arg kinase signaling in dendrite and synapse stabilization pathways: Memory, cocaine sensitivity, and stress
Kerrisk ME, Koleske AJ. Arg kinase signaling in dendrite and synapse stabilization pathways: Memory, cocaine sensitivity, and stress. The International Journal Of Biochemistry & Cell Biology 2013, 45: 2496-2500. PMID: 23916785, PMCID: PMC3797846, DOI: 10.1016/j.biocel.2013.07.018.Peer-Reviewed Original ResearchConceptsNeuronal actin cytoskeletonPhosphorylation of substratesNonreceptor tyrosine kinaseArg nonreceptor tyrosine kinaseActin cytoskeletonPostnatal mouse brainDendritic spinesArg kinaseMolecular mechanismsF-actinTyrosine kinaseSignaling pathwaysPostnatal day 21Synapse stabilityIntegrin α3β1KinaseNeurodegenerative diseasesNeuronal remodelingTherapeutic approachesCocaine sensitivityStabilization pathwayDay 21Arbor sizeMouse brainArg