2010
Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration
Couch BA, DeMarco GJ, Gourley SL, Koleske AJ. Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration. Journal Of Alzheimer's Disease 2010, 20: 1003-1008. PMID: 20413901, PMCID: PMC3077946, DOI: 10.3233/jad-2010-091114.Peer-Reviewed Original ResearchConceptsDendrite arborsPS1 miceAβPP/PS1 miceAmyloid-beta overproductionPS1 transgenic miceCA1 pyramidal neuronsROCK inhibitor fasudilROCK signalingPyramidal neuronsDendritic regressionFasudil administrationPharmacological reductionInhibitor fasudilTransgenic miceAlzheimer's diseaseMiceDendrite branchingRho-kinaseArborsDiseaseNeuronsSignalingAtrophyFasudilAbeta
2008
T cell survival and function requires the c-Abl tyrosine kinase
Silberman I, Sionov RV, Zuckerman V, Haupt S, Goldberg Z, Strasser A, Ben-Sasson ZS, Baniyash M, Koleske AJ, Haupt Y. T cell survival and function requires the c-Abl tyrosine kinase. Cell Cycle 2008, 7: 3847-3857. PMID: 19098427, PMCID: PMC3407662, DOI: 10.4161/cc.7.24.7267.Peer-Reviewed Original ResearchConceptsT cellsThymic atrophyT cell numbersAnti-tumor antibodiesAdult T-cellT cell functionT cell survivalDeficient T cellsTumor cell killingLck-Cre transgeneSyngeneic tumorsCell-autonomous roleEarly deathImmune systemIncreased susceptibilityMiceImpaired abilityCell functionAtrophyCell killingCell numberSurvivalOxidative stress stimuliCell survivalRole of Abl