2007
Molecular mechanisms controling vessel branching and morphogenesis
Eichmann A. Molecular mechanisms controling vessel branching and morphogenesis. The FASEB Journal 2007, 21: a197-a197. DOI: 10.1096/fasebj.21.5.a197-b.Peer-Reviewed Original ResearchMatrix-bound vascular endothelial growth factorVertebrate vascular systemAxon guidance cue netrin-1Endothelial tip cellsVessel branchingAxonal growth conesVessel morphogenesisGuidance cue netrin-1Tip cellsSpecialized endothelial cellsEndothelial cellsNegative regulatorMolecular mechanismsPathological angiogenesisGrowth conesUNC5B receptorMorphogenesisDelta-like4Growth factorBranched networkVascular endothelial growth factorNetrin-1Vascular systemEndothelial growth factorCells
2005
Control of arterial branching morphogenesis in embryogenesis: go with the flow
le Noble F, Fleury V, Pries A, Corvol P, Eichmann A, Reneman R. Control of arterial branching morphogenesis in embryogenesis: go with the flow. Cardiovascular Research 2005, 65: 619-628. PMID: 15664388, DOI: 10.1016/j.cardiores.2004.09.018.Peer-Reviewed Original ResearchConceptsBranching morphogenesisArterial-venous differentiationPatterning mechanismsMorphological eventsEmbryogenesisMorphogenesisEmbryonic arteriesEmbryo survivalPivotal roleEndothelial cellsVascular systemVivo observationsRemodeling processPre-existing collateralsProminent roleEmbryo-fetal developmentDifferentiationRegulationRoleIschemic diseasesPlasticityArterial growthDisconnection processNew strategyTrees
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance function