2014
Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model
Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nature Communications 2014, 5: 4563. PMID: 25081057, PMCID: PMC4143949, DOI: 10.1038/ncomms5563.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnticonvulsantsDisease Models, AnimalElectroencephalographyEpilepsyGene Expression RegulationHeterozygoteHumansMaleMiceMice, TransgenicMicrotomyNeocortexPatch-Clamp TechniquesPyrazolesQuinolonesReceptors, N-Methyl-D-AspartateSignal TransductionTissue Culture TechniquesTOR Serine-Threonine KinasesTuberous SclerosisTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsConceptsN-methyl-D-aspartate receptorsTuberous sclerosis complexGluN2C expressionSpiny stellate cellsEarly postnatal lifeGluN2C/DPromising molecular targetBlock seizuresMTOR-dependent mannerSurgical resectionCortical tubersEarly epilepsyUnprovoked seizuresPharmacoresistant epilepsyTSC patientsSeizure generationBrain malformationsFunctional upregulationMurine modelStellate cellsPostnatal lifeRecurrent excitationTumor suppressor geneEpilepsySeizures
2001
Electrophysiological Characteristics of Reactive Astrocytes in Experimental Cortical Dysplasia
Bordey A, Lyons SA, Hablitz JJ, Sontheimer H. Electrophysiological Characteristics of Reactive Astrocytes in Experimental Cortical Dysplasia. Journal Of Neurophysiology 2001, 85: 1719-1731. PMID: 11287494, DOI: 10.1152/jn.2001.85.4.1719.Peer-Reviewed Original ResearchConceptsGap junction couplingReactive gliosisFreeze lesionGlial fibrillary acidic protein immunoreactivityWhole-cell patch-clamp recordingsCell patch-clamp recordingsExperimental cortical dysplasiaCortical layers IPatch-clamp recordingsPostnatal day 16Reduced gap junction couplingNormal neuronal functionDysplastic neocortexP24 ratsDysplastic cortexReactive astrocytesCortical dysplasiaNeuronal dysfunctionProtein immunoreactivityElectrophysiological characteristicsAstrocytesChannel expressionNeuronal functionMicrosulcusLayer I