2012
NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development
Young SZ, Taylor MM, Wu S, Ikeda-Matsuo Y, Kubera C, Bordey A. NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development. Journal Of Neuroscience 2012, 32: 13630-13638. PMID: 23015452, PMCID: PMC3478384, DOI: 10.1523/jneurosci.2864-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornCalciumCell CountCell DifferentiationCell ProliferationCells, CulturedCerebral VentriclesDendritesEgtazic AcidElectroporationFemaleGABA ModulatorsGABA-A Receptor AgonistsGreen Fluorescent ProteinsIn Vitro TechniquesKi-67 AntigenLuminescent ProteinsMaleMiceMuscimolNeural Stem CellsNeuronsOlfactory BulbPatch-Clamp TechniquesPentobarbitalReceptors, GABA-ARNA, Small InterferingSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2SOXB1 Transcription FactorsTransfectionConceptsNPC proliferationDecreased neuronal densityTotal dendritic lengthNeonatal subventricular zoneNeural stem cell proliferationNeural progenitor cell developmentNeural progenitor proliferationShort hairpin RNADendritic complexityDendritic lengthNeuronal densityNewborn neuronsDendritic arborizationNeuron densityDendritic developmentSubventricular zoneNeuron productionCalcium responseSynaptic integrationNKCC1 knockdownPentobarbital effectsAllosteric agonistDendritic treeProgenitor cell developmentCotransporter NKCC1
2011
Adult‐born neuron development is controlled by GABAA receptor subtypes (Commentary on Duveau et al.)
Bordey A. Adult‐born neuron development is controlled by GABAA receptor subtypes (Commentary on Duveau et al.). European Journal Of Neuroscience 2011, 34: 361-361. PMID: 21801241, DOI: 10.1111/j.1460-9568.2011.07807.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2009
GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation
Dave KA, Bordey A. GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation. IUBMB Life 2009, 61: 496-503. PMID: 19391160, PMCID: PMC2675662, DOI: 10.1002/iub.185.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidRole of GABAVertebrate central nervous systemComplement of receptorsCerebellar granule cell precursorsCell precursorsGranule cell precursorsDevelopmental processesMetabotropic glutamate receptorsCentral nervous systemCell proliferationAdult mammalsNovel targetAmino acid glutamatePharmacological regulationCurrent knowledgeGlutamate receptorsNeural cancersNervous systemCerebellar tumorsCalcium increaseReceptorsProliferationMammalsNovel data
2008
GABAA receptors, anesthetics and anticonvulsants in brain development.
Henschel O, Gipson KE, Bordey A. GABAA receptors, anesthetics and anticonvulsants in brain development. CNS & Neurological Disorders - Drug Targets 2008, 7: 211-24. PMID: 18537647, PMCID: PMC2557552, DOI: 10.2174/187152708784083812.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGABAergic drugsBrain developmentLong-term cognitive deficitsMain inhibitory neurotransmitterFunction of GABANeonatal periodInhibitory neurotransmitterGABAA receptorsMature brainNeuronal excitabilitySide effectsCognitive deficitsClinical perspectiveGABACNS developmentReceptorsReceptor propertiesDrugsAnticonvulsantsAnestheticsBasic scienceReviewSedativesExcitabilityNeurotransmitters
2004
GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone
Bolteus AJ, Bordey A. GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone. Journal Of Neuroscience 2004, 24: 7623-7631. PMID: 15342728, PMCID: PMC6729616, DOI: 10.1523/jneurosci.1999-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBicucullineBiological TransportBrainCalcium SignalingCell MovementGABA Plasma Membrane Transport ProteinsGABA-A Receptor AgonistsGamma-Aminobutyric AcidMass SpectrometryMembrane Transport ProteinsMiceMicroscopy, VideoNeuronsPatch-Clamp TechniquesPotassiumReceptors, GABA-AStem CellsConceptsAstrocyte-like cellsSubventricular zoneNeuronal precursorsPostnatal subventricular zoneNeuronal precursor migrationCell migrationPrecursor migrationPresence of bicucullineEnhancement of GABAAnterior subventricular zoneInhibition of GABARostral migratory streamAmbient GABA levelsApplication of GABASagittal brain slicesAntagonist bicucullineGABA releaseEndogenous GABAGABA levelsBrain slicesAdult miceGABA transporterMigratory streamGABACell depolarization
2003
GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation
Wang DD, Krueger DD, Bordey A. GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation. The Journal Of Physiology 2003, 550: 785-800. PMID: 12807990, PMCID: PMC2343064, DOI: 10.1113/jphysiol.2003.042572.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBarbituratesBenzodiazepinesCerebral VentriclesDose-Response Relationship, DrugElectrophysiologyGABA AntagonistsGamma-Aminobutyric AcidGlutamate DecarboxylaseIsoenzymesMembrane PotentialsMiceNeostriatumNeuronsPatch-Clamp TechniquesPicrotoxinPotassium ChannelsReceptors, GABA-AStem CellsZincConceptsRostral migratory streamGABAA receptor activationSubventricular zoneNeuronal progenitorsReceptor activationGlutamic acid decarboxylase 67Resting potentialsPostnatal mammalian brainPatch-clamp recordingsSVZ/RMSMouse brain slicesRecorded cellsCell-attached patchesGABA responsesBrain slicesNeurotransmitter GABASubset of progenitorsBenzodiazepine agonistsEmbryonic neuronsAction potentialsMammalian brainMigratory streamGABAInverse agonistSpecific receptors
2002
GAT-1 and Reversible GABA Transport in Bergmann Glia in Slices
Barakat L, Bordey A. GAT-1 and Reversible GABA Transport in Bergmann Glia in Slices. Journal Of Neurophysiology 2002, 88: 1407-1419. PMID: 12205162, DOI: 10.1152/jn.2002.88.3.1407.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCarrier ProteinsCerebellumElectrophysiologyGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidIn Vitro TechniquesMembrane ProteinsMembrane Transport ProteinsNeurogliaOrganic Anion TransportersPatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptors, GABA-AConceptsGAT-1Bergmann gliaInward currentsGABA transporterWhole-cell patch-clamp recordingsCell patch-clamp recordingsGlial GABA uptakePatch-clamp recordingsRat cerebellar slicesGABA perfusionReceptor blockersAmbient GABANNC-711Extracellular GABAGABA effluxGABA uptakeGABA receptorsCerebellar slicesGAT subtypesNipecotic acidReceptor activationGABABlockersGliaOutward currentsCarrier‐mediated uptake and release of taurine from Bergmann glia in rat cerebellar slices
Barakat L, Wang D, Bordey A. Carrier‐mediated uptake and release of taurine from Bergmann glia in rat cerebellar slices. The Journal Of Physiology 2002, 541: 753-767. PMID: 12068038, PMCID: PMC2290349, DOI: 10.1113/jphysiol.2001.015834.Peer-Reviewed Original ResearchConceptsRat cerebellar slicesBergmann gliaGuanidinoethyl sulphonateCerebellar slicesTaurine transporterInward currentsWhole-cell patch-clamp recordingsTaurine uptakeGABA receptor blockersTaurine transporter inhibitorRelease of taurinePatch-clamp recordingsDependent taurine transporterOrder of potencyTaurine perfusionReceptor blockersIntracellular taurineIschemic conditionsCarrier-mediated uptakeTaurine effluxOutward currentsTransporter currentsTransporter inhibitorsIntracellular perfusionGlia