2004
Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
Huang H, Bordey A. Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons. Journal Of Neuroscience 2004, 24: 5659-5669. PMID: 15215288, PMCID: PMC6729224, DOI: 10.1523/jneurosci.1338-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid Transport System X-AGAnimalsAntiportersCalciumCerebellumCystineEvoked PotentialsGamma-Aminobutyric AcidGlutamic AcidIn Vitro TechniquesMiceNerve FibersNeural InhibitionNeurogliaPatch-Clamp TechniquesPurkinje CellsReceptors, N-Methyl-D-AspartateReceptors, PresynapticRyanodineSynaptic TransmissionConceptsGlial glutamate transportersMiniature IPSCsPurkinje neuronsGlutamate transportersSpontaneous IPSCsSynaptic inhibitionInhibitory synapsesNMDAR activationWhole-cell patch-clamp recordingsPresynaptic NMDA receptorsPaired-pulse ratioMouse cerebellar slicesNMDA receptor activationPresynaptic NMDA receptor activationPatch-clamp recordingsBergmann glial cellsBeta-benzyloxyaspartic acidAdjacent Purkinje neuronsCystine-glutamate antiporterMIPSC frequencyGABAergic terminalsGABAergic synapsesGlial cellsNMDA receptorsExcitatory synapses
2003
Modulation of Glutamatergic Transmission by Bergmann Glial Cells in Rat Cerebellum In Situ
Bordey A, Sontheimer H. Modulation of Glutamatergic Transmission by Bergmann Glial Cells in Rat Cerebellum In Situ. Journal Of Neurophysiology 2003, 89: 979-988. PMID: 12574474, DOI: 10.1152/jn.00904.2002.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAmino Acid Transport System X-AGAnimalsAspartic AcidCell CommunicationElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGlutamic AcidMembrane PotentialsNerve FibersNeurogliaN-MethylaspartatePatch-Clamp TechniquesPurkinje CellsRatsRats, Sprague-DawleyReceptors, GlutamateSodiumSynaptic TransmissionConceptsExcitatory postsynaptic currentsBergmann glial cellsGlial cellsPurkinje cell synapseInward currentsCell synapseGlu transportPurkinje cellsSpontaneous excitatory postsynaptic currentsAbsence of TTXPresynaptic glutamate releaseCerebellar brain slicesSpontaneous EPSC frequencyPatch-clamp recordingsSingle glial cellsIonotropic Glu receptorsParallel fibersEPSC frequencyPresynaptic effectsExcitatory transmissionGlutamate releaseGlutamatergic transmissionPostsynaptic currentsGlu receptorsBrain slices
2000
Ion channel expression by astrocytes in situ: Comparison of different CNS regions
Bordey A, Sontheimer H. Ion channel expression by astrocytes in situ: Comparison of different CNS regions. Glia 2000, 30: 27-38. PMID: 10696142, DOI: 10.1002/(sici)1098-1136(200003)30:1<27::aid-glia4>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsBergmann glial cellsIon channel complementGlial cellsIon channel expressionDifferent CNS regionsCNS regionsChannel expressionPercentage of astrocytesTransient A-typeCerebellar Bergmann glial cellsChannel complementPatch-clamp recordingsVoltage-activated currentsPostnatal day 17Whole-cell currentsIon channelsVoltage-gated ion channelsBrain slicesRat astrocytesAstrocytesDay 17Low input resistanceInput resistanceCNSInitial recording