2021
Circulating CD4+ TEMRA and CD4+ CD28− T cells and incident diabetes among persons with and without HIV
Bailin SS, Kundu S, Wellons M, Freiberg MS, Doyle MF, Tracy RP, Justice AC, Wanjalla CN, Landay AL, So-Armah K, Mallal S, Kropski JA, Koethe JR. Circulating CD4+ TEMRA and CD4+ CD28− T cells and incident diabetes among persons with and without HIV. AIDS 2021, 36: 501-511. PMID: 34860194, PMCID: PMC8881388, DOI: 10.1097/qad.0000000000003137.Peer-Reviewed Original ResearchConceptsT cell subsetsIncident diabetesT cellsVeterans Aging Cohort StudyPeripheral mononuclear blood cellsIncident diabetes diagnosisPrevalent diabetes mellitusT effector memoryHIV-negative personsHIV-negative individualsTraditional risk factorsAging Cohort StudyCD28- T cellsSenescent T cellsT cell populationsProportional hazards modelMononuclear blood cellsHigh baseline frequencyCytomegalovirus serostatusCirculating CD4Chart reviewCohort studyEffector memoryInflammatory biomarkersMemory CD4Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies
Davis K, Perez-Guzman P, Hoyer A, Brinks R, Gregg E, Althoff KN, Justice AC, Reiss P, Gregson S, Smit M. Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies. BMC Medicine 2021, 19: 105. PMID: 33980222, PMCID: PMC8117497, DOI: 10.1186/s12916-021-01978-7.Peer-Reviewed Original ResearchConceptsHIV-negative individualsCross-sectional studyHIV statusHypertension riskPrevalent hypertensionRisk ratioObservational studyGlobal systematic reviewSystematic reviewEffective antiretroviral therapyHIV-negative controlsNon-communicable diseasesStudy-level factorsDifferent risk factorsRandom-effects modelHypertension differsAntiretroviral therapyHypertension preventionHIV infectionCochrane CENTRALRisk factorsHypertensionPLHIVMAIN OUTCOMEHigh riskExcess burden of age-associated comorbidities among people living with HIV in British Columbia, Canada: a population-based cohort study
Nanditha NGA, Paiero A, Tafessu HM, St-Jean M, McLinden T, Justice AC, Kopec J, Montaner JSG, Hogg RS, Lima VD. Excess burden of age-associated comorbidities among people living with HIV in British Columbia, Canada: a population-based cohort study. BMJ Open 2021, 11: e041734. PMID: 33419911, PMCID: PMC7799128, DOI: 10.1136/bmjopen-2020-041734.Peer-Reviewed Original ResearchConceptsHIV-negative controlsAge-associated comorbiditiesPopulation-based cohort studyCohort studyPrevalence trendsDiagnosis of comorbiditiesHIV-negative counterpartsNon-AIDS comorbiditiesHIV-negative individualsProvincial administrative databasesHIV care modelAdministrative health dataAge-associated conditionsLongitudinal cohort dataEarly ageAIDS comorbiditiesLiver diseaseEligible participantsLung diseaseAdministrative databasesHigh prevalencePLWHComorbiditiesCare modelKruskal-Wallis test
2020
T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus
Bailin SS, McGinnis KA, McDonnell WJ, So-Armah K, Wellons M, Tracy RP, Doyle MF, Mallal S, Justice AC, Freiberg MS, Landay AL, Wanjalla C, Koethe JR. T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2020, 222: 252-262. PMID: 32052044, PMCID: PMC7323499, DOI: 10.1093/infdis/jiaa069.Peer-Reviewed Original ResearchConceptsT cell subsetsT cellsMemory CD4Prevalent diabetesMemory T cell expansionVeterans Aging Cohort StudyMultivariable logistic regression modelHuman immunodeficiency virus (HIV) populationPrevalent diabetes casesPrevalent diabetes mellitusChronic immune activationHIV-negative individualsHIV-negative participantsT lymphocyte subsetsPrevalence of diabetesTraditional risk factorsAging Cohort StudyHuman immunodeficiency virusT cell expansionLogistic regression modelsCytomegalovirus serostatusLymphocyte subsetsCohort studyDiabetes mellitusHIV status
2018
Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study)
Marconi VC, Duncan MS, So‐Armah K, Re VL, Lim JK, Butt AA, Goetz MB, Rodriguez‐Barradas M, Alcorn CW, Lennox J, Beckman JA, Justice A, Freiberg M. Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study). Journal Of The American Heart Association 2018, 7: e007792. PMID: 29720501, PMCID: PMC6015337, DOI: 10.1161/jaha.117.007792.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal cardiovascular diseaseIschemic stroke eventsCardiovascular diseaseCVD eventsHeart failureMyocardial infarctionTotal bilirubinElevated bilirubinStroke eventsRisk factorsIncident total CVDBaseline total bilirubinBaseline cardiovascular diseaseIncident CVD eventsHIV-negative individualsProspective cohort studyElevated bilirubin levelsMultiple risk factorsCohort studyCVD riskHazard ratioIschemic strokeHIV-positiveBilirubin levels
2017
Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans
Nelson KN, Hui Q, Rimland D, Xu K, Freiberg MS, Justice AC, Marconi VC, Sun YV. Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans. AIDS 2017, 31: 571-575. PMID: 27922854, PMCID: PMC5263111, DOI: 10.1097/qad.0000000000001360.Peer-Reviewed Original ResearchConceptsHIV-positive individualsHIV-negative individualsHIV infectionART initiationBlood samplesTreatment-naive HIV-positive individualsVeterans Aging Cohort StudyHIV-negative groupHIV-positive patientsAging Cohort StudyDNAm ageCohort of veteransPeripheral blood samplesNaive HIVAntiretroviral therapyAntiretroviral treatmentCohort studyStudy cohortAge-related diseasesMyocardial infarctionLarge cohortHealthy personsHigh riskHIVU.S. veterans
2008
An experimental study of the agreement of self-administration and telephone administration of the Timeline Followback interview.
Maisto SA, Conigliaro JC, Gordon AJ, McGinnis KA, Justice AC. An experimental study of the agreement of self-administration and telephone administration of the Timeline Followback interview. Journal Of Studies On Alcohol And Drugs 2008, 69: 468-71. PMID: 18432391, PMCID: PMC3115624, DOI: 10.15288/jsad.2008.69.468.Peer-Reviewed Original ResearchConceptsDaily alcohol consumptionAlcohol consumptionTimeline Followback interviewObservational studyVeterans Aging Cohort StudyHIV-negative adultsHIV-negative individualsHIV-negative menAging Cohort StudyGeneral medicine clinicLarge observational studiesMedian total numberExcellent test-retest reliabilityMultisite observational studyCohort studyTest-retest reliabilityMedicine clinicOngoing longitudinal studyHIVInfectious diseasesTelephone interviewsTelephone administrationClassification of participantsAdministrationSame findings
2004
Association of hypocholesterolaemia with hepatitis C virus infection in HIV‐infected people*
Polgreen P, Fultz S, Justice A, Wagner J, Diekema D, Rabeneck L, Weissman S, Stapleton J. Association of hypocholesterolaemia with hepatitis C virus infection in HIV‐infected people*. HIV Medicine 2004, 5: 144-150. PMID: 15139979, DOI: 10.1111/j.1468-1293.2004.00202.x.Peer-Reviewed Original ResearchConceptsHCV antibody statusHIV exposure categoryTotal cholesterol levelsCholesterol levelsHCV antibodiesHCV infectionAntibody statusExposure categoriesDrug useHepatitis C virus statusHigh-density lipid cholesterolLipid-lowering drug useLow-density lipid cholesterolHepatitis C virus infectionLiver function test resultsLower total cholesterol levelsLipid cholesterolC virus statusHCV-negative subjectsC virus infectionHCV-positive patientsHIV-positive patientsProtease inhibitor useHIV viral loadHIV-negative individuals