2020
Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index
King JT, Yoon JS, Rentsch CT, Tate JP, Park LS, Kidwai-Khan F, Skanderson M, Hauser RG, Jacobson DA, Erdos J, Cho K, Ramoni R, Gagnon DR, Justice AC. Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index. PLOS ONE 2020, 15: e0241825. PMID: 33175863, PMCID: PMC7657526, DOI: 10.1371/journal.pone.0241825.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexVeterans Health AdministrationVACO IndexValidation cohortMedical administrative dataDevelopment cohortSARS-CoV-2 testing resultsMortality indexICD-10 diagnosis codesUS Veterans Health AdministrationSARS-CoV-2 infectionPre-existing medical conditionsCOVID-19 mortality riskPeripheral vascular diseaseCOVID-19 patientsCOVID-19 infectionCOVID-19 mortalitySARS-CoV-2Administrative dataLogistic regression modelsRace/ethnicityCohort subgroupsComorbidity indexOverall mortalityComorbid conditionsPatterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study
Rentsch CT, Kidwai-Khan F, Tate JP, Park LS, King JT, Skanderson M, Hauser RG, Schultze A, Jarvis CI, Holodniy M, Re V, Akgün KM, Crothers K, Taddei TH, Freiberg MS, Justice AC. Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study. PLOS Medicine 2020, 17: e1003379. PMID: 32960880, PMCID: PMC7508372, DOI: 10.1371/journal.pmed.1003379.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBetacoronavirusBlack or African AmericanClinical Laboratory TechniquesCohort StudiesCoronavirus InfectionsCOVID-19COVID-19 TestingEthnicityFemaleHispanic or LatinoHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2United StatesVeteransWhite PeopleYoung AdultConceptsCOVID-19 testingRace/ethnicityCohort studyWhite individualsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionSyndrome coronavirus 2 infectionSARS-CoV-2 infectionCOVID-19Large integrated healthcare systemCoronavirus 2 infectionNationwide cohort studyRetrospective cohort studyCoronavirus disease 2019Site of careIntegrated healthcare systemNon-Hispanic blacksPositive test resultsNon-Hispanic whitesClinical characteristicsMultivariable adjustmentComorbid conditionsMedication historyEthnic minority communitiesDisease 2019
2019
Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research
Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz M, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack J, Yung R, Reeves RK. Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research. AIDS Research And Human Retroviruses 2019, 35: 999-1012. PMID: 31456412, PMCID: PMC6862961, DOI: 10.1089/aid.2019.0130.Peer-Reviewed Original Research
2016
The impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy
Edelman E, Gordon K, Tate J, Becker W, Bryant K, Crothers K, Gaither, Gibert C, Gordon A, Marshall B, Rodriguez‐Barradas M, Samet J, Skanderson M, Justice A, Fiellin D. The impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy. HIV Medicine 2016, 17: 728-739. PMID: 27186715, PMCID: PMC5053822, DOI: 10.1111/hiv.12377.Peer-Reviewed Original ResearchConceptsCD4 cell countBaseline CD4 cell countCell countPrescribed opioidsImmunosuppressive propertiesVeterans Aging Cohort Study (VACS) dataCD4 cell count recoveryAntiretroviral therapy responseCell count recoveryShort-term opioidsViral load suppressionCohort study dataOverall disease severityYear of initiationPrimary independent variableOpioid durationAntiretroviral therapyCount recoveryComorbid conditionsPharmacy dataOpioid propertiesTherapy responseOpioidsPatientsHIV
2012
HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation. Clinical Infectious Diseases 2012, 55: 126-136. PMID: 22534147, PMCID: PMC3493182, DOI: 10.1093/cid/cis406.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationVeterans Aging Cohort StudyAltered coagulationMonocyte activationUninfected veteransCardiovascular diseaseElevated biomarkersComorbid conditionsHigh prevalenceCD4 cell countElevated IL-6Aging Cohort StudyOngoing HIV replicationPrevalent cardiovascular diseaseHIV-1 RNAHuman immunodeficiency virusCopies/mLElevated sCD14More dyslipidemiaCD4 countHepatitis CCohort studyComorbid diseasesCurrent smokingHIV infection
2008
Depression Symptoms and Treatment Among HIV Infected and Uninfected Veterans
Sueoka K, Goulet JL, Fiellin DA, Rimland D, Butt AA, Gibert C, Rodriguez-Barradas MC, Bryant K, Crystal S, Justice AC. Depression Symptoms and Treatment Among HIV Infected and Uninfected Veterans. AIDS And Behavior 2008, 14: 272-279. PMID: 18648927, PMCID: PMC3125603, DOI: 10.1007/s10461-008-9428-7.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudySelective serotonin reuptake inhibitorsDepressive symptomsMental health providersDepression treatmentHealth providersPatient Health Questionnaire scoresActive depressive symptomsAging Cohort StudySerotonin reuptake inhibitorsCommon comorbid conditionsNon-Hispanic whitesHIV providersUninfected subjectsUninfected veteransCohort studyProspective cohortReuptake inhibitorsComorbid conditionsHIV statusPrimary careMental health counselingMultivariable modelQuestionnaire scoresDepression symptoms
2007
Do Patterns of Comorbidity Vary by HIV Status, Age, and HIV Severity?
Goulet JL, Fultz SL, Rimland D, Butt A, Gibert C, Rodriguez-Barradas M, Bryant K, Justice AC. Do Patterns of Comorbidity Vary by HIV Status, Age, and HIV Severity? Clinical Infectious Diseases 2007, 45: 1593-1601. PMID: 18190322, PMCID: PMC3687553, DOI: 10.1086/523577.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 cell countPatterns of comorbidityHIV infectionHIV statusCell countHIV severityOlder human immunodeficiency virusPrimary care guidelinesClinical Modification codesCells/Pulmonary diseaseComorbid conditionsMultivariable analysisViral loadCare guidelinesImmunodeficiency virusComorbiditiesInternational ClassificationMultimorbidityInfectionPresence of conditionsVeteransAgeDisease
2006
Association of Comorbidity with Physical Disability in Older HIV-Infected Adults
Oursler KK, Goulet JL, Leaf DA, Akingicil A, Katzel LI, Justice A, Crystal S. Association of Comorbidity with Physical Disability in Older HIV-Infected Adults. AIDS Patient Care And STDs 2006, 20: 782-791. PMID: 17134352, DOI: 10.1089/apc.2006.20.782.Peer-Reviewed Original ResearchConceptsHIV-negative patientsPhysical functioningComorbid conditionsVeterans Aging Cohort StudyGeneral medical comorbidityHIV medical careHIV-negative veteransRelationship of comorbiditiesHIV disease stageHIV-negative subjectsAssociation of comorbiditiesChronic lung diseaseAging Cohort StudyCoronary artery diseaseYears of ageSelf-reported difficultyOlder HIVAntiretroviral therapyMedical comorbiditiesCohort studyArtery diseaseClinical factorsPatient groupDisease stageLung diseaseRate and predictors of treatment prescription for hepatitis C
Butt AA, Justice AC, Skanderson M, Rigsby MO, Good CB, Kwoh CK. Rate and predictors of treatment prescription for hepatitis C. Gut 2006, 56: 385. PMID: 17005764, PMCID: PMC1856823, DOI: 10.1136/gut.2006.099150.Peer-Reviewed Original ResearchConceptsHepatitis C virusNational Patient Care DatabaseTreatment prescriptionPrescription ratesAlcohol abuseVeterans Affairs National Patient Care DatabaseDiagnosis of HCVPharmacy Benefits Management databaseMultivariate logistic regression modelHepatitis B infectionCoronary artery diseasePatient Care DatabasePsychiatric comorbid conditionsNon-white raceLogistic regression analysisPredictors of treatmentAlcohol use diagnosisLogistic regression modelsB infectionComorbid illnessesHepatitis CArtery diseaseLiver cirrhosisComorbid conditionsHispanic race
2005
Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans
Goulet JL, Fultz SL, McGinnis KA, Justice AC. Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AIDS 2005, 19: s99-s105. PMID: 16251836, DOI: 10.1097/01.aids.0000192077.11067.e5.Peer-Reviewed Original ResearchConceptsHIV/HCV-coHepatitis C virusAlcohol-related complicationsComorbid conditionsHCV-coTreatment optionsHIV monoChart extractionDiagnostic codesMental disordersCo-infected patientsElectronic medical record systemTreatment contraindicationsMedical record systemC virusHigh prevalenceMedical disordersHIVDemographic dataComorbiditiesLogistic regressionPrevalenceModerate agreementRelative prevalenceVeteransDifferences between Infectious Diseases—Certified Physicians and General Medicine—Certified Physicians in the Level of Comfort with Providing Primary Care to Patients
Fultz SL, Goulet JL, Weissman S, Rimland D, Leaf D, Gibert C, Rodriguez-Barradas MC, Justice AC. Differences between Infectious Diseases—Certified Physicians and General Medicine—Certified Physicians in the Level of Comfort with Providing Primary Care to Patients. Clinical Infectious Diseases 2005, 41: 738-743. PMID: 16080098, DOI: 10.1086/432621.Peer-Reviewed Original ResearchConceptsID clinicComorbid conditionsActive antiretroviral therapyInfectious disease clinicCommon comorbid conditionsHuman immunodeficiency virusGeneral medical clinicLevel of comfortAntiretroviral therapyComorbid diseasesDisease clinicSuch patientsSelf-reported comfortImmunodeficiency virusPrimary careHIV medicinePrescribing medicationsSubstantial prevalencePatientsPhysician levelClinicMedical clinicsGeneralist physiciansHypertensionHyperlipidemia
2001
Justification for a new cohort study of people aging with and without HIV infection
Justice AC, Landefeld CS, Asch SM, Gifford AL, Whalen CC, Covinsky KE. Justification for a new cohort study of people aging with and without HIV infection. Journal Of Clinical Epidemiology 2001, 54: s3-s8. PMID: 11750202, PMCID: PMC6563331, DOI: 10.1016/s0895-4356(01)00440-1.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyCohort studyChronic diseasesAging Cohort StudyLongitudinal cohort studyNew cohort studiesHIV/AIDSSubstance use/abuseUse/abuseNegative patientsHIV infectionOrgan injuryComorbid conditionsIatrogenic injuryDrug toxicityVeteran populationMethodologic issuesHIVDiseaseInjuryPopulationPatientsEtiologyInfectionStudy