2024
Multi-omic network analysis identifies dysregulated neurobiological pathways in opioid addiction
Sullivan K, Kainer D, Lane M, Cashman M, Miller J, Garvin M, Townsend A, Quach B, Willis C, Kruse P, Gaddis N, Mathur R, Corradin O, Maher B, Scacheri P, Sanchez-Roige S, Palmer A, Troiani V, Chesler E, Kember R, Kranzler H, Justice A, Xu K, Aouizerat B, Hancock D, Johnson E, Jacobson D, Program V. Multi-omic network analysis identifies dysregulated neurobiological pathways in opioid addiction. Biological Psychiatry 2024 PMID: 39615775, DOI: 10.1016/j.biopsych.2024.11.013.Peer-Reviewed Original ResearchGenome-wide association studiesSubstance use disordersOpioid use disorderAddiction treatmentOpioid addictionDorsolateral prefrontal cortexOpioid addiction treatmentMulti-omics network analysisPrefrontal cortexPrescription opioid misuseSystems biology approachNeurobiological pathwaysOpioid overdose victimsUse disorderOverdose victimsAddictionAssociation studiesEpigenetic dataOpioid misuseOpioidDlPFCERK pathwayBiology approachMulti-omicsGene targeting
2022
Antiviral Strategies Against SARS-CoV-2: A Systems Biology Approach
Prates ET, Garvin MR, Jones P, Miller JI, Sullivan KA, Cliff A, Gazolla JGFM, Shah MB, Walker AM, Lane M, Rentsch CT, Justice A, Pavicic M, Romero J, Jacobson D. Antiviral Strategies Against SARS-CoV-2: A Systems Biology Approach. Methods In Molecular Biology 2022, 2452: 317-351. PMID: 35554915, DOI: 10.1007/978-1-0716-2111-0_19.ChaptersConceptsSystems biology approachBiology approachHigh-performance computingArtificial intelligence methodologiesDiversity of informationIntelligence methodologiesStructural proteomicsSystem-level infrastructureMultiomics integrationCore frameworkViral pathogenesisAntiviral strategiesWealth of informationUnprecedented accessPathogensComputingComputational protocolPathogen detectionInformationProteomicsAdaptation analysisDevelopment of vaccinesProtocolInfrastructureNetwork