2024
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
de Laat B, Hoye J, Stanley G, Hespeler M, Ligi J, Mohan V, Wooten D, Zhang X, Nguyen T, Key J, Colonna G, Huang Y, Nabulsi N, Patel A, Matuskey D, Morris E, Tinaz S. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 34. PMID: 38336768, PMCID: PMC10858031, DOI: 10.1038/s41531-024-00641-1.Peer-Reviewed Original ResearchDopamine transporterSubstantia nigraDopaminergic neuronsDopamine transporter availabilityNeuroprotective effects of exerciseDopaminergic systemClinical progression of PDEarly PDSubstantiaNeuromelanin contentNigraLoss of dopaminergic neuronsEffects of exerciseNM-MRIDopamineSystem of patientsProgressive loss of dopaminergic neuronsParkinson's diseaseClinical progressionProgression of PDNeuroprotective effectsClinical trialsIntensity exercisePET imagingProgressive loss
2023
Differential impact of resilience on demoralization and depression in Parkinson disease
de Figueiredo J, Zhu B, Patel A, Kohn R, Koo B, Louis E. Differential impact of resilience on demoralization and depression in Parkinson disease. Frontiers In Psychiatry 2023, 14: 1207019. PMID: 37559912, PMCID: PMC10408307, DOI: 10.3389/fpsyt.2023.1207019.Peer-Reviewed Original Research
2022
Major Depressive Disorder in an International Multisite Wilson Disease Registry
Camarata M, Ala A, Coskun A, Deng Y, Embel V, Gonzalez-Peralta R, Maciejewski K, Patel A, Rubman S, To U, Tomlin R, Schilsky M, Zimbrean P. Major Depressive Disorder in an International Multisite Wilson Disease Registry. Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 106-117. PMID: 36521682, DOI: 10.1016/j.jaclp.2022.12.001.Peer-Reviewed Original ResearchConceptsMajor depressive disorderWilson's diseaseDepressive disorderLifetime major depressive disorderMental health QOLPhysical health QoLMajor depressive episodeMental health qualityStructured psychiatric evaluationSignificant differencesCross-sectional reportsLiver testsLiver diseaseNeurological assessmentLife scoresClinical correlatesDepressive episodePsychiatric symptomsPsychiatric evaluationDisease RegistrySevere anxietyLaboratory testsLifetime historySignificant associationPatientsMental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Cherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease. Brain Imaging And Behavior 2022, 17: 161-171. PMID: 36434490, PMCID: PMC10050121, DOI: 10.1007/s11682-022-00749-z.Peer-Reviewed Original ResearchConceptsImagery trainingFunctional connectivity changesMild Parkinson's diseaseVisual imagery trainingMental imagery trainingComplex cognitive processesConnectivity changesMotor imagery trainingBrain functional connectivity changesFunctional connectivity characteristicsExecutive processesMental imageryCognitive processesPerceptual experienceNeural correlatesBrain mechanismsImagery practiceImagery contentSensorimotor processesNeuropsychiatric patient populationsMotor functionMotor actsMotor enhancementBrain areasParkinson's disease
2020
P12 Effect of liver disease, neurological disease and mental health issues on quality of life in patients with wilson disease
Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Coskun A, Patel A, Wadhwa A, Apdik T, Tomlin R, Deng Y, Gonzalez-Peralta R, Schilsky M. P12 Effect of liver disease, neurological disease and mental health issues on quality of life in patients with wilson disease. Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.23.Peer-Reviewed Original ResearchMental health issuesWilson's diseaseHealth issuesSeverity of liverMental health QOLPhysical health QoLReview of imagingP-QOL scoresQuality of lifeFIB4 scoreAdult patientsRegistry studyNeurological assessmentPhysical health issuesChronic diseasesOutcome measuresPatientsNeurological diseasesWD patientsQoLAssess qualityDiseaseCirrhosisSignificant differencesScoresP13 Major depressive disorder in patients with wilson’s disease: relationship with liver disease, neurological disease and quality of life
Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Coskun A, Apdik T, Tomlin R, Deng Y, Schilsky M. P13 Major depressive disorder in patients with wilson’s disease: relationship with liver disease, neurological disease and quality of life. Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.24.Peer-Reviewed Original ResearchMajor depressive disorderQuality of lifeMental health QOLWilson's diseaseNeurological diseasesLiver diseaseDepressive disorderFirst presentationExact testDepression symptomologySeverity of liverLifetime major depressive disorderLiver disease severityFisher's exact testPhysical health QOLSignificant differencesWilcoxon rank sum testMental health problemsRank sum testFIB4 scoreClinical featuresNeurological assessmentPHQ-9PatientsCurrent depressionFRI303 Major depressive disorder in patients with Wilson’s disease: relationship with liver disease, neurological disease and quality of life
Camarata M, Ala A, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Maciejewski K, Song X, Deng Y, Tomlin R, Apdik T, Coskun A, Schilsky M. FRI303 Major depressive disorder in patients with Wilson’s disease: relationship with liver disease, neurological disease and quality of life. Journal Of Hepatology 2020, 73: s550-s551. DOI: 10.1016/s0168-8278(20)31573-7.Peer-Reviewed Original ResearchDeep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease
Wadhwa A, Schaefer S, Gerrard J, Deeb W, Okun MS, Patel A. Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2020, 10: 17. PMID: 32775031, PMCID: PMC7394224, DOI: 10.5334/tohm.62.Peer-Reviewed Original ResearchConceptsDeep brain stimulationParkinson's diseaseEssential tremorHead trialsDBS targetsAction tremorSubthalamic nucleus (STN) DBSThalamus deep brain stimulationLimited evidenceDBS target selectionVentral intermediate nucleusBilateral STNPD patientsDBS treatmentEquivalent efficacyRest tremorMild improvementCurrent evidenceET patientsET tremorBrain stimulationComparative efficacyPatientsExpert consensusTremor reduction257 Bipolar disorder in patients with Wilson disease
Zimbrean P, Rubman S, Maciejewski K, Coskun, Nalamada K, Camarata M, Tomlin R, Patel A, To U, Ala A, Gonzalez-Peralta R, Deng Y, Schilsky M. 257 Bipolar disorder in patients with Wilson disease. Journal Of Psychosomatic Research 2020, 133: 110055. DOI: 10.1016/j.jpsychores.2020.110055.Peer-Reviewed Original Research
2019
Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson’s Disease
Elkouzi A, Tsuboi T, Burns M, Eisinger R, Patel A, Deeb W. Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2019, 9 DOI: 10.5334/tohm.496.Peer-Reviewed Original ResearchStimulation-induced dyskinesiasParkinson's diseaseGPi DBSBilateral GPi DBSGPi stimulationMotor fluctuationsPD patientsTherapeutic benefitSide effectsVentral contactVolume of tissuePatientsDiseaseMore studiesDyskinesiaMotor controlDiffusion tensorSpecific tractsPotential strategyStimulationTherapyTractMRIMajor depressive disorder in patients with Wilson disease
Zimbrean P, Gold S, Nalamada K, Camarata M, Tomlin R, Patel A, Vives-Rodrigues A, Ekong U, Bramford N, Valentino P, To U, Deng Y, Song X, Ala A, Schilsky M. Major depressive disorder in patients with Wilson disease. Journal Of Psychosomatic Research 2019, 121: 148. DOI: 10.1016/j.jpsychores.2019.03.145.Peer-Reviewed Original Research
2018
Deep Brain Stimulation Management of Essential Tremor with Dystonic Features
Patel A, Deeb W, Okun MS. Deep Brain Stimulation Management of Essential Tremor with Dystonic Features. Tremor And Other Hyperkinetic Movements 2018, 8: 557. PMID: 29971197, PMCID: PMC6026276, DOI: 10.7916/d8p85vbq.Peer-Reviewed Original ResearchConceptsGlobus pallidus internusEssential tremorDystonic featuresSubthalamic targetsDiagnosis of ETDBS target selectionUnilateral DBS implantationDystonic posturingChief complaintDystonic tremorGeneralized dystoniaCase reportDBS implantationDBS targetsVentralis intermediusClinician's choiceDystoniaDBS leadAcceptable optionLimited evidenceTremorOptimal targetingVIMRigorous studiesTargetDeep Brain Stimulation Management of Essential Tremor with Dystonic Features
Patel A, Deeb W, Okun M. Deep Brain Stimulation Management of Essential Tremor with Dystonic Features. Tremor And Other Hyperkinetic Movements 2018, 8: 557. DOI: 10.5334/tohm.426.Peer-Reviewed Original ResearchGlobus pallidus internusEssential tremorDystonic featuresSubthalamic targetsDiagnosis of ETDBS target selectionUnilateral DBS implantationDystonic posturingChief complaintDystonic tremorGeneralized dystoniaCase reportDBS implantationDBS targetsVentralis intermediusClinician's choiceDystoniaDBS leadAcceptable optionLimited evidenceTremorOptimal targetingVIMRigorous studiesTarget
2017
Management of Elevated Therapeutic Impedances on Deep Brain Stimulation Leads
Deeb W, Patel A, Okun M, Gunduz A. Management of Elevated Therapeutic Impedances on Deep Brain Stimulation Leads. Tremor And Other Hyperkinetic Movements 2017, 7: 493. DOI: 10.5334/tohm.370.Peer-Reviewed Original ResearchVelopharyngeal Dystonia: An Unusual Focal Task-specific Dystonia?
Patel A, Sulica L, Frucht S. Velopharyngeal Dystonia: An Unusual Focal Task-specific Dystonia? Tremor And Other Hyperkinetic Movements 2017, 7: 365. DOI: 10.5334/tohm.353.Peer-Reviewed Original ResearchVelopharyngeal dysfunctionFocal task-specific dystoniaTask-specific dystoniaTask-specific movement disorderAnticholinergic medicationsNasal airwayAnatomical abnormalitiesMovement disordersTreatment responseUnrecognized etiologyPharyngeal musculatureDystoniaVoice disordersDysfunctionDisordersMedicationsPatientsAirwayEtiologyAbnormalitiesPalateSpeech patternsDemoralization in Parkinson Disease (P5.010)
Koo B, Chow C, Shah D, Khan F, Derlein D, Steinberg B, Patel A, Louis E, de Figueiredo J. Demoralization in Parkinson Disease (P5.010). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p5.010.Peer-Reviewed Original ResearchDeep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression
Patel AS. Deep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression. Tremor And Other Hyperkinetic Movements 2017, 7: 447. PMID: 28428905, PMCID: PMC5395677, DOI: 10.7916/d8kd23nz.Peer-Reviewed Original ResearchGlobus pallidus internaSTN stimulationDisease patientsSubthalamic nucleusParkinson's diseaseAdvanced Parkinson's disease (PD) patientsSignificant short-term improvementsAdvanced Parkinson's diseasePD motor symptomsParkinson's disease patientsShort-term improvementSignificant tremor reductionSTN-DBSMotor symptomsPD patientsRefractory tremorComorbid depressionDBS targetsPD tremorMood disordersBilateral DBSInsufficient evidencePatientsTremor reductionSignificant depressionDeep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression
Patel A. Deep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression. Tremor And Other Hyperkinetic Movements 2017, 7: 447. DOI: 10.5334/tohm.369.Peer-Reviewed Original ResearchGlobus pallidus internaSTN stimulationDisease patientsSubthalamic nucleusParkinson's diseaseAdvanced Parkinson's disease (PD) patientsSignificant short-term improvementsAdvanced Parkinson's diseasePD motor symptomsParkinson's disease patientsShort-term improvementSignificant tremor reductionSTN-DBSMotor symptomsPD patientsRefractory tremorComorbid depressionDBS targetsPD tremorMood disordersBilateral DBSInsufficient evidencePatientsTremor reductionSignificant depressionWhat is the pathway forward for the surgical management of essential tremor?
Louis ED, Patel A, Gerrard JL. What is the pathway forward for the surgical management of essential tremor? Annals Of Neurology 2017, 81: 351-353. PMID: 28195360, PMCID: PMC5366883, DOI: 10.1002/ana.24892.Peer-Reviewed Original Research
2015
Early Use of 60 Hz Frequency Subthalamic Stimulation in Parkinson's Disease: A Case Series and Review.
Ramdhani RA, Patel A, Swope D, Kopell BH. Early Use of 60 Hz Frequency Subthalamic Stimulation in Parkinson's Disease: A Case Series and Review. Neuromodulation : Journal Of The International Neuromodulation Society 2015, 18: 664-9. PMID: 25833008, DOI: 10.1111/ner.12288.Peer-Reviewed Original Research