2020
Pediatric unilobar resection in primary ciliary dyskinesia.
Sendon C, Cowles R, Worhunsky D, Hodson D, Morotti R, Bazzy-Asaad A, Esquibies A. Pediatric unilobar resection in primary ciliary dyskinesia. Minerva Pediatrica 2020, 74: 593-599. PMID: 32731729, DOI: 10.23736/s2724-5276.20.05802-8.Peer-Reviewed Original ResearchConceptsPrimary ciliary dyskinesiaSevere lung diseasePulmonary functionLung diseaseCiliary dyskinesiaAggressive medical managementSelective surgical removalQuality of lifeProgressive bronchiectasisUnilobar diseaseProphylactic antibioticsLung resectionAggressive administrationAirway clearanceMedical managementChronic bronchiectasisTherapy optionsLocalized bronchiectasisSurgical removalChronic infectionBronchiectasisRare caseAlternative treatmentNutritional statusNecrotic areas
2018
Opportunities on the road to value‐based payment for children with chronic respiratory disease
Kevill KA, Bazzy‐Asaad A, Pati S. Opportunities on the road to value‐based payment for children with chronic respiratory disease. Pediatric Pulmonology 2018, 54: 105-116. PMID: 30561848, DOI: 10.1002/ppul.24175.Peer-Reviewed Original ResearchFamily‐based study reveals decreased abundance of sputum Granulicatella in asthmatics
Wang L, de Ángel Solá D, Mao Y, Bielecki P, Zhu Y, Sun Z, Shan L, Flavell R, Bazzy‐Asaad A, DeWan A. Family‐based study reveals decreased abundance of sputum Granulicatella in asthmatics. Allergy 2018, 73: 1918-1921. PMID: 29862523, PMCID: PMC6586473, DOI: 10.1111/all.13493.Peer-Reviewed Original Research
2016
Official American Thoracic Society Clinical Practice Guidelines: Diagnostic Evaluation of Infants with Recurrent or Persistent Wheezing
Ren CL, Esther CR, Debley JS, Sockrider M, Yilmaz O, Amin N, Bazzy-Asaad A, Davis SD, Durand M, Ewig JM, Yuksel H, Lombardi E, Noah TL, Radford P, Ranganathan S, Teper A, Weinberger M, Brozek J, Wilson KC. Official American Thoracic Society Clinical Practice Guidelines: Diagnostic Evaluation of Infants with Recurrent or Persistent Wheezing. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 356-373. PMID: 27479061, DOI: 10.1164/rccm.201604-0694st.Peer-Reviewed Original ResearchConceptsGrading of RecommendationsPersistent wheezingConditional recommendationEvidence synthesisDiagnostic evaluationClinical questionsFood avoidanceInfant pulmonary function testingLow-quality evidenceUpper gastrointestinal radiographyPulmonary function testingEvaluation of infantsGuideline development committeeAmerican Thoracic SocietyPaucity of evidenceStandard therapyAllergy testingBronchoalveolar lavageCase seriesClinical outcomesGastrointestinal radiographyAdditional researchFunction testingPatient populationGastrointestinal scintigraphyBiochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia
Montgomery AM, Bazzy-Asaad A, Asnes JD, Bizzarro MJ, Ehrenkranz RA, Weismann CG. Biochemical Screening for Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. Neonatology 2016, 109: 190-194. PMID: 26780635, DOI: 10.1159/000442043.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaPulmonary hypertensionGestational ageNT-proBNPBirth weightBiochemical markersPreterm infantsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptidePresence of PHCross-sectional pilot studyNitric oxideWeeks gestational ageSuch biochemical markersEchocardiographic evidenceScreening echocardiogramsWeeks CGANatriuretic peptideCitrulline levelsInfantsArginine levelsPrecursor citrullineLarger studyEchocardiogramPilot study
2014
Association between right ventricular dysfunction and restrictive lung disease in childhood cancer survivors as measured by quantitative echocardiography
Patel A, Weismann C, Weiss P, Russell K, Bazzy‐Asaad A, Kadan‐Lottick N. Association between right ventricular dysfunction and restrictive lung disease in childhood cancer survivors as measured by quantitative echocardiography. Pediatric Blood & Cancer 2014, 61: 2059-2064. PMID: 25130668, DOI: 10.1002/pbc.25157.Peer-Reviewed Original ResearchConceptsRestrictive lung diseaseChildhood cancer survivorsLung diseaseCancer survivorsIsovolumetric accelerationRV dysfunctionRV functionVentricular dysfunctionMean ageTricuspid annular plane systolic excursionQuantitative echocardiographyAnnular plane systolic excursionEarly RV dysfunctionLower tissue DopplerRestrictive pulmonary impairmentSubclinical RV dysfunctionRight ventricular dysfunctionLeft ventricular dysfunctionPulmonary function testsRight ventricular functionParticipants' mean ageMeasures of contractilityLarger study populationLymphoma/leukemiaThoracic radiation
2011
Unusual pulmonary findings in mucolipidosis II
Ishak M, Zambrano EV, Bazzy‐Asaad A, Esquibies AE. Unusual pulmonary findings in mucolipidosis II. Pediatric Pulmonology 2011, 47: 719-721. PMID: 22162509, DOI: 10.1002/ppul.21599.Peer-Reviewed Original Research
2010
Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare setting
Tolomeo C, Bazzy‐Asaad A. Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare setting. Pediatric Pulmonology 2010, 45: 656-660. PMID: 20578067, DOI: 10.1002/ppul.21233.Peer-Reviewed Original ResearchConceptsTracheostomy tubeSecond caregiverDischarge databaseCaregiver participationMedical/nursing careCaregiver responsesGuardians/parentsParents/guardiansUnivariate analysisNursing careAnticipatory guidanceRespite servicesHomecare settingPrimary caregiversPilot studyHome settingCaregiversSecondary caregiversConvenience sampleCareChildrenInfantsSpecial training programsTraining programHomePulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia
Esquibies AE, Zambrano E, Ziai J, Kesebir D, Touloukian RJ, Egan ME, Reyes‐Múgica M, Bazzy‐Asaad A. Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia. Pediatric Pulmonology 2010, 45: 202-204. PMID: 20054858, DOI: 10.1002/ppul.21148.Peer-Reviewed Original Research
2009
Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease
Pashankar FD, Carbonella J, Bazzy‐Asaad A, Friedman A. Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease. British Journal Of Haematology 2009, 144: 736-741. PMID: 19055665, DOI: 10.1111/j.1365-2141.2008.07501.x.Peer-Reviewed Original ResearchConceptsTricuspid regurgitant jet velocityElevated pulmonary artery pressurePulmonary artery pressureSickle cell diseaseArtery pressureCell diseaseHigher tricuspid regurgitant jet velocityObstructive sleep apneaRegurgitant jet velocityRight ventricular pressureLowest oxygen saturationBorderline elevationCardiopulmonary evaluationInitial echocardiogramRepeat echocardiogramPulmonary hypertensionLower hemoglobinSleep apneaPersistent elevationRisk factorsVentricular pressureIntrapatient variabilityOxygen saturationEchocardiogramPatients
2008
Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep QuestionnairePrevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease
Pashankar FD, Carbonella J, Bazzy-Asaad A, Friedman A. Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease. Pediatrics 2008, 121: 777-782. PMID: 18381543, DOI: 10.1542/peds.2007-0730.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionAnemia, Sickle CellChildChild, PreschoolCohort StudiesComorbidityFemaleFollow-Up StudiesHumansHypertension, PulmonaryMaleMass ScreeningPrevalenceProspective StudiesPulmonary Wedge PressureRisk AssessmentSeverity of Illness IndexSex DistributionSurvival AnalysisTricuspid Valve InsufficiencyUltrasonography, Doppler, TranscranialConceptsTricuspid regurgitant jet velocityElevated pulmonary artery pressureElevated tricuspid regurgitant jet velocityPulmonary artery pressureRegurgitant jet velocityTranscranial Doppler examinationArtery pressurePulmonary hypertensionDoppler examinationSickle cell diseaseRisk factorsCell diseaseExact testPeak tricuspid regurgitant jet velocityPulmonary artery systolic pressureHigh pulmonary artery pressureComprehensive clinic visitModerate pulmonary hypertensionRight outflow obstructionAcute chest syndromeMild pulmonary hypertensionPercent of patientsChronic blood transfusionsHigher platelet countsLowest oxygen saturationA Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome
Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O’Connor C, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ. A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome. The Journal Of Immunology 2008, 180: 601-608. PMID: 18097062, DOI: 10.4049/jimmunol.180.1.601.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchopulmonary DysplasiaCorticosteroneDisease Models, AnimalHumansInfant, NewbornIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMiceMice, KnockoutNeovascularization, PhysiologicPneumoniaPulmonary Surfactant-Associated ProteinsRespiratory Distress Syndrome, NewbornVascular Endothelial Growth Factor AConceptsMacrophage migration inhibitory factorRespiratory distress syndromeNeonatal respiratory distress syndromeMigration inhibitory factorEmbryonic day 18Lung maturationDistress syndromeHuman neonatesDay 18Inhibitory factorEarly saccular stageLungs of pupsNewborn lung diseaseFetal lung maturationVascular endothelial growth factorEmbryonic day 19.5Pulmonary epithelial cellsEndothelial growth factorMIF deficiencyMIF levelsWild-type controlsBronchopulmonary dysplasiaLung diseasePulmonary developmentHistological evaluation
2001
Safety of inhaled corticosteroids in children with asthma
Bazzy-Asaad A. Safety of inhaled corticosteroids in children with asthma. Current Opinion In Pediatrics 2001, 13: 523-527. PMID: 11753100, DOI: 10.1097/00008480-200112000-00005.Peer-Reviewed Original ResearchConceptsModerate dosesChronic childhood asthmaUltimate adult heightMainstay of therapyUse of ICSAdrenal suppressionAsthma controlAdrenal functionChildhood asthmaGrowth retardationAdult heightAsthmaLong-term studiesDrugsCorticosteroidsChildrenDosesInitial decreaseGrowth velocitySafetyProper monitoringComplicationsGlucocorticoidsTherapyMainstay