2008
A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome
Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O’Connor C, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ. A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome. The Journal Of Immunology 2008, 180: 601-608. PMID: 18097062, DOI: 10.4049/jimmunol.180.1.601.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchopulmonary DysplasiaCorticosteroneDisease Models, AnimalHumansInfant, NewbornIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMiceMice, KnockoutNeovascularization, PhysiologicPneumoniaPulmonary Surfactant-Associated ProteinsRespiratory Distress Syndrome, NewbornVascular Endothelial Growth Factor AConceptsMacrophage migration inhibitory factorRespiratory distress syndromeNeonatal respiratory distress syndromeMigration inhibitory factorEmbryonic day 18Lung maturationDistress syndromeHuman neonatesDay 18Inhibitory factorEarly saccular stageLungs of pupsNewborn lung diseaseFetal lung maturationVascular endothelial growth factorEmbryonic day 19.5Pulmonary epithelial cellsEndothelial growth factorMIF deficiencyMIF levelsWild-type controlsBronchopulmonary dysplasiaLung diseasePulmonary developmentHistological evaluation
2007
δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia
Chao D, Bazzy‐Asaad A, Balboni G, Xia Y. δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. Journal Of Cellular Physiology 2007, 212: 60-67. PMID: 17373650, DOI: 10.1002/jcp.21000.Peer-Reviewed Original ResearchConceptsMicro-opioid receptorOxygen-glucose deprivationOpioid receptorsDelta-opioid receptor activationHypoxic/ischemic stressPresence of paxillineHypoxia-induced increaseH-Dmt-TicDOR activityDOR antagonistDOR agonistsCortical slicesAcute hypoxiaMOR agonistsChannel blockersDOR effectsIschemic stressDerangementReceptor activationCortexDADLEReceptorsUnderlying mechanismChannel activityAgonists