2023
In silico design and validation of a time-varying PID controller for an artificial pancreas with intraperitoneal insulin delivery and glucose sensing
Libera A, Toffanin C, Drecogna M, Galderisi A, Pillonetto G, Cobelli C. In silico design and validation of a time-varying PID controller for an artificial pancreas with intraperitoneal insulin delivery and glucose sensing. APL Bioengineering 2023, 7: 026105. PMID: 37229215, PMCID: PMC10205143, DOI: 10.1063/5.0145446.Peer-Reviewed Original ResearchIP insulin deliveryInsulin deliveryPeritoneal spaceMeal announcementChronic autoimmune diseaseInsulin kineticsParadigm of treatmentBeta-cell functionIntraperitoneal insulin deliveryType 1 diabetesInpatient trialPeripheral hyperinsulinemiaMacrovascular complicationsGlycemic controlTwo-compartment modelInsulin replacementAutoimmune diseasesInsulin delivery systemsInsulin secretionDaily burdenInsulin pumpAid useCell functionArtificial pancreasDisease
2017
Metabolomics reveals new metabolic perturbations in children with type 1 diabetes
Galderisi A, Pirillo P, Moret V, Stocchero M, Gucciardi A, Perilongo G, Moretti C, Monciotti C, Giordano G, Baraldi E. Metabolomics reveals new metabolic perturbations in children with type 1 diabetes. Pediatric Diabetes 2017, 19: 59-67. PMID: 28401628, DOI: 10.1111/pedi.12524.Peer-Reviewed Original ResearchConceptsBody mass indexType 1 diabetesHealthy controlsPubertal statusExcess of cortisolMetabolome of childrenPediatric diabetes clinicMacrovascular complicationsDiabetes clinicDisease durationNeuronal damagePediatric patientsClinical featuresMass indexCase groupTryptophan catabolitesHealthy peersUrinary metabolitesUrinary samplesBacterial productsT1DUntargeted metabolomics approachMetabolic perturbationsDiabetesPatients