Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomicsClinical features of neonatal COVID-19
Galderisi A, Lista G, Cavigioli F, Trevisanuto D. Clinical features of neonatal COVID-19. Seminars In Fetal And Neonatal Medicine 2023, 28: 101430. PMID: 37005209, PMCID: PMC10036147, DOI: 10.1016/j.siny.2023.101430.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSARS-CoV-2 infectionClinical featuresNeonatal COVID-19Infected mothersHealthy newbornsPsychological health problemsEfforts of cliniciansEpidemiological dataHealth problemsAge groupsInfectionFirst dayHealthcare systemCOVID-19COVID-19 pandemicNewbornsDifferential effectsEntire populationAdditional burdenComorbiditiesPandemicComplicationsNeonatesCliniciansMassive research effort