2023
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptionsTemperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureHigh-Risk Pulmonary Embolism: Management for the Intensivist
Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.Peer-Reviewed Original ResearchConceptsHigh-risk pulmonary embolismHigh-risk PE patientsPulmonary embolismRisk stratificationPE patientsTreatment optionsRisk pulmonary embolismMassive pulmonary embolismIntensivist’s perspectiveReperfusion therapySupportive careAcute managementPatientsIntensivistsSupport optionsEmbolismHigh rateCarePhysiological consequencesOutcomesTreatmentOptionsStratificationMorbidityTherapyValidation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest
Kim N, Kitlen E, Garcia G, Khosla A, Miller P, Johnson J, Wira C, Greer D, Gilmore E, Beekman R. Validation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest. Resuscitation 2023, 188: 109832. PMID: 37178901, DOI: 10.1016/j.resuscitation.2023.109832.Peer-Reviewed Original ResearchConceptsPoor neurologic outcomeUnited States cohortHospital cardiac arrestOHCA patientsNeurologic outcomeCardiac arrestPost-cardiac arrest syndromePoor neurological outcomeScore predictive abilityHospital mortalityNeurological outcomeUnResponsiveness (FOUR) scorePoor outcomeRetrospective studyAccurate outcome predictionPrognostic performanceFull OutlineDeLong testOutcome predictionPatientsMortalityOutcomesScoresCohortPredictive abilityLonger-Term Outcomes Following Mechanical Thrombectomy for Intermediate- and High-Risk Pulmonary Embolism: 6-Month FLASH Registry Results
Longer-Term Outcomes Following Mechanical Thrombectomy for Intermediate- and High-Risk Pulmonary Embolism: 6-Month FLASH Registry Results Khandhar, Sameer et al. Journal of the Society for Cardiovascular Angiography & Interventions, Volume 2, Issue 4, 101000Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEmergent Pulmonary Embolism Management In Hospital Practice, From Hyperacute to Follow-Up Care, Chapter 5 Systemic Thrombolysis in Acute Pulmonary Embolism
Emergent Pulmonary Embolism Management in Hospital Practice Colm McCabe (Royal Brompton Hospital, UK) and Aaron Waxman (Brigham and Women's Hospital, USA) Default Book Series. March 2023ChaptersNavigating the Complexity of High-Risk Pulmonary Embolism—Is Mechanical Thrombectomy the Answer We Need?
Navigating the Complexity of High-Risk Pulmonary Embolism—Is Mechanical Thrombectomy the Answer We Need? Mojibian, Hamid R., Khanjan Shah, Akhil Khosla Journal of the Society for Cardiovascular Angiography & Interventions, Volume 3, Issue 1, 101178Commentaries, Editorials and LettersSystemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics
Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics Stella M. Savarimuthu, Inderjit Singh, and Akhil Khosla Emergent Pulmonary Embolism Management in Hospital Practice. March 2023, 59-69Chapters
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingRight heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations
Khosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.Peer-Reviewed Original ResearchRight heart thrombusConcomitant pulmonary embolismPulmonary embolismHeart thrombusTreatment strategiesLimited clinical dataMultiple treatment strategiesMultiple medical specialtiesSystemic thrombolysisSurgical therapyExact incidenceRisk stratificationPoor outcomeUse of pointClinical dilemmaClinical dataTreatment considerationsPE managementCare ultrasoundMultiple specialtiesMedical specialtiesThrombusSpecialtiesAnticoagulationThrombolysisCatheter-directed embolectomy for massive pulmonary embolism in a pediatric patient
Chan SM, Gaupp F, Lee JM, Pollak JS, Khosla A. Catheter-directed embolectomy for massive pulmonary embolism in a pediatric patient. SAGE Open Medical Case Reports 2022, 10: 2050313x221112361. PMID: 35847425, PMCID: PMC9280839, DOI: 10.1177/2050313x221112361.Peer-Reviewed Original ResearchMassive pulmonary embolismPulmonary embolismPediatric patientsPulmonary Embolism Response TeamPediatric pulmonary embolismSystemic thrombolyticsPediatric populationTreatment paradigmEffective therapyAdult studiesInclusion criteriaHigh riskEmbolismAdult populationEmbolectomyPatientsResponse teamsMore researchChildrenRiskAnticoagulationThrombolyticsTherapyPopulationMortality
2021
A commentary on: Heart rate and mortality in patients with acute symptomatic pulmonary embolism
Khosla A.; A commentary on: Heart rate and mortality in patients with acute symptomatic pulmonary embolism. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/heart-rate-and-mortality-in-acute-pulmonary-embolism/123603/65/20/1Commentaries, Editorials and Letters
2020
Adrenal Insufficiency
Khosla A, Ahasic A. Adrenal Insufficiency. 2020, 417-421. DOI: 10.1007/978-3-030-26710-0_54.Peer-Reviewed Original ResearchCritical illness-related corticosteroid insufficiencyAdrenal insufficiencyAdrenocorticotropic hormoneAcute critical illnessRelative adrenal insufficiencyGlucocorticoid replacement therapyCause of shockMainstay of treatmentPrimary adrenal insufficiencyExogenous adrenocorticotropic hormoneCorticosteroid insufficiencyMineralocorticoid replacementCritical illnessSupportive careFluid resuscitationHypothalamic disorderIll patientsACTH levelsReplacement therapySalt repletionSerum cortisolCortisol levelsInsufficiencyPatientsEtiologyCritical Illness Related Corticosteroid Insufficiency (CIRCI)
Khosla A, Ahasic A. Critical Illness Related Corticosteroid Insufficiency (CIRCI). 2020, 423-428. DOI: 10.1007/978-3-030-26710-0_55.Peer-Reviewed Original ResearchCritical illness related corticosteroid insufficiencyHypothalamic pituitary adrenal axisCorticosteroid insufficiencyCritical illness-related corticosteroid insufficiencyACTH stimulation testingRelative adrenal insufficiencyCardiopulmonary bypass surgeryIntensive care unitPituitary-adrenal axisRefractory hypotensionAdrenal insufficiencyBypass surgeryCritical illnessSystemic inflammationIll patientsSeptic shockCare unitGlucocorticoid activityStimulation testingAdrenal axisCardiac arrestConventional therapyPatient's illnessSuch illnessesCortisol measurements
2019
Adrenal Insufficiency, Critical Illness Related Corticosteroid Insufficiency
Khosla A, Adrenal Insufficiency, Critical Illness Related Corticosteroid Insufficiency. In: Evidence-Based Critical Care - A Case Study Approach, Hyzy Robert; Springer 2nd ed. Springer Cham: 978-3-030-267094 Published: 25 March 2020, p. 417-422, 423-428Chapters
2017
Calculated decisions: DECAF Score for acute exacerbation of chronic obstructive pulmonary disease (COPD)
Khosla A, Scatena R. Calculated decisions: DECAF Score for acute exacerbation of chronic obstructive pulmonary disease (COPD). Emergency Medicine Practice 2017, 19: 3-4. PMID: 29068639.Peer-Reviewed Original Research
2014
Hypoglycemia in the Hospital: Systems-Based Approach to Recognition, Treatment, and Prevention
Varlamov EV, Kulaga ME, Khosla A, Prime DL, Rennert NJ. Hypoglycemia in the Hospital: Systems-Based Approach to Recognition, Treatment, and Prevention. Hospital Practice 2014, 42: 163-172. PMID: 25502140, DOI: 10.3810/hp.2014.10.1153.Peer-Reviewed Original ResearchConceptsInpatient diabetes careImmediate adverse reactionsUnfavorable clinical outcomeAmerican Diabetes AssociationTransitions of careInpatient glycemic controlHealth care costsAdditional hospital resourcesCoordination of nutritionQuality improvement effortsAcute illnessGlycemic controlHospitalized patientsClinical outcomesPredispose patientsDiabetes AssociationHypoglycemic eventsDiabetes careAdverse reactionsEndocrine SocietyInsulin administrationPatient educationHospital resourcesHypoglycemiaHospital routine