2023
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptionsHigh-Risk Pulmonary Embolism: Management for the Intensivist
Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.Peer-Reviewed Original ResearchConceptsHigh-risk pulmonary embolismHigh-risk PE patientsPulmonary embolismRisk stratificationPE patientsTreatment optionsRisk pulmonary embolismMassive pulmonary embolismIntensivist’s perspectiveReperfusion therapySupportive careAcute managementPatientsIntensivistsSupport optionsEmbolismHigh rateCarePhysiological consequencesOutcomesTreatmentOptionsStratificationMorbidityTherapyValidation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest
Kim N, Kitlen E, Garcia G, Khosla A, Miller P, Johnson J, Wira C, Greer D, Gilmore E, Beekman R. Validation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest. Resuscitation 2023, 188: 109832. PMID: 37178901, DOI: 10.1016/j.resuscitation.2023.109832.Peer-Reviewed Original ResearchConceptsPoor neurologic outcomeUnited States cohortHospital cardiac arrestOHCA patientsNeurologic outcomeCardiac arrestPost-cardiac arrest syndromePoor neurological outcomeScore predictive abilityHospital mortalityNeurological outcomeUnResponsiveness (FOUR) scorePoor outcomeRetrospective studyAccurate outcome predictionPrognostic performanceFull OutlineDeLong testOutcome predictionPatientsMortalityOutcomesScoresCohortPredictive ability
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingCatheter-directed embolectomy for massive pulmonary embolism in a pediatric patient
Chan SM, Gaupp F, Lee JM, Pollak JS, Khosla A. Catheter-directed embolectomy for massive pulmonary embolism in a pediatric patient. SAGE Open Medical Case Reports 2022, 10: 2050313x221112361. PMID: 35847425, PMCID: PMC9280839, DOI: 10.1177/2050313x221112361.Peer-Reviewed Original ResearchMassive pulmonary embolismPulmonary embolismPediatric patientsPulmonary Embolism Response TeamPediatric pulmonary embolismSystemic thrombolyticsPediatric populationTreatment paradigmEffective therapyAdult studiesInclusion criteriaHigh riskEmbolismAdult populationEmbolectomyPatientsResponse teamsMore researchChildrenRiskAnticoagulationThrombolyticsTherapyPopulationMortality
2020
Adrenal Insufficiency
Khosla A, Ahasic A. Adrenal Insufficiency. 2020, 417-421. DOI: 10.1007/978-3-030-26710-0_54.Peer-Reviewed Original ResearchCritical illness-related corticosteroid insufficiencyAdrenal insufficiencyAdrenocorticotropic hormoneAcute critical illnessRelative adrenal insufficiencyGlucocorticoid replacement therapyCause of shockMainstay of treatmentPrimary adrenal insufficiencyExogenous adrenocorticotropic hormoneCorticosteroid insufficiencyMineralocorticoid replacementCritical illnessSupportive careFluid resuscitationHypothalamic disorderIll patientsACTH levelsReplacement therapySalt repletionSerum cortisolCortisol levelsInsufficiencyPatientsEtiology