2024
The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging
Pham H, Thompson-Felix T, Czamara D, Rasmussen J, Lombroso A, Entringer S, Binder E, Wadhwa P, Buss C, O'Donnell K. The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging. Cell Metabolism 2024, 36: 877-878. PMID: 38521058, DOI: 10.1016/j.cmet.2024.02.016.Peer-Reviewed Original Research
2023
The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS
Alemany-Navarro M, Tubío-Fungueiriño M, Almeida S, Cruz R, Lombroso A, Real E, Soria V, Bertolín S, Fernández-Prieto M, Alonso P, Menchón J, Carracedo A, Segalàs C. The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS. Journal Of Affective Disorders 2023, 333: 365-376. PMID: 37094658, DOI: 10.1016/j.jad.2023.04.060.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide polymorphismsSuggestive signalsCase/control genome-wide association studyPreliminary genome-wide association studyGenome-wide levelGenome-wide significanceGenomic basisComplex traitsGenomic regionsWhole genomeGenetic basisAssociation studiesGenetic characterizationAssociation of SNPsNucleotide polymorphismsGenomicsTraitsGenomeGenesNeuropsychological traitsPolymorphismPromising avenueSignalsOCD casesSystematic review and meta-analysis: Season of birth and schizophrenia risk
Coury S, Lombroso A, Avila-Quintero V, Taylor J, Flores J, Szejko N, Bloch M. Systematic review and meta-analysis: Season of birth and schizophrenia risk. Schizophrenia Research 2023, 252: 244-252. PMID: 36682315, DOI: 10.1016/j.schres.2022.12.016.Peer-Reviewed Original ResearchConceptsRisk of schizophreniaSummer birthWinter birthSystematic reviewBirth monthVitamin D deficiencyStratified subgroup analysisSchizophrenia riskEtiological risk factorsMonth of birthD deficiencySeason of birthEtiologic causesSubgroup analysisVirus exposureRisk factorsSchizophreniaMonthsBirthSignificant differencesRiskAssociation
2022
Cannabis-based medicine in treatment of patients with Gilles de la Tourette syndrome
Szejko N, Saramak K, Lombroso A, Müller-Vahl K. Cannabis-based medicine in treatment of patients with Gilles de la Tourette syndrome. Neurologia I Neurochirurgia Polska 2022, 56: 28-38. PMID: 34708399, DOI: 10.5603/pjnns.a2021.0081.Peer-Reviewed Original ResearchConceptsCannabis-based medicinesTourette syndromeFirst-line treatmentIntolerable side effectsPresence of motorChildhood-onset disordersLine treatmentTic reductionVocal ticsTherapeutic approachesSide effectsAlternative treatmentElectronic databasesAmerican AcademyBehavioral therapyGilles deOnset disordersEuropean SocietySearch termsRelevant studiesPatientsSyndromeTreatmentSignificant numberAntipsychoticsThe effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis
Farhat LC, Flores JM, Behling E, Avila-Quintero VJ, Lombroso A, Cortese S, Polanczyk GV, Bloch MH. The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis. Molecular Psychiatry 2022, 27: 1562-1572. PMID: 35027679, DOI: 10.1038/s41380-021-01391-9.Peer-Reviewed Original ResearchConceptsFixed-dose trialAttention-deficit/hyperactivity disorderDose-limiting adverse eventsChildren/adolescentsAdverse eventsFlexible-dose trialTerms of efficacyClinical practiceHigh dosesFlexible dose designIntolerable adverse eventsHyperactivity disorderIncremental benefitLikelihood of discontinuationADHD symptomsLarge systematic reviewSchool-aged children/adolescentsFlexible titrationPotential long-term effectsSymptom controlTreatment discontinuationClinical outcomesStimulant dosesDaily dosesClinical guidelines
2021
Genomics of Obsessive-Compulsive Disorder—Toward Personalized Medicine in the Era of Big Data
Szejko N, Dunalska A, Lombroso A, McGuire JF, Piacentini J. Genomics of Obsessive-Compulsive Disorder—Toward Personalized Medicine in the Era of Big Data. Frontiers In Pediatrics 2021, 9: 685660. PMID: 34746045, PMCID: PMC8564378, DOI: 10.3389/fped.2021.685660.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumCommon disease-common variant hypothesisCommon variant hypothesisContext of genomicsGenetic codeGenetic association studiesMultiple genesAssociation studiesGenomics ConsortiumPolygenic risk scoresGenomicsGenetic contributionMendelian randomizationPolygenic disorderPersonalized medicineObsessive-compulsive disorderUK BiobankNew pathwayOCD pathogenesisAvailable databasesGenesDisease-specific databasesChina Kadoorie BiobankPathwayCo-existing pathologyParental Age and the Risk for Alzheimer’s Disease in Offspring: Systematic Review and Meta-Analysis
Szejko N, Macul Ferreira de Barros P, Avila-Quintero VJ, Lombroso A, Bloch MH. Parental Age and the Risk for Alzheimer’s Disease in Offspring: Systematic Review and Meta-Analysis. Dementia And Geriatric Cognitive Disorders Extra 2021, 11: 140-150. PMID: 34178019, PMCID: PMC8216010, DOI: 10.1159/000515523.Peer-Reviewed Original ResearchAlzheimer's diseaseSystematic reviewParental ageRisk factorsPaternal ageRisk of ADLate Alzheimer's diseaseAdequate control groupsCohort studyPotential confoundersCommon causeCase controlControl groupElectronic databasesMeta-AnalysisVersion 16Significant associationDown syndromeDifferential riskDiseaseRelevant studiesAgeOlder parentsRiskMethodological limitations
2020
Refractory Gilles de la Tourette Syndrome—Many Pieces That Define the Puzzle
Szejko N, Lombroso A, Bloch MH, Landeros-Weisenberger A, Leckman JF. Refractory Gilles de la Tourette Syndrome—Many Pieces That Define the Puzzle. Frontiers In Neurology 2020, 11: 589511. PMID: 33391155, PMCID: PMC7775596, DOI: 10.3389/fneur.2020.589511.Peer-Reviewed Original Research
2017
Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration
Xiang Y, Tanaka Y, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH. Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Cell Stem Cell 2017, 21: 383-398.e7. PMID: 28757360, PMCID: PMC5720381, DOI: 10.1016/j.stem.2017.07.007.Peer-Reviewed Original ResearchConceptsHuman brain developmentChromatin accessibility dynamicsTransposase-accessible chromatinHigh-throughput sequencing analysisRegion-specific organoidsHuman pluripotent stem cellsRNA sequencing profilingHuman interneuron migrationPluripotent stem cellsRelated lineagesBrain developmentAccessibility dynamicsBulk assaysInterneuron migrationLineage relationshipsOrganoid techniquesSequencing profilingSequencing analysisFunctional neuronsOrganoid developmentStem cellsCortical organoidsOrganoidsBrain organoidsMGE