2024
Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood
Mavrantoni I, Borneman R, Hittelman A, Vash-Margita A. Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood. BMJ Case Reports 2024, 17: e259373. PMID: 39117365, DOI: 10.1136/bcr-2023-259373.Peer-Reviewed Original ResearchConceptsVaginal stenosisClinical follow-upTime of birthDilator usePosterior vaginoplastyAcademic medical centreTertiary care academic medical centreFetal developmentElevated androgensFollow-upMedical historyPenetrative intercourseMedical CentreLong-term effectsLuteomaLaboratory investigationsVaginoplastyPregnancyVaginaStenosisPatientsPsychosocial implicationsVirilisationCystoscopyIntroitus
2022
Feasibility of establishing a multi-center research database using the electronic health record: The PURSUIT network
Vemulakonda VM, Janzen N, Hittelman AB, Deakyne Davies S, Sevick C, Richardson AC, Schissel J, Dash D, Hintz R, Grider R, Adams P, Buck M, King J, Ewing E, Beltran G, Corbett S, Chiang G. Feasibility of establishing a multi-center research database using the electronic health record: The PURSUIT network. Journal Of Pediatric Urology 2022, 18: 788.e1-788.e8. PMID: 35644792, DOI: 10.1016/j.jpurol.2022.05.004.Peer-Reviewed Original ResearchConceptsManual chart reviewChart reviewMulti-centre researchEligible patientsClinic visitsStructured data elementsRadiology resultsElectronic health record toolsInitial clinic visitPediatric urology practiceElectronic health recordsActive medicationClinic encountersRenal ultrasoundVesicoureteral refluxCongenital hydronephrosisStudy criteriaOperative notesUrology practicePrior historyEpic EHRPhysician documentationResearch DatabasePhysician utilizationPatients
2021
Urology Residency Training in Medically Underserved Areas Through the Integration of a Federally Qualified Health Center Rotation
Javier-DesLoges JF, Segal D, Khan A, Abello A, Motamedinia P, Hittelman AB, Rosoff J, Stroup R, Leapman MS. Urology Residency Training in Medically Underserved Areas Through the Integration of a Federally Qualified Health Center Rotation. Urology 2021, 149: 52-57. PMID: 33421443, DOI: 10.1016/j.urology.2020.11.057.Peer-Reviewed Original ResearchConceptsHealth professional shortage areasMedically Underserved AreasUnderserved areasUrology residency trainingResidency trainingMajority of residentsQualified health centersRetrospective reviewUnique patientsUrologic carePatient visitsHealth centersFavorable satisfactionPatientsFQHCsShortage areasCommunity-based organizationsUrology residentsExposureResidentsCystoscopySurgeryReviewClinicMajority
2020
Antireflux Surgery at National Surgical Quality Improvement Program-Pediatric Hospitals.
Johnson EK, Chalmers DJ, Nelson CP, Li I, Iwaniuk M, Grant C, Byrd C, Rangel SJ, Saito JM, Barnhart DC, Hall BL, Vemulakonda VM, Groth TW, Ellison JS, Janzen NK, Hittelman AB, DiCarlo HN, Merguerian PA, Tanaka ST, Prasad MM. Antireflux Surgery at National Surgical Quality Improvement Program-Pediatric Hospitals. Journal Of Urology 2020, 205: 1189-1198. PMID: 33207139, DOI: 10.1097/ju.0000000000001439.Peer-Reviewed Original ResearchConceptsEmergency department visitsProcedure-specific variablesAntireflux surgeryEndoscopic injectionDepartment visitsUnplanned proceduresNational Surgical Quality Improvement Program-Pediatric dataNational Surgical Quality Improvement Program-PediatricStandardized perioperative pathwayHalf of patientsShort-term complicationsUrinary tract infectionShort-term outcomesContemporary practice patternsHigher reflux gradePerioperative pathwayPostoperative occurrenceReflux gradeTract infectionsAntireflux procedureUrine culturePractice patternsProcedure distributionPatientsHospital
1999
Differential regulation of glucocorticoid receptor transcriptional activation via AF‐1‐associated proteins
Hittelman A, Burakov D, Iñiguez‐Lluhí J, Freedman L, Garabedian M. Differential regulation of glucocorticoid receptor transcriptional activation via AF‐1‐associated proteins. The EMBO Journal 1999, 18: 5380-5388. PMID: 10508170, PMCID: PMC1171607, DOI: 10.1093/emboj/18.19.5380.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportGene Expression RegulationGlucocorticoidsHeLa CellsHumansNuclear ProteinsProtein BindingReceptors, GlucocorticoidTrans-ActivatorsTranscription FactorsTranscriptional ActivationTwo-Hybrid System TechniquesConceptsTranscriptional enhancementAF-1Regulatory factorsGlucocorticoid receptor transcriptional activationTumor susceptibility gene 101Two-hybrid approachTranscriptional regulatory factorsSusceptibility gene 101Activation functions AF-1AF-2Negative regulatory factorHormone-activated glucocorticoid receptorHormone-dependent mannerModified yeastTranscriptional activationMammalian cellsDRIP complexTarget genesProtein 150Differential regulationGlucocorticoid receptorGR transactivationTransactivationYeastGR ligandsDistinct Glucocorticoid Receptor Transcriptional Regulatory Surfaces Mediate the Cytotoxic and Cytostatic Effects of Glucocorticoids
Rogatsky I, Hittelman A, Pearce D, Garabedian M. Distinct Glucocorticoid Receptor Transcriptional Regulatory Surfaces Mediate the Cytotoxic and Cytostatic Effects of Glucocorticoids. Molecular And Cellular Biology 1999, 19: 5036-5049. PMID: 10373553, PMCID: PMC84339, DOI: 10.1128/mcb.19.7.5036.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCell CycleCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27CyclinsCytotoxicity, ImmunologicDimerizationGlucocorticoidsHumansMicrotubule-Associated ProteinsMifepristoneMutagenesisProto-Oncogene Proteins c-bcl-2Receptors, GlucocorticoidTranscriptional ActivationTumor Cells, CulturedTumor Suppressor ProteinsConceptsTranscriptional repression functionRepression of Bcl2Saos2 cellsTranscriptional regulatory mechanismsAF-1Transcriptional activation functionTransactivation-deficient mutantAF-2Cyclin-dependent kinase inhibitorRepression functionTranscriptional activatorGlucocorticoid receptorRegulatory surfaceTarget genesCell contextReceptor dimerizationRegulatory mechanismsCytostatic actionHuman osteosarcoma cellsVariety of cellsGR mutantsCytostatic effectMolecular mechanismsCytotoxic effectsU20S cells