2024
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes
Zhou Y, Stevis P, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman M, Olson W, Franklin M. Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes. Nature Communications 2024, 15: 9776. PMID: 39532904, PMCID: PMC11557873, DOI: 10.1038/s41467-024-54124-1.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factor receptorOncostatin MExtracellular assemblyReceptor complexOSM receptorOncostatin M signalingOncostatin M receptorJuxtamembrane domainGp130 bindingCryogenic electron microscopyStructural basisGlycoprotein 130Cryo-EMFamily cytokinesBiological eventsGp130Therapeutic targetComplex formationFactor receptorType IMouse typesReceptorsAssemblyJuxtamembraneMutagenesisDivergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse
Smagris E, Shihanian L, Mintah I, Bigdelou P, Livson Y, Brown H, Verweij N, Hunt C, Johnson R, Greer T, Hartford S, Hindy G, Sun L, Nielsen J, Halasz G, Lotta L, Murphy A, Sleeman M, Gusarova V. Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. PLOS Genetics 2024, 20: e1011179. PMID: 38437227, PMCID: PMC10939284, DOI: 10.1371/journal.pgen.1011179.Peer-Reviewed Original ResearchConceptsAssociation studiesExome-wide association studyHuman genome-wide association studiesGenome-wide association studiesLoss of function variantsFamily enzymesMissense variantsObserved phenotypesFunctional variantsAberrant localizationProtein instabilityAncestry groupsHepatic triglyceride accumulationDivergent rolesLiver phenotypePhysiological functionsTriglyceride accumulationPhenotypeDeletionMouse liverIn vitro studiesHepatic cellsProteinEnzymeKnockout mice
2023
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency
Altarejos J, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert A, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim J, Stevis P, Huang T, Zambrowicz B, Olson W, Godin S, Bradley E, Gewitz A, Baker M, Hench R, Davenport M, Chenevert T, DiPaola F, Yancopoulos G, Murphy A, Herman G, Musser B, Dansky H, Harp J, Gromada J, Sleeman M, Oral E, Olenchock B. Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency. Science Translational Medicine 2023, 15: eadd4897. PMID: 37992152, DOI: 10.1126/scitranslmed.add4897.Peer-Reviewed Original ResearchConceptsLeptin concentrationsBody weightHepatic steatosisAdipose-derived hormone leptinClass 3 obesityCompassionate use treatmentHigher baseline leptinLeptin knockout miceAcceptable safety profileLower leptin concentrationsPresence of leptinHuman monoclonal antibodyLeptin receptor signalingTreatment of individualsPhase 1Baseline leptinLepr signalingLeptin deficiencyMetabolic sequelaeLiver diseaseClinical benefitSafety profileInsulin resistanceBlood glucoseInsulin sensitivity
2008
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome
Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN. The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development 2008, 135: 1713-1723. PMID: 18353862, DOI: 10.1242/dev.015149.Peer-Reviewed Original ResearchAbnormalities, MultipleAnimalsBody Mass IndexBone Morphogenetic ProteinsFertilityGenes, RecessiveGrowth Differentiation Factor 5HumansJointsLimb Deformities, CongenitalMaleMiceMice, Mutant StrainsMusculoskeletal AbnormalitiesMutationReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase-like Orphan ReceptorsSyndrome