Yale/NIDA Neuroproteomics Center
Twenty-five faculty members with an established history of studies of the molecular actions of psychostimulants and psychotropic drugs, as well as of other basic aspects of neurobiology, are working with the W.M. Keck Foundation Biotechnology Resource Laboratory to continually strengthen the Neuroproteomics Center. The theme of the Center, "Proteomics of Altered Signaling in Addiction" brings exceptionally strong Yale programs in proteomics and signal transduction in the brain together with neuroscientists from eight institutions across the country to identify adaptive changes in protein signaling that occur in response to substances of abuse. In addition, the Center provides training in proteomics technologies, sponsors an active pilot projects program directed at acquiring the preliminary data needed to bring novel and highly promising research ideas relevant to the Center's theme to the point where they can successfully compete for NIH and other grant support, and is constantly striving to improve existing and develop new proteomics technologies that can be applied to biological questions related to the actions of drugs of abuse. The Center includes five cores: Protein Profiling and Identification, Biophysics, and Phosphoinositide Analysis; Protein Post-translational Modifications; Targeted Proteomics; Bioinformatics and Biostatistics, and Administration.