Rajiv Radhakrishnan, MBBS, MD, FAPA
Associate Professor Adjunct in PsychiatryDownloadHi-Res Photo
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Additional Titles
Associate Professor, Radiology and Biomedical Imaging
Affiliated Faculty, Yale Institute for Global Health
Contact Info
About
Titles
Associate Professor Adjunct in Psychiatry
Associate Professor, Radiology and Biomedical Imaging; Affiliated Faculty, Yale Institute for Global Health
Appointments
Psychiatry
Associate Professor AdjunctPrimaryRadiology & Biomedical Imaging
Associate Professor on TermSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Interventional Psychiatry Service
- MR Core
- NeuroPET Imaging Program
- PET Core
- Psychiatry
- Radiology & Biomedical Imaging
- Yale Biomedical Imaging Institute
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Institute for Global Health
Education & Training
- MHS
- Yale University (2021)
- MD
- St. John's Medical College (2008)
- MBBS
- St John's Medical College, Medicine (2003)
Board Certifications
Addiction Medicine (Preventive Medicine)
- Certification Organization
- AB of Preventive Medicine
- Original Certification Date
- 2020
Research
Overview
Medical Research Interests
Marijuana Abuse; Psychoses, Substance-Induced; Schizophrenia
Public Health Interests
Mental Health; Substance Use, Addiction
ORCID
0000-0002-8220-655X- View Lab Website
Radhakrishnan Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Rajiv Radhakrishnan's published research.
Publications Timeline
A big-picture view of Rajiv Radhakrishnan's research output by year.
Research Interests
Research topics Rajiv Radhakrishnan is interested in exploring.
Deepak Cyril Dsouza, MBBS, MD
Nabeel Nabulsi, PhD
Sinan Guloksuz, MD, PhD
David Matuskey, MD
Irina Esterlis, PhD
Mika Naganawa, PhD
33Publications
732Citations
Schizophrenia
Marijuana Abuse
Publications
2024
Efficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting.
Santucci M, Ansari M, Nikayin S, Radhakrishnan R, Rhee T, Wilkinson S. Efficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39361411, DOI: 10.4088/jcp.24m15376.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBipolar depressionAcute seriesRisk of affective switchDiagnosis of bipolar depressionRefractory bipolar depressionAcute phaseMADRS scoreAffective switchIntranasal esketamineManic episodesBipolar disorderCohort of patientsAttending psychiatristsSource of morbidityEsketamineSample of patientsIV ketamineMaintenance treatmentDepressionClinical responseHeightened riskClinical outcomesMania/hypomaniaKetamineKetamine/esketamineSubstance use and spine density: a systematic review and meta-analysis of preclinical studies
Oliva H, Prudente T, Nunes E, Cosgrove K, Radhakrishnan R, Potenza M, Angarita G. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular Psychiatry 2024, 29: 2873-2885. PMID: 38561468, PMCID: PMC11894807, DOI: 10.1038/s41380-024-02519-3.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSpine densityPrefrontal cortexSubstance useDrug Self-AdministrationHippocampal spine densityEffects of cocaineSubstance use disordersConvergence of findingsSpine density changesSubstances of abuseMeta-analysis of preclinical studiesNucleus accumbensBehavioral sensitizationSelf-AdministrationBrain mechanismsPreclinical studiesBrain regionsMorphine effectsSynaptic density changesMeta-analysisAmphetamineSynaptic densityCocaineModerate-to-highCortexIn Vivo Synaptic Density in Early Schizophrenia: Are There No Differences or Are They Too Small to Detect?
Radhakrishnan R. In Vivo Synaptic Density in Early Schizophrenia: Are There No Differences or Are They Too Small to Detect? Biological Psychiatry 2024, 95: 605-607. PMID: 38479976, DOI: 10.1016/j.biopsych.2024.01.016.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSynaptic densityA systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders
Hird R, Radhakrishnan R, Tsai J. A systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders. Frontiers In Psychiatry 2024, 14: 1339801. PMID: 38260790, PMCID: PMC10800888, DOI: 10.3389/fpsyt.2023.1339801.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMedication adherenceAssertive community treatmentLong-Acting Injectable MedicationsPsychiatric disordersInjectable medicationsAdherence enhancementCommunity treatmentHomeless adultsSystematic reviewPsychiatric medication adherenceSubstance use disordersFull-text reviewModified therapeutic communityPeer-reviewed journalsInpatient interventionLarge RCTsSelf-designed scaleHomeless individualsOutpatient interventionInpatient carePharmacy clinicObservational studyInclusion criteriaUse disordersPeer-reviewed studies
2023
PET Biomarkers in Psychiatry
Orhii P, Radhakrishnan R, Selvaraj S. PET Biomarkers in Psychiatry. 2023, 81-104. DOI: 10.1007/978-3-031-43356-6_6.Peer-Reviewed Original ResearchThe regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSynaptic densityAge-related decreaseMagnetic resonance imagingBlood flowAge-related synaptic lossGray matter volume lossSynaptic density lossPositron emission tomography (PET) ligandSynaptic vesicle glycoprotein 2AVivo PET measurementsMedial occipital cortexGray matter volumeAge-related neurodegenerationGray matter regionsCognitive normal subjectsAge-related changesSynaptic lossNerve terminalsWide age rangeOccipital cortexTomography ligandNormal subjectsGM volumeAge-related functional lossesMatter volumeSubstance Use Disorder and Health Outcomes in COVID-19—The Need for a Better Research Method to Determine Substance Use Exposure
Christian N, Zhou X, Radhakrishnan R. Substance Use Disorder and Health Outcomes in COVID-19—The Need for a Better Research Method to Determine Substance Use Exposure. JAMA Psychiatry 2023, 80: 968-968. PMID: 37405794, DOI: 10.1001/jamapsychiatry.2023.2113.Peer-Reviewed Original ResearchCitationsA leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Jauhar S, Arnone D, Baldwin D, Bloomfield M, Browning M, Cleare A, Corlett P, Deakin J, Erritzoe D, Fu C, Fusar-Poli P, Goodwin G, Hayes J, Howard R, Howes O, Juruena M, Lam R, Lawrie S, McAllister-Williams H, Marwaha S, Matuskey D, McCutcheon R, Nutt D, Pariante C, Pillinger T, Radhakrishnan R, Rucker J, Selvaraj S, Stokes P, Upthegrove R, Yalin N, Yatham L, Young A, Zahn R, Cowen P. A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression. Molecular Psychiatry 2023, 28: 3149-3152. PMID: 37322065, PMCID: PMC10618084, DOI: 10.1038/s41380-023-02095-y.Peer-Reviewed Original ResearchCitationsAltmetricImpact of personal beliefs about medical cannabis on physician recommendation practices: Results of an international survey
Syed S, Singh J, Elkholy H, Rojnić Palavra I, Tomicevic M, Eric A, Pinto da Costa M, Guloksuz S, Radhakrishnan R. Impact of personal beliefs about medical cannabis on physician recommendation practices: Results of an international survey. Asian Journal Of Psychiatry 2023, 85: 103634. PMID: 37257363, DOI: 10.1016/j.ajp.2023.103634.Peer-Reviewed Original ResearchCitationsAltmetricRole of Psychedelics in Treatment-Resistant Depression
Kamal S, Jha M, Radhakrishnan R. Role of Psychedelics in Treatment-Resistant Depression. Psychiatric Clinics Of North America 2023, 46: 291-305. PMID: 37149346, DOI: 10.1016/j.psc.2023.02.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
Clinical Trials
Current Trials
M1 Schizophrenia PET Study
HIC ID2000031171RolePrincipal InvestigatorPrimary Completion Date04/30/2023Recruiting ParticipantsGenderBothAge18 years - 55 yearsImaging cortisol metabolism in liver, adipose tissue and brain with a novel PET radioligand
HIC ID2000029576RoleSub InvestigatorPrimary Completion Date06/30/2024Recruiting ParticipantsSchizophrenia Spectrum Biomarkers Consortium (SSBC)
HIC ID2000029485RoleSub InvestigatorPrimary Completion Date12/31/2030Recruiting ParticipantsTesting a Computationally-Informed, Personalized Intervention for Hallucinations
HIC ID2000024774RoleSub InvestigatorPrimary Completion Date03/31/2024Recruiting ParticipantsGenderBothAge18 years - 65 yearsA longitudinal study of the effects of cannabis exposure on neuro-development in adolescents and young adults
HIC ID2000024543RoleSub InvestigatorPrimary Completion Date01/31/2021Recruiting ParticipantsGenderBothAge13 years - 25 years
Academic Achievements & Community Involvement
Activities
activity American Society of Clinical Psychopharmacology (ASCP)
05/01/2017 - PresentProfessional OrganizationsCommittee Memberactivity Schizophrenia International Research Society (SIRS)
07/31/2019 - PresentProfessional OrganizationsCommittee Memberactivity Journal of Dual Diagnosis
09/11/2019 - PresentJournal ServiceAssociate Editoractivity Yale University Human Investigation Committee (HIC)
09/01/2016 - PresentCommitteesMemberactivity Medical Research Council (MRC), UK
2019 - PresentPeer Review Groups and Grant Study SectionsAd-hoc reviewer
Honors
honor NIH Early Career Reviewer
10/07/2020National AwardNIH CSRDetailsUnited Stateshonor 2020 CPDD Travel Award for Early Career Investigators
05/12/2020International AwardCollege on Problems of Drug Dependence (CPDD)DetailsUnited Stateshonor ISCTM 2020 New Investigator Award
12/20/2019International AwardInternational Society for CNS Clinical Trials Methodology (ISCTM)DetailsUnited Stateshonor Alavi-Mandell Award
04/16/2019International AwardSociety for Nuclear Medicine and Molecular Imaging (SNMMI)DetailsUnited Stateshonor American College of Neuropsychopharmacology Travel Award 2018
06/30/2018International AwardDetailsUnited States
News
News
- December 13, 2024
Five Faculty Elected to Associate Membership of ACNP
- October 02, 2024
Bipolar Disorder Patients Respond to Ketamine, Esketamine Treatment
- April 02, 2024Source: Molecular Psychiatry
Substance Use and Spine Density: A Systematic Review and Meta-Analysis of Preclinical Studies
- December 18, 2022
Radhakrishnan Named Co-Medical Director of Yale PET Center