Zhouqi Meng
Associate Research ScientistCards
About
Research
Publications
2025
Signal Transducer Nanoparticles Enable Siglec‐10/G Blockade Immunotherapy for Breast Cancer Treatment
Meng Z, Gao X, Tang X, Fan J, Sheu W, Tu Z, Yu J, Long G, Wang L, Liu R, Zhou J. Signal Transducer Nanoparticles Enable Siglec‐10/G Blockade Immunotherapy for Breast Cancer Treatment. Advanced Materials 2025, 37: e2502758. PMID: 40619860, DOI: 10.1002/adma.202502758.Peer-Reviewed Original ResearchImmune checkpoint blockadeBreast cancerNext generation of cancer immunotherapiesTriple-negative BCHigher recurrence rateInhibited tumor growthBreast cancer treatmentBlockade immunotherapyCheckpoint blockadeCancer immunotherapyLow side effectsCombination therapyRecurrence rateRRx-001Immune cellsTumor growthDrug resistanceSmall molecule inhibitorsCurrent treatmentImmune responseSide effectsTherapeutic effectCancer treatmentEnhanced phagocytosisBC cellsPhosphatidylcholine-derived carriers facilitate brain tumor delivery and enhance glioblastoma therapy
Yu J, Tu Z, Fan J, Lei K, Meng Z, Chen B, Wang Z, Escobar W, Zhou J. Phosphatidylcholine-derived carriers facilitate brain tumor delivery and enhance glioblastoma therapy. Journal Of Controlled Release 2025, 385: 113999. PMID: 40617515, PMCID: PMC12302413, DOI: 10.1016/j.jconrel.2025.113999.Peer-Reviewed Original ResearchConceptsTreatment of glioblastomaBlood-brain barrierBrain tumorsEffective treatmentDrug delivery to brain tumorsIneffective treatmentDrug delivery to tumorsBrain tumor deliveryEffective treatment of glioblastomaDelivery to tumorsDelivery of therapeutic agentsBrain tumor biologyCathepsin B cleavable linkerTumor deliveryTumor biologyLysophosphatidylcholine transporterGlioblastoma therapyTumorGlioblastomaTherapeutic payloadsTherapeutic agentsBrain cancerBrainLysophosphatidylcholineDrugA lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Chen X, Tang X, Xie Y, Cuffari B, Tang C, Cao F, Gao X, Meng Z, Noble P, Young M, Turk O, Shirali A, Gera J, Nishimura R, Zhou J, Hansen J. A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells. Science Signaling 2025, 18: eadk3320-eadk3320. PMID: 40132052, PMCID: PMC12076517, DOI: 10.1126/scisignal.adk3320.Peer-Reviewed Original ResearchThis study investigates a lupus-derived autoantibody's ability to activate tumor immunity via intracellular RNA-binding and cGAS activation, improving glioblastoma survival and enabling RNA delivery into cells.
2022
Fast Fourier Transform-weighted Photoacoustic Imaging by In Vivo Magnetic Alignment of Hybrid Nanorods
Li Z, Meng Z, Tian F, Ye Z, Zhou X, Zhong X, Chen Q, Yang M, Liu Z, Yin Y. Fast Fourier Transform-weighted Photoacoustic Imaging by In Vivo Magnetic Alignment of Hybrid Nanorods. Nano Letters 2022, 22: 5158-5166. PMID: 35762802, DOI: 10.1021/acs.nanolett.2c00854.Peer-Reviewed Original ResearchConceptsMagnetic alignmentPhoton-phonon conversionMagnetic fieldField directionPA signalHybrid nanorodsPA imaging techniqueFast Fourier transformHigh-resolution tomographyPA imagingPeriodic changesImage qualityImaging sensitivityActivity modulationComputational algorithmBackground noisePixel subtractionFourier transformFrequency domainPhotoacousticsNanovaccines with cell-derived components for cancer immunotherapy
Meng Z, Zhang Y, Zhou X, Ji J, Liu Z. Nanovaccines with cell-derived components for cancer immunotherapy. Advanced Drug Delivery Reviews 2022, 182: 114107. PMID: 34995678, DOI: 10.1016/j.addr.2021.114107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCancer nanovaccinesCancer immunotherapyCell-derived componentsBiomimetic nanovaccinesTumor-specific immunological responsesTumor-associated antigensAntitumor immunityCell-derived nanovesiclesImmunotherapeutic approachesAttack tumorsImmunotherapy responseVaccine platformNanovaccineImmune responseImmunological responseClinical translationCancerImmunotherapyCell membraneReview articleCell lysatesCellsTumorExogenous materialsAntigen
2021
Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief
Zhang R, Cheng L, Dong Z, Hou L, Zhang S, Meng Z, Betzer O, Wang Y, Popovtzer R, Liu Z. Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief. Materials Horizons 2021, 8: 1314-1322. PMID: 34821924, DOI: 10.1039/d0mh00193g.Peer-Reviewed Original ResearchUltrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy
Meng Z, Zhang Y, She J, Zhou X, Xu J, Han X, Wang C, Zhu M, Liu Z. Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy. Nano Letters 2021, 21: 1228-1237. PMID: 33522825, DOI: 10.1021/acs.nanolett.0c03646.Peer-Reviewed Original ResearchConceptsIndividualized cancer immunotherapyCancer immunotherapySubcutaneous injectionPostoperative tumor metastasisImmune checkpoint blockadeAntitumor immune responseOptimal vaccine effectivenessDelivery of vaccinesCheckpoint blockadeInjection of vaccineTumor vaccinesTumor metastasisImmune responsePatient comfortVaccine effectivenessNanovaccineResponse to ultrasound treatmentImmunotherapyVaccine releaseVaccineBurst releaseTumorUltrasound-mediatedDiseaseTreatment
2020
Thermo‐Triggered In Situ Chitosan‐Based Gelation System for Repeated and Enhanced Sonodynamic Therapy Post a Single Injection
She J, Zhou X, Zhang Y, Zhang R, Li Q, Zhu W, Meng Z, Liu Z. Thermo‐Triggered In Situ Chitosan‐Based Gelation System for Repeated and Enhanced Sonodynamic Therapy Post a Single Injection. Advanced Healthcare Materials 2020, 10: e2001208. PMID: 33236504, DOI: 10.1002/adhm.202001208.Peer-Reviewed Original ResearchConceptsEfficacy of sonodynamic therapySonodynamic therapySolid tumorsReactive oxygen speciesDecomposition of endogenous H2 O2Single dose injectionOptimal therapeutic responseDeep-seated tumorsTherapeutic responseRobust treatment effectsDose injectionGeneration of reactive oxygen speciesPatient incomplianceTumorSide effectsEndogenous H2 O2Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy
Zhou X, Meng Z, She J, Zhang Y, Yi X, Zhou H, Zhong J, Dong Z, Han X, Chen M, Fan Q, Yang K, Wang C. Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy. Nano-Micro Letters 2020, 12: 100. PMID: 34138094, PMCID: PMC7770715, DOI: 10.1007/s40820-020-00431-3.Peer-Reviewed Original ResearchImmune checkpoint blockade therapyAnti-PD-L1Checkpoint blockade therapyImmunosuppressive tumor microenvironmentDelivery platformBlockade therapyNO delivery systemsRadiotherapy effectTumor microenvironmentTumor growthNO delivery platformDelivery systemRadiotherapyRadioimmunotherapyTumorTherapyMicroenvironment
2019
Renal Clearable Ru-based Coordination Polymer Nanodots for Photoacoustic Imaging Guided Cancer Therapy
Zhang R, Fan X, Meng Z, Lin H, Jin Q, Gong F, Dong Z, Li Y, Chen Q, Liu Z, Cheng L. Renal Clearable Ru-based Coordination Polymer Nanodots for Photoacoustic Imaging Guided Cancer Therapy. Theranostics 2019, 9: 8266-8276. PMID: 31754395, PMCID: PMC6857064, DOI: 10.7150/thno.36986.Peer-Reviewed Original ResearchConceptsLong-term toxicityImaging-guided photothermal therapyPolymer nanodotsConversion efficiencyRenal excretionCancer therapyPhotothermal conversion efficiencyPhotothermal therapyImaging-guided cancer therapyRuthenium ionsImaging guided cancer therapyCancer treatment efficiencyChronic retentionRenal clearanceTumor retentionSystemic administrationEfficient tumor retentionTherapyEfficient renal clearanceHigh photothermal conversion efficiencyPhotothermal conversionClinical applicationTheranostic nanoagentsPhotothermal agentsNanodots
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