Ralph Horwitz, MD
Professor Emeritus of Medicine (General Medicine)Cards
About
Research
Publications
2026
The Patient the Trial Cannot See: Clinical Reasoning and Mechanism in the Age of Precision Medicine
Horwitz R, Conroy A, Cullen M, Sim I. The Patient the Trial Cannot See: Clinical Reasoning and Mechanism in the Age of Precision Medicine. The American Journal Of Medicine 2026 PMID: 42167567, DOI: 10.1016/j.amjmed.2026.05.008.Peer-Reviewed Original ResearchEvidence-based medicineMechanistic reasoningClinical reasoningEpistemological standScientific prestigeContemporary medicineMolecular biologyExplicit goalsIndividual patient careReasonsIndividualized carePatient carePopulation evidenceMedical educationClinical practiceTraditionCareArgumentsClinical medicineAge of precision medicineClinical culturesMedicineIndividual patientsInstitutional supportInstitutionalizationBiography Inscribed in Biology: The Diagnostic Criteria for Psychosomatic Research and the Embodiment of Lived Experience.
Horwitz R. Biography Inscribed in Biology: The Diagnostic Criteria for Psychosomatic Research and the Embodiment of Lived Experience. The Journal Of Clinical Psychiatry 2026, 87 PMID: 41920003, DOI: 10.4088/jcp.26com16386.Peer-Reviewed Original ResearchThe health consequences of politically-induced trauma
Horwitz R. The health consequences of politically-induced trauma. PLOS Mental Health 2026, 3: e0000579. PMID: 41860841, PMCID: PMC13004349, DOI: 10.1371/journal.pmen.0000579.Peer-Reviewed Original ResearchBiography is the dark matter of disease pathogenesis
Horwitz R, Conroy A, Cullen M, Sim I. Biography is the dark matter of disease pathogenesis. The American Journal Of Medicine 2026, 139: 848-853. PMID: 41687948, DOI: 10.1016/j.amjmed.2026.01.045.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBiography as the dark matter of treatment response
Horwitz R, Conroy A, Cullen M, Sim I. Biography as the dark matter of treatment response. The American Journal Of Medicine 2026, 139: 702-707. PMID: 41666970, DOI: 10.1016/j.amjmed.2026.01.044.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe Person–Population Paradox in Clinical Medicine
Horwitz R, Conroy A, Cullen M, Sim I. The Person–Population Paradox in Clinical Medicine. The American Journal Of Medicine 2026 PMID: 41666972, DOI: 10.1016/j.amjmed.2026.01.047.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsReconceptualizing obesity and the modern definition of disease
Horwitz R, Hayes Conroy A, Cullen M, Sim I. Reconceptualizing obesity and the modern definition of disease. The American Journal Of Medicine 2026, 139: 967-971. PMID: 41662898, DOI: 10.1016/j.amjmed.2026.01.052.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
The imperative of the person in personalized medicine
Horwitz R, Conroy A, Cullen M, Matory A, Singer B, Sim I. The imperative of the person in personalized medicine. Communications Medicine 2025, 5: 469. PMID: 41238826, PMCID: PMC12618932, DOI: 10.1038/s43856-025-01218-6.Peer-Reviewed Original ResearchBiosocial Variation in Treatment Response to GLP-1s: Implications for Clinical Care and Health Policy
Horwitz R, Otaka S, Conroy A, Cullen M, Matory A, Singer B, Sim I. Biosocial Variation in Treatment Response to GLP-1s: Implications for Clinical Care and Health Policy. The American Journal Of Medicine 2025, 138: 1346-1351. PMID: 40393609, DOI: 10.1016/j.amjmed.2025.05.016.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTreatment-resistant obesityTrajectory of obesityResponse to treatmentObesity-related disordersRandomized Controlled TrialsReal-world evidence studiesTreatment responseClinical managementEvidence studiesGLP-1sControlled TrialsPatientsObesityWeight lossBody weightPathogenesisAverage treatment responseHealth policyTreatmentPhysiological systems
2024
Integrating biology and biography in medicine: The mind and body are not separate
Horwitz R, Cullen M, Conroy A, Sim I, Singer B, Badal K, Offidani E. Integrating biology and biography in medicine: The mind and body are not separate. PLOS Mental Health 2024, 1: e0000122. PMID: 41661880, PMCID: PMC12798616, DOI: 10.1371/journal.pmen.0000122.Peer-Reviewed Original Research
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