Jeff Coleman, PhD
Research Associate Cell BiologyCards
About
Research
Publications
2026
Turbocharging synaptic transmission: 12 SNAREpins are required for rapid release of reconstituted synaptic vesicles
Bera M, Chatterjee A, Aji A, Sundaram R, Coleman J, Maroofian R, Salpietro V, Radhakrishnan A, Gautam S, Grushin K, Caruel M, Houlden H, Gupta K, Ramakrishnan S, Pincet F, Rothman J. Turbocharging synaptic transmission: 12 SNAREpins are required for rapid release of reconstituted synaptic vesicles. Science Advances 2026, 12: eaea0592. PMID: 42384787, PMCID: PMC13322239, DOI: 10.1126/sciadv.aea0592.Peer-Reviewed Original ResearchMolecular Flexibility and Electrostatic Interactions Drive the Nanoscale Structure of Coiled-Coil GM130 Protein Condensates
Mateos-Gil P, Feito A, Cava D, Tejedor A, Almendro-Vedia V, Coleman J, Zheng H, Simanjuntak M, Goder J, Rothman J, Espinosa J, Pincet F, López-Montero I. Molecular Flexibility and Electrostatic Interactions Drive the Nanoscale Structure of Coiled-Coil GM130 Protein Condensates. PRX Life 2026, 4: 023021. DOI: 10.1103/lp87-svtc.Peer-Reviewed Original ResearchSynaptic transmission: Munc13 assembles onto PI(4,5)P2-rich domains into trimers that cooperate to capture vesicles
Li F, Radhakrishnan A, Gautam S, Diaz G, Sundaram R, Coleman J, Zheng H, Grushin K, Chavent M, Rothman J, Pincet F. Synaptic transmission: Munc13 assembles onto PI(4,5)P2-rich domains into trimers that cooperate to capture vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2523347123. PMID: 41671179, PMCID: PMC12912961, DOI: 10.1073/pnas.2523347123.Peer-Reviewed Original Research
2025
Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
Bera M, Grushin K, Kalyana Sundaram R, Hinzen J, Chen J, Chatterjee A, Radhakrishnan A, Lee S, Padmanarayana M, Coleman J, Pincet F, Rothman J, Dittman J. Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release. Nature Communications 2025, 16: 7222. PMID: 40764329, PMCID: PMC12325603, DOI: 10.1038/s41467-025-62420-7.Peer-Reviewed Original ResearchHighly stable planar asymmetric suspended membranes for investigating protein dynamics and membrane fusion
Bera M, Kalyana Sundaram R, Coleman J, Chatterjee A, Thoduvayil S, Pincet F, Ramakrishnan S. Highly stable planar asymmetric suspended membranes for investigating protein dynamics and membrane fusion. Nature Protocols 2025, 20: 3582-3606. PMID: 40461798, DOI: 10.1038/s41596-025-01192-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLithium fine tunes lipid membranes through phospholipid binding
Bunel L, Adrien V, Coleman J, Heo P, Pincet F. Lithium fine tunes lipid membranes through phospholipid binding. Scientific Reports 2025, 15: 13366. PMID: 40246965, PMCID: PMC12006515, DOI: 10.1038/s41598-025-97828-0.Peer-Reviewed Original Research
2024
Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers
Li F, Coleman J, Redondo-Morata L, Kalyana Sundaram R, Stroeva E, Rothman J, Pincet F. Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers. Communications Biology 2024, 7: 1608. PMID: 39627539, PMCID: PMC11615320, DOI: 10.1038/s42003-024-07317-9.Peer-Reviewed Original ResearchA proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs
Brown C, Ghosh S, McAllister R, Kumar M, Walker G, Sun E, Aman T, Kumar S, Li W, Coleman J, Liu Y, Rothman J, Bhattacharyya M, Gupta K. A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs. Nature Methods 2024, 22: 412-421. PMID: 39609567, PMCID: PMC11810782, DOI: 10.1038/s41592-024-02517-x.Peer-Reviewed Original Research
2023
Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle
Bera M, Radhakrishnan A, Coleman J, Sundaram R, Ramakrishnan S, Pincet F, Rothman J. Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2311484120. PMID: 37903271, PMCID: PMC10636311, DOI: 10.1073/pnas.2311484120.Peer-Reviewed Original ResearchDiacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles
Li F, Grushin K, Coleman J, Pincet F, Rothman J. Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306086120. PMID: 37883433, PMCID: PMC10623011, DOI: 10.1073/pnas.2306086120.Peer-Reviewed Original Research