Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsAurélien Justet
Assistant Professor AdjunctAbout
Research
Publications
2026
The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis
Ruwisch J, Cazes A, Leiber L, Borie R, Neubert L, Christian L, de Montpréville V, Szmul A, Moussa F, Verleden S, Gaedcke S, Hegermann J, Fuge J, Ballmaier M, Kamp J, Greer M, Braubach P, Werlein C, Ius F, Graalmann T, Aburahma K, De Sadeleer L, Egashira R, Ackermann M, Yamada D, Hoeper M, Falk C, Gottlieb J, Schiller H, Vanaudenaerde B, Seeliger B, Debray M, Bernaudin J, Knudsen L, Bergot E, Jacob J, Mal H, Jonigk D, Dettmer S, Mordant P, Prasse A, Fadel E, Wuyts W, Crestani B, Kaminski N, Justet A, Schupp J. The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis. Science Advances 2026, 12: eaeb5967. PMID: 42102198, PMCID: PMC13162212, DOI: 10.1126/sciadv.aeb5967.Peer-Reviewed Original ResearchConceptsInterstitial lung diseasePleuroparenchymal fibroelastosisProgressive interstitial lung diseaseCellular landscapeTertiary lymphoid structuresAberrant cell statesIdiopathic pulmonary fibrosisRNA in situ hybridizationIntra-alveolar fibrosisCellular disease processesCellular machineryLymphoid structuresSeptal elastosisImmune cellsPulmonary fibrosisBasaloid cellsFibrotic remodelingLung fibrosisInflammatory microenvironmentLung diseaseCell statesTherapeutic strategiesCollagen depositionMolecular rationaleFibrosisD18-09 The Multiorgan Multicenter Spatial Transcriptomics Atlas Reveals Layered Granuloma Architecture and Cellular Programs Driving Sarcoidosis
Ruwisch J, Christian L, Traidl S, Dietrich J, Kamp J, Casper J, Giercke L, Seeliger B, Ius F, Greer M, Werlein C, Gottlieb J, Hoeper M, Justet A, Falk C, Li Y, Teichmann S, Kaminski N, Jeny F, Schmidt-Ott K, Schacht V, Schefzyk M, Jonigk D, Neubert L, Schupp J. D18-09 The Multiorgan Multicenter Spatial Transcriptomics Atlas Reveals Layered Granuloma Architecture and Cellular Programs Driving Sarcoidosis. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2835. DOI: 10.1093/ajrccm/aamag162.2835.Peer-Reviewed Original ResearchMultinucleated giant cellsGranuloma biologySarcoidosis granulomasGiant cellsMultiplex immunofluorescence stainingImmune cell aggregatesGranuloma architectureTranscriptional programsCellular blueprintLigand-receptor analysisSarcoidosis diagnosisStromal zonesMonocyte stateTissue-specific programsLymph nodesMyeloid cellsBone marrowStress adaptation pathwaysMacrophage programmingPulmonary granulomasSarcoidosisInflammatory fibroblastsInflammatory diseasesTherapeutic strategiesOrgan-specific featuresPrecision-cut lung slices as a model to study Radiation-Induced genome instability and Pulmonary Fibrogenesis
Moussa F, de Montpreville V, Blanchard I, Anfray C, Toutain J, Bernaudin J, Fadel E, Bernaudin M, Valable S, Bergot E, Justet A. Precision-cut lung slices as a model to study Radiation-Induced genome instability and Pulmonary Fibrogenesis. Revue Des Maladies Respiratoires 2026, 43: 26-27. DOI: 10.1016/j.rmr.2025.12.049.Peer-Reviewed Original ResearchPrecision-cut lung slicesMouse precision-cut lung slicesDay 5Positive cellsGenomic instabilityLung slicesRadiation doseProportion of positive cellsMarie Lannelongue HospitalHuman precision-cut lung slicesRadiation-induced genomic instabilityFresh human lung tissueIdiopathic pulmonary fibrosisExpression of fibrosis-related genesDNA damageRadiation-induced DNA damageDose-response studyHigh radiation dosesSingle-nucleus sequencingDNA damage-associated genesFibrosis-related genesSomatic mutation rateHuman lung tissuePreliminary dataC57BL/6 micePrognostic factors in interstitial lung disease-associated pulmonary hypertension: data from the HYPID cohort and the French Pulmonary Hypertension Registry.
Diesler R, Turquier S, Reynaud-Gaubert M, Lestelle F, Lacoste-Palasset T, Valentin V, Quétant S, Chaouat A, Boissin C, Noël-Savina É, Tromeur C, Justet A, Maurac A, Artaud-Macari É, Nunes H, Bertoletti L, Magro P, Horeau-Langlard D, Seronde M, Favrolt N, Trésorier R, Lamia B, Chabanne C, Riou M, Renard S, Sanchez O, Gagnadoux F, Nieves A, Ahmad K, Traclet J, Sitbon O, Lamblin N, Degano B, Valentin S, Bourdin A, Humbert M, Boucly A, Subtil F, Montani D, Cottin V. Prognostic factors in interstitial lung disease-associated pulmonary hypertension: data from the HYPID cohort and the French Pulmonary Hypertension Registry. European Respiratory Journal 2026, 2502233. PMID: 41887671, DOI: 10.1183/13993003.02233-2025.Peer-Reviewed Original ResearchInterstitial lung diseasePulmonary Hypertension RegistryILD-PHPH therapyPulmonary hypertensionPrognostic factorsWood unitsHypertension RegistryPulmonary fibrosisFrench Pulmonary Hypertension RegistryMean pulmonary vascular resistanceMultivariate analysisTransplant-free survival timePrognostic factors of patientsUnclassifiable interstitial lung diseaseMean pulmonary artery pressurePredictor of 1-year mortalityInterstitial lung disease diagnosisFibrotic hypersensitivity pneumonitisFunctional class IIIPulmonary vascular resistanceCombined pulmonary fibrosisPulmonary artery pressureIdiopathic pulmonary fibrosisAssociated with prognosisLung cysts, a common feature found in patients with hairy cell leukaemia and Langerhans cell histiocytosis
Haegy J, Maitre E, Justet A, Morello R, Domagne J, Rivière F, Damaj G, Troussard X, Bergot E. Lung cysts, a common feature found in patients with hairy cell leukaemia and Langerhans cell histiocytosis. ERJ Open Research 2026, 12: 01172-2025. PMID: 42267379, PMCID: PMC13244211, DOI: 10.1183/23120541.01172-2025.Peer-Reviewed Original ResearchProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arterySmooth muscle cellsPerivascular macrophagesMouse modelMuscle cellsRight ventricle functionMedial smooth muscle cellsPulmonary arterial stiffeningRight ventricleVentricle functionAssociated with senescenceECM turnoverLung functionArterial stiffeningArteryAdventitial fibroblastsMolecular targetsAge-relatedGeroscience hypothesisLungAgeIntercellular signalingMiceMacrophages
2025
From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis
Justet A, Schupp J. From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis. European Respiratory Journal 2025, 66: 2501466. PMID: 41057218, DOI: 10.1183/13993003.01466-2025.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisExtracellular matrix componentsPulmonary fibrosisExcessive deposition of extracellular matrix componentsIdiopathic interstitial lung diseaseDeposition of extracellular matrix componentsPathological wound-healing responsePotential therapeutic targetExcessive depositionInterstitial lung diseaseCellular targetsImpaired gas exchangeWound healing responseGas exchangeMatrix componentsTherapeutic targetRespiratory failureCell populationsLung diseaseFatal disorderMouse modelSevere formLung parenchymaIrreversible remodelingFibrosisLung cysts, a common feature found in patients with hairy cell leukemia and Langerhans cell histiocytosis suggesting a potential implication of MAPK-pathway genetic alteration
Haegy J, Maitre E, Justet A, Morello R, Domagne J, Riviere F, Damaj G, Troussard X, Bergot E. Lung cysts, a common feature found in patients with hairy cell leukemia and Langerhans cell histiocytosis suggesting a potential implication of MAPK-pathway genetic alteration. 2025, pa894. DOI: 10.1183/13993003.congress-2025.pa894.Peer-Reviewed Original ResearchInhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models
Wagner D, Alsafadi H, Mitash N, Justet A, Hu Q, Pineda R, Staab-Weijnitz C, Korfei M, Gvazava N, Wannemo K, Onwuka U, Mozurak M, Estrada-Bernal A, Cala-Garcia J, Mutze K, Costa R, Bölükbas D, Stegmayr J, Skronska-Wasek W, Klee S, Ota C, Baarsma H, Wang J, Sembrat J, Hilgendorff A, Ding J, Günther A, Chambers R, Rosas I, de Langhe S, Kaminski N, Lehmann M, Eickelberg O, Königshoff M. Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models. Nature Communications 2025, 16: 7099. PMID: 40753090, PMCID: PMC12318044, DOI: 10.1038/s41467-025-61795-x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlveolar Epithelial CellsAnimalsCell Cycle ProteinsDisease Models, AnimalDNA-Binding ProteinsExtracellular MatrixFemaleHumansIdiopathic Pulmonary FibrosisLungMaleMiceMice, Inbred C57BLProtein-Lysine 6-OxidaseSignal TransductionTranscription FactorsVerteporfinYAP-Signaling ProteinsConceptsIdiopathic pulmonary fibrosisAlveolar typePulmonary fibrosisIdiopathic pulmonary fibrosis patientsAlveolar type II cellsFibrosis in vivoLung fibrosis in vivoExcessive extracellular matrix depositionType II cellsExcessive extracellular matrix productionPreclinical modelsExtracellular matrix depositionDisease progressionPotential therapiesTissue ex vivoYAP inhibitionCrosslinking of extracellular matrixII cellsLethal diseaseExtracellular matrix productionActive YAPFibrosisMatrix depositionInhibitionDiseaseA deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 9: 2155-2180. PMID: 40542107, PMCID: PMC12705450, DOI: 10.1038/s41551-025-01423-7.Peer-Reviewed Original ResearchComplex cellular dynamicsCellular dynamicsSingle-cell transcriptomic dataIn silico drug discoverySingle-cell transcriptomicsTranscriptome dataPotential therapeutic drug candidateComplex diseasesHuman diseasesIdiopathic pulmonary fibrosisTherapeutic drug candidateCell embeddingDrug discoveryPulmonary fibrosisDrug candidatesDisease progressionHuman tissuesHuman precision-cut lung slicesDynamic analysisPrecision-cut lung slicesPathological landscapeComputational toolsAnti-fibrotic effectsUnagiTranscriptome