Aseem Vashist, MD
Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2026
Blunted Heart Rate Response to Regadenoson Predicts Cardiovascular Risk Beyond Quantitative PET Myocardial Blood Flow
Barreto J, Vashist A, Gallegos Kattan C, Stendahl J, Sadeghi M, Sposito A, Miller E, Sinusas A, Feher A, Moura F. Blunted Heart Rate Response to Regadenoson Predicts Cardiovascular Risk Beyond Quantitative PET Myocardial Blood Flow. Journal Of Nuclear Cardiology 2026, 102766. PMID: 42190937, DOI: 10.1016/j.nuclcard.2026.102766.Peer-Reviewed Original ResearchStress myocardial blood flowBlunted heart rate responseIncremental prognostic valueMyocardial flow reserveArea under the receiver-operating characteristic curveHeart rate responsePrognostic valueNet reclassification indexMyocardial blood flowNormal heart rate responseAdenosine A2A receptor agonistA2A receptor agonistReceiver-operating characteristic curveAssociated with higher CV riskBlood flowMedian Follow-UpHigh CV riskMultivariate Cox regressionPredicting cardiovascular riskRate responsePET/CT studiesPrognostic discriminationReceptor agonistsAutonomic dysfunctionClinical characteristicsPatients’ pain experience in claudication: Biopsychosocial correlates of frequency, intensity, sleep interference, and chronic pain
Romain G, Alashi A, Tapia C, Sinusas A, Galiana G, Barry D, Vashist A, Lang E, Garland E, Mena-Hurtado C, Smolderen K. Patients’ pain experience in claudication: Biopsychosocial correlates of frequency, intensity, sleep interference, and chronic pain. Journal Of Pain 2026, 46: 106320. PMID: 42173296, DOI: 10.1016/j.jpain.2026.106320.Peer-Reviewed Original ResearchResting ankle-brachial indexAnkle-brachial indexPatients' pain experiencePeripheral arterial diseaseDepressive symptomsPeripheral arterial disease severityBiopsychosocial correlatesPsychological factorsPeripheral artery disease careChronic painIntegrated care strategiesHierarchical logistic regression modelsPeripheral Artery QuestionnaireRutherford stageLogistic regression modelsHemodynamic measurementsArtery diseaseStage of peripheral arterial diseaseCare strategiesPain correlationPsychological distressMental healthBiopsychosocial assessmentPerceived stressPain characteristics26-A-10988-ACC BLUNTED HEART RATE RESPONSE TO REGADENOSON IS ASSOCIATED WITH HIGH RISK BEYOND PET QUANTITATIVE MYOCARDIAL BLOOD FLOW
Oliveira J, Kattan C, Vashist A, Stendahl J, Sadeghi M, Sposito A, Miller E, Sinusas A, Feher A, Moura F. 26-A-10988-ACC BLUNTED HEART RATE RESPONSE TO REGADENOSON IS ASSOCIATED WITH HIGH RISK BEYOND PET QUANTITATIVE MYOCARDIAL BLOOD FLOW. Journal Of The American College Of Cardiology 2026, 87: a936-a937. DOI: 10.1016/j.jacc.2026.02.2307.Peer-Reviewed Original ResearchLow-Dose CT as a Diagnostic Clue: Unmasking Anemia as a Cause of Reduced Myocardial Flow Reserve on PET/CT
Ambrosini A, Vashist A, Sinusas A, Moura F. Low-Dose CT as a Diagnostic Clue: Unmasking Anemia as a Cause of Reduced Myocardial Flow Reserve on PET/CT. Journal Of Nuclear Cardiology 2026, 102646. PMID: 41580018, DOI: 10.1016/j.nuclcard.2026.102646.Peer-Reviewed Original ResearchThis case investigates how low-dose CT imaging can identify anemia as a cause of reduced myocardial flow reserve, aiding accurate diagnosis and preventing misclassification of coronary conditions.Biopsychosocial predictors of long-term major amputation following peripheral vascular intervention in chronic limb-threatening ischemia using a machine learning algorithm approach
Joodi G, Romain G, Cleman J, Rendon I, Tabet R, Scierka L, Rahman M, Vashist A, Mubarak E, Tapia C, Smolderen K, Mena-Hurtado C. Biopsychosocial predictors of long-term major amputation following peripheral vascular intervention in chronic limb-threatening ischemia using a machine learning algorithm approach. JVS-Vascular Insights 2026, 4: 100348. DOI: 10.1016/j.jvsvi.2025.100348.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAmputation riskPeripheral vascular interventionsBiopsychosocial factorsBiopsychosocial predictorsMajor amputationLimb-threatening ischemiaRisk factorsDelivery of individualized careHigh riskCardiovascular risk factorsBelow-the-kneeIndividualized careLimb outcomesClinical risk factorsFunctional statusVascular interventionsMultidisciplinary involvementBehavioral factorsAmputationQuality InitiativeFemale sexPre-procedural variablesPatient characteristicsOutcome data
2025
Imaging practices following peripheral vascular intervention in chronic limb-threatening ischemia and association with amputation outcomes
Smolderen K, Rahman M, Romain G, Scierka L, Cleman J, Knight D, Vashist A, Mena-Hurtado C. Imaging practices following peripheral vascular intervention in chronic limb-threatening ischemia and association with amputation outcomes. Vascular Medicine 2025, 31: 35-46. PMID: 41395888, DOI: 10.1177/1358863x251379799.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaMedian odds ratioIntraclass correlation coefficientPeripheral vascular interventionsAmputation outcomesLimb-threatening ischemiaAmputation rateResults:Access to careImaging practicesHigher amputation rateImaging testsMajor amputationHigher RatesOdds ratioMethods:Significant site variablesVascular interventionsAmputationSymptom statusFollow-up imaging protocolsVascular Quality Initiative dataPropensity-matched cohortInterventionCorrelation coefficientPeriprocedural outcomes of embolic protection device use in carotid artery stenting
Callegari S, Romain G, Balasquide Odeh O, Tapia C, Pinto D, Rahman M, Vashist A, Smolderen K, Mena-Hurtado C. Periprocedural outcomes of embolic protection device use in carotid artery stenting. Journal Of Vascular Surgery 2025, 83: 738-746.e3. PMID: 41077289, DOI: 10.1016/j.jvs.2025.10.004.Peer-Reviewed Original ResearchCarotid artery stentingEmbolic protection devicesIn-Hospital MortalityNational quality improvement effortsPeriprocedural outcomesAssociated with higher oddsCumulative incidenceQuality improvement effortsArtery stentingCox proportional hazards regressionAssociated with higher in-hospitalAssociated with lower mortalityEPD groupHigher in-hospitalVascular Quality Initiative registryRisk of deathCarotid artery stenosisHigher oddsManagement of carotid artery stenosisMortality outcomesImprovement effortsTranscarotid artery revascularizationPropensity score matchingHazards regressionDevice use
2024
Prediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication
Peri-Okonny P, Romain G, Callegari S, Cleman J, Vashist A, Smolderen K, Mena-Hurtado C. Prediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication. Annals Of Vascular Surgery 2024, 110: 314-322. PMID: 39395588, DOI: 10.1016/j.avsg.2024.08.016.Peer-Reviewed Original ResearchHealth statusPeripheral arterial diseaseEQ-5D VASPeripheral vascular interventionsPredictor of future health statusPredictor of health statusDrug-Coated BalloonLower extremity peripheral arterial diseaseHealth status outcomesFuture health statusEQ-5D-3LHistory of deep venous thrombosisImprove patient outcomesStatus outcomesPrediction of health statusChronic lung diseaseDeep venous thrombosisPlain balloon angioplastyPatient outcomesDisease managementExtremity interventionsApproach to treatmentSD ageVenous thrombosisBaseline characteristicsFactors associated with sustained improvement after peripheral vascular intervention in patients with claudication
Peri-Okonny P, Romain G, Rambhujun V, Callegari S, Vashist A, Cleman J, Smolderen K, Mena-Hurtado C. Factors associated with sustained improvement after peripheral vascular intervention in patients with claudication. Vascular Medicine 2024, 29: 718-719. PMID: 39087625, DOI: 10.1177/1358863x241261369.Commentaries, Editorials and Letters
2022
Meta-Analysis Comparing Drug-Coated Balloons and Percutaneous Transluminal Angioplasty for Infrapopliteal Artery Disease
Barbarawi M, Qazi A, Lee J, Barbarawi O, Al-Abdouh A, Mhanna M, Vashist A. Meta-Analysis Comparing Drug-Coated Balloons and Percutaneous Transluminal Angioplasty for Infrapopliteal Artery Disease. The American Journal Of Cardiology 2022, 183: 115-121. PMID: 36116953, DOI: 10.1016/j.amjcard.2022.08.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPercutaneous transluminal balloon angioplastyDrug-coated balloonsConventional percutaneous transluminal balloon angioplastyMajor target limb amputationTarget limb amputationTarget lesion revascularizationCritical limb ischemiaInfrapopliteal arterial diseaseArterial diseaseLesion revascularizationCause mortalityLimb ischemiaArtery diseaseLimb amputationEfficacy of DCBUse of DCBInfrapopliteal peripheral arterial diseaseMajor adverse cardiovascular eventsEnd pointInfrapopliteal artery diseaseAdverse cardiovascular eventsPrimary end pointSecondary end pointsPeripheral arterial diseaseTransluminal balloon angioplasty
Academic Achievements & Community Involvement
Clinical Care
Overview
Aseem Vashist, MD, is a cardiologist specializing in cardiac imaging and interventional cardiology. He focuses on diagnosing and treating heart-related conditions, offering procedures that help visualize the heart's structure and function to guide treatment decisions.
As a professor of medicine at Yale School of Medicine, Dr. Vashist is involved in research aimed at improving diagnostic and therapeutic approaches in cardiovascular medicine. He received his medical training from the Armed Forces Medical College.
Clinical Specialties
Cardiovascular Medicine; Interventional Cardiology; Cardiac Imaging
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Yale Medicine
Cardiovascular Medicine , PO Box 208017
New Haven, CT 06520
United States
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