Jason Bini, PhD
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Biography
Jason earned his Ph.D. in Biomedical Engineering at The City College of New York, City University of New York in 2015. His dissertation focused on the validation and improvement of quantitative PET of atherosclerotic plaque metabolic activity using novel simultaneous PET/MR systems. Jason is currently using PET imaging to investigate mechanisms of disease and receptor/enzyme pharmacology in metabolic diseases, such as diabetes and obesity. Current projects include using PET to image dopamine in the pancreas both in type 1 and type 2 diabetes; whole-body distribution of the cortisol activating enzyme (11beta-hydroxysteroid dehydrogenase type 1); and method development (image reconstruction, attenuation and scatter correction) for whole-body kinetic modeling of novel PET radioligands in clinical and preclinical studies.
Appointments
Radiology & Biomedical Imaging
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellowship
- Yale University (2018)
- PhD
- The City College of New York (CUNY), Biomedical Engineering (2015)
- MS
- Stevens Institute of Technology, Biomedical Engineering (2010)
- BS
- Fordham University, Physics (2006)
Research
Overview
Medical Research Interests
Adipose Tissue; Biomedical Engineering; Brain; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Endocrinology; Liver; Neuroendocrinology; Obesity; Pancreas; Positron Emission Tomography Computed Tomography; Stress, Physiological; Whole Body Imaging
ORCID
0000-0003-4047-6575
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jason Bini's published research.
Publications Timeline
A big-picture view of Jason Bini's research output by year.
Research Interests
Research topics Jason Bini is interested in exploring.
Richard Carson, PhD
Nabeel Nabulsi, PhD
Mika Naganawa, PhD
Jean-Dominique Gallezot, PhD
Soheila Najafzadeh
Ania Jastreboff, MD, PhD
32Publications
941Citations
Brain
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Whole Body Imaging
Positron Emission Tomography Computed Tomography
Pancreas
Publications
2024
The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease
Bini J. The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease. Journal Of Alzheimer's Disease 2024, 99: 113-115. PMID: 38607759, DOI: 10.3233/jad-231463.Peer-Reviewed Original ResearchMeSH Keywords and Concepts
2023
The historical progression of positron emission tomography research in neuroendocrinology
Bini J. The historical progression of positron emission tomography research in neuroendocrinology. Frontiers In Neuroendocrinology 2023, 70: 101081. PMID: 37423505, PMCID: PMC10530506, DOI: 10.1016/j.yfrne.2023.101081.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyPositron emission tomography researchEmission Tomography ImagingPositron emission tomography (PET) imagingNumber of radiopharmaceuticalsEndocrine organSystematic reviewEmission tomographyPET radioligandHormone actionTomography imagingPET imagingDifferent receptorsHuman brainPET researchImagingSystem actionsSteroidsCliniciansRadioligandHormoneBrainProgressionReceptors
2022
Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo
Bini J, Carson R, Cline G. Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo. Methods In Molecular Biology 2022, 2592: 61-74. PMID: 36507985, DOI: 10.1007/978-1-0716-2807-2_4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyBeta-cell massFunctional beta-cell massDopamine D2/D3 receptorsD2/D3 receptorsBeta-cell lossType 2 diabetesEfficacy of therapeuticsQuantitative positron emission tomographyInsulin secretionDopamine receptorsD3 receptorsGlucose regulationPET radioligandEmission tomographyType 1Clinical usePET imagingReceptorsQuantitative PET imagingVMAT2Cellular transportersImagingVivoQuantitative imagingStress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networksFeasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET
Rossano S, Toyonaga T, Bini J, Nabulsi N, Ropchan J, Cai Z, Huang Y, Carson RE. Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET. EJNMMI Physics 2022, 9: 32. PMID: 35503134, PMCID: PMC9065222, DOI: 10.1186/s40658-022-00464-0.Peer-Reviewed Original ResearchCitationsConceptsFull spinal cordSpinal cord injuryHuman spinal cordSpinal cordAmyotrophic lateral sclerosisDistribution volume ratioCervical SCSynaptic densitySynaptic vesicle protein 2ACervical spinal cordBrain gray matterUse of PETBaseline VTWhole-body imagesSynapse lossCord injuryLateral sclerosisInjury severityGray matterNeurodegenerative disordersCordProtein 2AHuman dataDVR valuesCurrent standard
2021
The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review
Bini J, Norcross M, Cheung M, Duffy A. The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review. Obesity Surgery 2021, 31: 4592-4606. PMID: 34304378, DOI: 10.1007/s11695-021-05576-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyBariatric surgeryEmission tomographyBariatric surgery researchMalabsorption of foodBlood flowWhole-body PET imagingRadioligand developmentWeight lossPET imagingAmount of foodSurgery researchPhysiological effectsSurgeryPicomolar concentrationsTomographyRadioactive moleculesMetabolismMalabsorptionObesityPatientsFoodStomachPharmacologyReceptorsOptimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET
Bini J, Lattin CR, Toyonaga T, Finnema SJ, Carson R. Optimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 454-462. PMID: 36185820, PMCID: PMC9524424, DOI: 10.1109/trpms.2021.3088606.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J
Bini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J. EJNMMI Research 2020, 10: 83. PMID: 32666239, PMCID: PMC7359974, DOI: 10.1186/s13550-020-00670-w.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDose-limiting organUrinary bladderTime-activity curvesSynaptic densityOLINDA/EXM 1.0 softwareWhole-body PET scansWhole-body scanHuman adultsDose limitTotal radiation doseGastrointestinal tractPET scansHealthy adultsInjected activityRegion of interestLarge intestineNeuropsychiatric disordersEffective doseRelevant disordersBladderLiverRadiation doseAdultsMBqHigh uptakeReply: 11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes
Bini J, Carson RE, Cline GW. Reply: 11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes. Journal Of Nuclear Medicine 2020, 61: 1693-1693. PMID: 32620703, DOI: 10.2967/jnumed.120.250985.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsBody Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study
Bini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study. Molecular Imaging And Biology 2020, 22: 1124-1131. PMID: 32133575, PMCID: PMC7351613, DOI: 10.1007/s11307-020-01490-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBody mass indexPositron emission tomographyDehydrogenase type 1Mass indexObese individualsEnzyme 11β-hydroxysteroid dehydrogenase type 1Whole brainType 1Higher body mass indexPositron emission tomography studyVT valuesSevere Alzheimer's diseaseEmission tomography studiesSteroid stress hormonesAge-associated increaseMean whole brainSignificant age-associated increaseRegional distribution volumesVisceral adiposityInsulin resistanceActive cortisolExcess cortisolInactive cortisoneMemory dysfunctionParietal lobe
Clinical Trials
Current Trials
Imaging cortisol metabolism in liver, adipose tissue and brain with a novel PET radioligand
HIC ID2000029576RolePrincipal InvestigatorPrimary Completion Date06/30/2024Recruiting ParticipantsImaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
HIC ID2000021287RolePrincipal InvestigatorPrimary Completion Date07/31/2021Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
honor First Place in General Clinical Specialties
International AwardSociety for Nuclear Medicine and Molecular ImagingDetails07/07/2022Canadahonor Janeway Society Member
Regional AwardYale UniversityDetails07/01/2022United Stateshonor NIH NCATS YCCI Scholar Award
National AwardNIH/Yale Center for Clinical InvestigationDetails06/01/2020United Stateshonor 3rd place, Young Investigator Award, Computer and Instrumentation Council
International AwardSociety of Nuclear Medicine and Molecular ImagingDetails06/26/2018United States
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