Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsThomas D'Hooghe, MD, PhD
Professor (Adjunct) of Obstetrics, Gynecology, and Reproductive SciencesAbout
Research
Publications
2026
Expert opinion on best practice in programmed frozen embryo transfers: a Delphi consensus
Ata B, Devine K, Humaidan P, Mumusoglu S, Velasco J, Wu I, Schwarze J, D’Hooghe T, Yarali H, Group C. Expert opinion on best practice in programmed frozen embryo transfers: a Delphi consensus. Reproductive BioMedicine Online 2026, 105820. DOI: 10.1016/j.rbmo.2026.105820.Peer-Reviewed Original ResearchFrozen embryo transferProgrammed frozen embryo transferEmbryo transferFrozen embryo transfer protocolsDuration of progesterone treatmentLuteal phase supportDuration of estrogen supplementationProgesterone therapyPregnancy outcomesSerum estrogenEstrogen supplementationProgesterone treatmentProgesterone levelsLuteinising hormonePhase supportDelphi consensusLevel of agreementDurationOutcomesExpert opinionInternational expertsPregnancyEstrogenLuteinisingTherapyReply of the authors: Trial emulation and clinical trials
Schisterman E, Schwarze J, Platt R, Venetis C, Tennant P, Barnhart K, D'Hooghe T. Reply of the authors: Trial emulation and clinical trials. Fertility And Sterility 2026, 125: 732-733. PMID: 41956637, DOI: 10.1016/j.fertnstert.2025.12.010.Peer-Reviewed Original ResearchAssociation between trial registration and reporting large treatment effects in randomized controlled trials of infertility interventions: a meta-epidemiological study
Feng Q, Li W, Crispin J, Longobardi S, D'Hooghe T, Li W, Mol B. Association between trial registration and reporting large treatment effects in randomized controlled trials of infertility interventions: a meta-epidemiological study. Fertility And Sterility 2026, 126: 150-159. PMID: 41921890, DOI: 10.1016/j.fertnstert.2026.03.031.Peer-Reviewed Original ResearchConceptsMeta-epidemiological studyRandomized Controlled TrialsTrial registration statusRetrospectively registered trialsLarger treatment effectsSecondary analysisLive birthsSecondary analyses of randomized controlled trialsProspective registrationSystematic reviewSystematic searchStatistically significant relative riskSystematic searches of EMBASETreatment effectsRegistration statusAnalysis of randomized controlled trialsSearch of EmbaseSignificant relative riskStatistical powerPoisson regressionPotential confoundersEligible randomized controlled trialsRelative riskControlled TrialsPrimary outcomeIntrapatient variability in the number of retrieved oocytes and ovarian response categories between consecutive in vitro fertilization cycles
Hochberg A, Reuvenny S, Itzhak N, Luz A, Hourvitz R, Moran E, Polyzos N, Hariton E, Zheng W, D'Hooghe T, Maman E, Baum M, Youngster M, Hourvitz A. Intrapatient variability in the number of retrieved oocytes and ovarian response categories between consecutive in vitro fertilization cycles. Fertility And Sterility 2026, 125: 1056-1066. PMID: 41856348, DOI: 10.1016/j.fertnstert.2026.03.020.Peer-Reviewed Original ResearchOvarian response categoriesOocyte yieldOvarian stimulationIntra-patient variabilityOS protocolOS cyclesConsecutive in vitro fertilizationPercentage changeOocyte countMature oocyte yieldConsecutive IVF cyclesMedian percentage changeAge groupsGonadotropin typeRetrieved oocytesGonadotropin dosageIVF cyclesBaseline characteristicsDaily dosePatient baseline profilesHyper-responsivenessOocyte numberPrimary outcomeSecondary outcomesPatientsEffectiveness of 12-month GnRH antagonist treatment for endometriosis-associated pain: driven by reduction in uterine bleeding?
D’Hooghe T. Effectiveness of 12-month GnRH antagonist treatment for endometriosis-associated pain: driven by reduction in uterine bleeding? Human Reproduction Open 2026, 2026: hoag031. PMID: 42077503, PMCID: PMC13135357, DOI: 10.1093/hropen/hoag031.Peer-Reviewed Original ResearchComparative Effectiveness of Recombinant Human Follicle-Stimulating Hormone:Recombinant Human Luteinizing Hormone in a 2:1 Ratio versus Highly Purified Human Menopausal Gonadotropin Alone in Ovarian Stimulation for Medically Assisted Reproduction Treatment Using in vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis
Dahan M, Schwarze J, Gupta S, Hayward B, Fischer R, Esteves S, Chen M, Silverberg K, Guzmán L, Santi D, Feferkorn I, D’Hooghe T, Alviggi C. Comparative Effectiveness of Recombinant Human Follicle-Stimulating Hormone:Recombinant Human Luteinizing Hormone in a 2:1 Ratio versus Highly Purified Human Menopausal Gonadotropin Alone in Ovarian Stimulation for Medically Assisted Reproduction Treatment Using in vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis. Gynecologic And Obstetric Investigation 2026, 1-14. PMID: 41729769, PMCID: PMC13065304, DOI: 10.1159/000550420.Peer-Reviewed Original ResearchClinical pregnancy rateHP-hMGOvarian stimulationR-hLHPregnancy rateR-hFSHOocyte numberMedically assisted reproduction treatmentsRecombinant human luteinizing hormoneGood-quality embryosLive birth rateRecombinant human follicle stimulating hormoneLive birth outcomesHuman menopausal gonadotropinMeta-analysisDay 1Secondary outcomesHuman follicle stimulating hormoneReproduction treatmentBirth rateMeta-analysis of published evidenceFollicle stimulating hormoneCross-over studyNon-interventional studyMenopausal gonadotropin
2025
Live birth in patients stimulated with r-hFSH or r-hFSH: r-hLH is strongly associated with cumulus cell derived gene expression models
Adriaenssens T, Van Vaerenbergh I, Van Leuven W, Coucke W, Montenegro S, Zheng W, D’Hooghe T, Van Landuyt L, De Munck N, Van Hecke E, Smitz J, Rosenthal A, Blockeel C. Live birth in patients stimulated with r-hFSH or r-hFSH: r-hLH is strongly associated with cumulus cell derived gene expression models. Reproductive Biology And Endocrinology 2025, 23: 163. PMID: 41275247, PMCID: PMC12751414, DOI: 10.1186/s12958-025-01480-2.Peer-Reviewed Original ResearchConceptsR-hFSHR-hLHStudy groupTime-to-pregnancyCumulus cellsICSI patientsLive birthsBiomarker expressionCumulus cells of oocytesMethodsThis observational cohort studyUZ BrusselInterventional prospective studyObservational cohort studyEthics CommitteePGT-AHP-hMGIVF/ICSI cyclesPredictive biomarkersProspective studyART cyclesCohort studyGene expression profilesPatient characteristicsPatient groupEmbryo assessmentConsistency in treatment effects and statistical significance between early-stage pregnancy endpoints and live birth in randomized controlled trials of infertility: a systematic meta-epidemiological study
Feng Q, Li W, Crispin J, Longobardi S, D'Hooghe T, Li W, Mol B. Consistency in treatment effects and statistical significance between early-stage pregnancy endpoints and live birth in randomized controlled trials of infertility: a systematic meta-epidemiological study. Fertility And Sterility 2025, 125: 356-366. PMID: 40876726, DOI: 10.1016/j.fertnstert.2025.08.025.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPregnancy EndpointsRandomized Controlled TrialsLive birthsClinical pregnancyLive birth dataStatistical significanceInfertility treatmentBirth dataMedically assisted reproduction treatmentsTreatment effectsMeta-epidemiological studyCorrelation of treatment effectsBiochemical pregnancySpearman's rhoChi-square testOvarian stimulationSubfertile womenPregnancy lossPregnancy dataPregnancyReproduction treatmentControlled TrialsGold standardInfertilityEndpointWeighing Parenthood Wishes: A Conjoint Analysis of Criteria to Prioritize Infertile Couples for Publicly Funded Fertility Treatment
Van Muylder A, Kessels R, D’Hooghe T, Luyten J. Weighing Parenthood Wishes: A Conjoint Analysis of Criteria to Prioritize Infertile Couples for Publicly Funded Fertility Treatment. Medical Decision Making 2025, 45: 1034-1051. PMID: 40826820, DOI: 10.1177/0272989x251353524.Peer-Reviewed Original ResearchBiological childrenIn vitro fertilizationInfertility causeCost of IVF treatmentPublic fundsSame-sex relationshipsPartner ageCivil statusFertilizer treatmentsLife goalsFunding prioritiesPublic supportBelgian populationBelgian policyHard choicesIVF treatmentInfertile couplesPolicy makersFunding policiesPolicyLogit modelInfertilitySociodemographic groupsDiscrete-choice experimentFundingA commentary on “Online fertility workup with video consultation for infertility patients; a randomized controlled trial”
Zheng W, Schwarze J, D'Hooghe T. A commentary on “Online fertility workup with video consultation for infertility patients; a randomized controlled trial”. Fertility And Sterility 2025, 124: 456-457. PMID: 40614894, DOI: 10.1016/j.fertnstert.2025.06.042.Commentaries, Editorials and Letters