2017
FFAR2‐FFAR3 receptor heteromerization modulates short‐chain fatty acid sensing
Ang Z, Xiong D, Wu M, Ding JL. FFAR2‐FFAR3 receptor heteromerization modulates short‐chain fatty acid sensing. The FASEB Journal 2017, 32: 289-303. PMID: 28883043, PMCID: PMC5731126, DOI: 10.1096/fj.201700252rr.Peer-Reviewed Original ResearchMeSH KeywordsBeta-Arrestin 2Calcium SignalingColitisCyclic AMPFatty Acids, VolatileFluorescence Resonance Energy TransferHEK293 CellsHumansMacrophagesObesityP38 Mitogen-Activated Protein KinasesPhosphorylationProtein MultimerizationReceptors, Cell SurfaceReceptors, G-Protein-CoupledRecombinant ProteinsConceptsShort-chain fatty acidsBimolecular fluorescence complementationReceptor heteromerizationGut microbiota-derived short-chain fatty acidsMicrobiota-derived short-chain fatty acidsFluorescence complementationFluorescence resonance energy transferHeterologous expressionFree fatty acid receptor 2Mammalian receptorsFatty acidsFatty acid sensingProximity ligationDrug targetsΒ-arrestinHEK293 cellsPrimary human monocytesResonance energy transferNovel pathwayCytosolic CaP38 phosphorylationHeteromersInflammatory monocytesReceptor 2Receptor heteromers
2013
Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations
Wu M, Wu X, De Camilli P. Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 1339-1344. PMID: 23297209, PMCID: PMC3557052, DOI: 10.1073/pnas.1221538110.Peer-Reviewed Original ResearchConceptsPlasma membraneActin regulatory proteinsActin cytoskeletonActin dynamicsActive Cdc42Cell cortexCell physiologyRegulatory proteinsActin polymerizationDynamic spatial patternsMacromolecular assembliesCalcium oscillationsSpatial patternsActinMembraneFBP17Cdc42CellsCytoskeletonFeedback mechanismProteinPhysiologyAntigen stimulationGlobal fluctuationsMechanism