2024
Glucosamine mitigates ischemia-reperfusion-induced acute kidney injury through anti-inflammatory mechanisms
Zhang G, Jin S, Fan X, Qi J, Liu J, Yin S, Cao Y, Du Y, Dong X, Wang Z, Tan X, Yan S. Glucosamine mitigates ischemia-reperfusion-induced acute kidney injury through anti-inflammatory mechanisms. Frontiers In Materials 2024, 11: 1438610. DOI: 10.3389/fmats.2024.1438610.Peer-Reviewed Original ResearchAcute kidney injuryTubular epithelial cellsKidney injuryI/R injuryRenal tissueEpithelial cellsInflammatory responseRenal ischemia-reperfusion (I/R) injuryIschemia-reperfusion-induced acute kidney injuryI/R-induced acute kidney injuryEndoplasmic reticulumIschemia-reperfusion (I/R) injuryProximal tubular epithelial cellsMarkers of oxidative stressEfficacy of glucosaminePotential therapeutic efficacyProximal convoluted tubular epithelial cellsRenal interstitial fibrosisI/R injury modelAnti-inflammatory actionMitigate ER stressAnti-inflammatory mechanismsAssessed in vitroOxidative stress levelsReduced oxidative stress levels
2021
The GUL-1 Protein Binds Multiple RNAs Involved in Cell Wall Remodeling and Affects the MAK-1 Pathway in Neurospora crassa
Herold I, Zolti A, Garduño-Rosales M, Wang Z, López-Giráldez F, Mouriño-Pérez R, Townsend J, Ulitsky I, Yarden O. The GUL-1 Protein Binds Multiple RNAs Involved in Cell Wall Remodeling and Affects the MAK-1 Pathway in Neurospora crassa. Frontiers In Fungal Biology 2021, 2: 672696. PMID: 37744127, PMCID: PMC10512220, DOI: 10.3389/ffunb.2021.672696.Peer-Reviewed Original ResearchCell wall integrityRNA-binding proteinCell wall remodelingGul-1Endoplasmic reticulumCell wallGenomic RNA speciesP-body proteinsPolar hyphal growthMultiple cellular processesMAPK pathway componentsWall remodelingAdditional RNA-binding proteinsAltered phosphorylation levelsSTRIPAK complexCot-1Cellular processesRNA speciesMultiple RNAsNeurospora crassaHyphal growthMAK-1Wall integrityBind mRNAsCircadian clock