2015
A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Heilmann S, Ratnakumar K, Langdon E, Kansler E, Kim I, Campbell N, Perry E, McMahon A, Kaufman C, van Rooijen E, Lee W, Iacobuzio-Donahue C, Hynes R, Zon L, Xavier J, White R. A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Research 2015, 75: 4272-4282. PMID: 26282170, PMCID: PMC4609292, DOI: 10.1158/0008-5472.can-14-3319.Peer-Reviewed Original ResearchConceptsSingle-cell resolutionStable cell linesZebrafish systemTransparent zebrafishMetastasis-initiating cellsHuman cell culture systemsHigh-throughput investigationCell culture systemComputational image analysisMetastatic biologyMetastatic capabilityCell linesMetastatic capacityMelanoma cellsMetastatic processRapid generationCulture systemSuperior imaging toolCellsMitfaZebrafishMetastasis ScoreDegree of pigmentationBiologyProgeny
2008
Identifying the fundamental units of bacterial diversity: A paradigm shift to incorporate ecology into bacterial systematics
Koeppel A, Perry E, Sikorski J, Krizanc D, Warner A, Ward D, Rooney A, Brambilla E, Connor N, Ratcliff R, Nevo E, Cohan F. Identifying the fundamental units of bacterial diversity: A paradigm shift to incorporate ecology into bacterial systematics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 2504-2509. PMID: 18272490, PMCID: PMC2268166, DOI: 10.1073/pnas.0712205105.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBacillusComputer SimulationEcologyEnvironmental PollutionMolecular Sequence DataPhylogenyConceptsBacterial systematicsNatural communitiesSequence-based approachesEvolution CanyonBacterial domainEcotype SimulationSuch ecotypesMicrobial ecologyDistinct lineagesMultiple ecotypesEvolutionary dynamicsBacterial diversityDifferent solar exposureTraditional speciesBacterial populationsBacterial ecologyEcotypesBacterial cellsEcologyDistinct rolesSystematicsFundamental unitDiverse setCladeLineages