The Molecular and Genetic Basis of Repeatable Coevolution between Escherichia coli and Bacteriophage T3 in a Laboratory Microcosm
Perry E, Barrick J, Bohannan B. The Molecular and Genetic Basis of Repeatable Coevolution between Escherichia coli and Bacteriophage T3 in a Laboratory Microcosm. PLOS ONE 2015, 10: e0130639. PMID: 26114300, PMCID: PMC4482675, DOI: 10.1371/journal.pone.0130639.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionBacteriophage T3Directed Molecular EvolutionEscherichia coliEscherichia coli ProteinsGlucosyltransferasesMutation, MissenseViral ProteinsConceptsBacteriophage T3Repeatable evolutionEscherichia coli BCoevolution experimentMutant phageFunction mutationsColi BLevel of pathwaysNucleotide levelLaboratory microcosmsPhage tail fibersSame ancestral strainBacterial ancestorAncestral phageConvergent evolutionContinuous culture deviceGenomic changesGenetic basisSingle codonNew phage typePhage interactionsDifferent genesTail fibersAncestral strainGenetic changes