Publications

• Akt is a mediator of artery specification during zebrafish development.Zhou W, Ghersi JJ, Ristori E, Semanchik N, Prendergast A, Zhang R, Carneiro P, Baldissera G, Sessa WC, Nicoli S. Development. 2024 Sep 1; 2024 Sep 2. PMID: 39101673.
• ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani MN, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin JE, Sessa WC, Ishibe S, Jane-Wit D. Kidney Int. 2024 Sep; 2024 May 24. PMID: 38797325.
• Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice.Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC. Cancer Cell. 2024 Jun 10; 2024 May 30. PMID: 38821059.
• Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice.Boutagy NE, Gamez-Mendez A, Fowler JW, Zhang H, Chaube BK, Esplugues E, Kuo A, Lee S, Horikami D, Zhang J, Citrin KM, Singh AK, Coon BG, Lee MY, Suarez Y, Fernandez-Hernando C, Sessa WC. J Clin Invest. 2024 Jan 4; 2024 Jan 4. PMID: 38175710.
• Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma.Singh AK, Chaube B, Citrin KM, Fowler JW, Lee S, Catarino J, Knight J, Lowery S, Shree S, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross TT, Malaker S, Suárez Y, Fernández-Hernando C, Grabinska K, Sessa WC. bioRxiv. 2023 Nov 15; 2023 Nov 15. PMID: 38014178.
• Endothelial nitric oxide synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation.Nguyen TD, Rahman NT, Sessa WC, Lee MY. Front Cardiovasc Med. 2023; 2023 Nov 14. PMID: 38034389.
• TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes.Boutagy NE, Fowler JW, Grabinska KA, Cardone R, Sun Q, Vazquez KR, Whalen MB, Zhu X, Chakraborty R, Martin KA, Simons M, Romanoski CE, Kibbey RG, Sessa WC. Proc Natl Acad Sci U S A. 2023 Sep 19; 2023 Sep 11. PMID: 37695914.
• SREBP2 regulates the endothelial response to cytokines via direct transcriptional activation of KLF6.Fowler JWM, Boutagy NE, Zhang R, Horikami D, Whalen MB, Romanoski CE, Sessa WC. J Lipid Res. 2023 Aug; 2023 Jul 10. PMID: 37437844.
• Acetate controls endothelial-to-mesenchymal transition.Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Cell Metab. 2023 Jul 11; 2023 Jun 15. PMID: 37327791.
• An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells.Zhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk BE, Sessa WC, Liu Y. Nat Commun. 2023 Jun 26; 2023 Jun 26. PMID: 37365174.
• Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice.Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul PW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. Nat Cardiovasc Res. 2023 May; 2023 May 11. PMID: 39196046.
• Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling.Canfrán-Duque A, Rotllan N, Zhang X, Andrés-Blasco I, Thompson BM, Sun J, Price NL, Fernández-Fuertes M, Fowler JW, Gómez-Coronado D, Sessa WC, Giannarelli C, Schneider RJ, Tellides G, McDonald JG, Fernández-Hernando C, Suárez Y. Circulation. 2023 Jan 31; 2022 Nov 23. PMID: 36416142.
• Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
• Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells.Fowler JWM, Zhang R, Tao B, Boutagy NE, Sessa WC. Elife. 2022 Aug 12; 2022 Aug 12. PMID: 35959888.
• Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Circulation. 2022 Jun 7; 2022 May 3. PMID: 35502657.
• De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus.Galosi S, Edani BH, Martinelli S, Hansikova H, Eklund EA, Caputi C, Masuelli L, Corsten-Janssen N, Srour M, Oegema R, Bosch DGM, Ellis CA, Amlie-Wolf L, Accogli A, Atallah I, Averdunk L, Barañano KW, Bei R, Bagnasco I, Brusco A, Demarest S, Alaix AS, Di Bonaventura C, Distelmaier F, Elmslie F, Gan-Or Z, Good JM, Gripp K, Kamsteeg EJ, Macnamara E, Marcelis C, Mercier N, Peeden J, Pizzi S, Pannone L, Shinawi M, Toro C, Verbeek NE, Venkateswaran S, Wheeler PG, Zdrazilova L, Zhang R, Zorzi G, Guerrini R, Sessa WC, Lefeber DJ, Tartaglia M, Hamdan FF, Grabińska KA, Leuzzi V. Brain. 2022 Mar 29. PMID: 34382076.
• Targeting the vasculature in cardiometabolic disease.Boutagy NE, Singh AK, Sessa WC. J Clin Invest. 2022 Mar 15. PMID: 35289308.
• The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.Ribera J, Portolés I, Córdoba-Jover B, Rodríguez-Vita J, Casals G, González-de la Presa B, Graupera M, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernández-Checa JC, Soria G, Tudela R, Esteve-Codina A, Espadas G, Sabidó E, Jiménez W, Sessa WC, Morales-Ruiz M. Commun Biol. 2021 Oct 15; 2021 Oct 15. PMID: 34654883.
• Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia.Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Circulation. 2021 Sep 7; 2021 Jun 29. PMID: 34182767.
• Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease.Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. J Hepatol. 2021 Aug; 2021 Mar 3. PMID: 33675874.
• Eruptive xanthoma model reveals endothelial cells internalize and metabolize chylomicrons, leading to extravascular triglyceride accumulation.Cabodevilla AG, Tang S, Lee S, Mullick AE, Aleman JO, Hussain MM, Sessa WC, Abumrad NA, Goldberg IJ. J Clin Invest. 2021 Jun 15. PMID: 34128469.
• Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation.Bernatchez PN, Tao B, Bradshaw RA, Eveleth D, Sessa WC. Transl Vis Sci Technol. 2021 May 3. PMID: 34111267.
• Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.Yuan Q, Basit A, Liang W, Qu R, Luan Y, Ren C, Li A, Xu X, Liu X, Yang C, Kuo A, Pierce R, Zhang L, Turk B, Hu X, Li F, Cui W, Li R, Huang D, Mo L, Sessa WC, Lee PJ, Kluger Y, Su B, Tang W, He J, Wu D. Sci Transl Med. 2021 Apr 28. PMID: 33910977.
• eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Claesson-Welsh L. Elife. 2021 Apr 28; 2021 Apr 28. PMID: 33908348.
• Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.Courage C, Oliver KL, Park EJ, Cameron JM, Grabińska KA, Muona M, Canafoglia L, Gambardella A, Said E, Afawi Z, Baykan B, Brandt C, di Bonaventura C, Chew HB, Criscuolo C, Dibbens LM, Castellotti B, Riguzzi P, Labate A, Filla A, Giallonardo AT, Berecki G, Jackson CB, Joensuu T, Damiano JA, Kivity S, Korczyn A, Palotie A, Striano P, Uccellini D, Giuliano L, Andermann E, Scheffer IE, Michelucci R, Bahlo M, Franceschetti S, Sessa WC, Berkovic SF, Lehesjoki AE. Am J Hum Genet. 2021 Apr 1. PMID: 33798445.
• BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells.Tao B, Kraehling JR, Ghaffari S, Ramirez CM, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. J Biol Chem. 2020 Dec 25; 2020 Oct 23. PMID: 33097593.
• The N-glycome regulates the endothelial-to-hematopoietic transition.Kasper DM, Hintzen J, Wu Y, Ghersi JJ, Mandl HK, Salinas KE, Armero W, He Z, Sheng Y, Xie Y, Heindel DW, Park EJ, Sessa WC, Mahal LK, Lebrilla C, Hirschi KK, Nicoli S. Science. 2020 Dec 4; 2020 Dec 3. PMID: 33273096.
• Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension.Song L, Chen X, Swanson TA, LaViolette B, Pang J, Cunio T, Nagle MW, Asano S, Hales K, Shipstone A, Sobon H, Al-Harthy SD, Ahn Y, Kreuser S, Robertson A, Ritenour C, Voigt F, Boucher M, Sun F, Sessa WC, Roth Flach RJ. Elife. 2020 Nov 17; 2020 Nov 17. PMID: 33200983.
• Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.Edani BH, Grabińska KA, Zhang R, Park EJ, Siciliano B, Surmacz L, Ha Y, Sessa WC. Proc Natl Acad Sci U S A. 2020 Aug 25; 2020 Aug 12. PMID: 32817466.
• A Vectorial, ER-Mitochondria Link to Energy Homeostasis in the Vascular Endothelium.Boutagy NE, Fowler JW, Sessa WC. Cell Metab. 2020 Aug 4. PMID: 32755606.
• Dynamic Protein Palmitoylation Cycling: A New Pathway Impacting Peripheral Arterial Disease?Boutagy NE, Sessa WC. Circ Res. 2020 Jul 3; 2020 Jul 2. PMID: 32614718.
• Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis.Zhang X, Ramírez CM, Aryal B, Madrigal-Matute J, Liu X, Diaz A, Torrecilla-Parra M, Suárez Y, Cuervo AM, Sessa WC, Fernández-Hernando C. Arterioscler Thromb Vasc Biol. 2020 Jun; 2020 Apr 30. PMID: 32349535.
• Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase.Garcia V, Park EJ, Siragusa M, Frohlich F, Mahfuzul Haque M, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Proc Natl Acad Sci U S A. 2020 Apr 28; 2020 Apr 16. PMID: 32300005.
• Endothelial cell-glucocorticoid receptor interactions and regulation of Wnt signaling.Zhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. JCI Insight. 2020 Feb 13; 2020 Feb 13. PMID: 32051336.
• Caveolae: The FAQs.Parton RG, Del Pozo MA, Vassilopoulos S, Nabi IR, Le Lay S, Lundmark R, Kenworthy AK, Camus A, Blouin CM, Sessa WC, Lamaze C. Traffic. 2020 Jan; 2019 Sep 9. PMID: 31448516.
• Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR. Matrix Biol. 2019 Sep; 2019 Mar 13. PMID: 30876926.
• Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C. Circulation. 2019 Jul 16; 2019 Jun 3. PMID: 31154825.
• Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency.Hashimoto T, Isaji T, Hu H, Yamamoto K, Bai H, Santana JM, Kuo A, Kuwahara G, Foster TR, Hanisch JJ, Yatsula BA, Sessa WC, Hoshina K, Dardik A. Arterioscler Thromb Vasc Biol. 2019 Apr. PMID: 30786746.
• Shear Stress Attenuates Inward Remodeling in Cultured Mouse Thoracodorsal Arteries in an eNOS-Dependent, but Not Hemodynamic Manner, and Increases Cx37 Expression.Looft-Wilson RC, Billig JE, Sessa WC. J Vasc Res. 2019; 2019 Oct 1. PMID: 31574503.
• Endothelial NOS: perspective and recent developments.Garcia V, Sessa WC. Br J Pharmacol. 2019 Jan; 2018 Dec 9. PMID: 30341769.
• SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2.Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, Martin K, Sessa W, Dubrac A, Eichmann A. Circulation. 2018 Nov 20. PMID: 29976569.
• Estrogen Reduces LDL (Low-Density Lipoprotein) Transcytosis.Sessa WC. Arterioscler Thromb Vasc Biol. 2018 Oct. PMID: 30354224.
• Endothelial Transcytosis of Lipoproteins in Atherosclerosis.Zhang X, Sessa WC, Fernández-Hernando C. Front Cardiovasc Med. 2018; 2018 Sep 25. PMID: 30320124.
• Lacteal junction zippering protects against diet-induced obesity.Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A. Science. 2018 Aug 10. PMID: 30093598.
• CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues.Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC. J Biol Chem. 2018 Jun 8; 2018 Mar 27. PMID: 29588368.
• Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC. Arterioscler Thromb Vasc Biol. 2018 Apr; 2018 Feb 15. PMID: 29449333.
• Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin-stimulated, cAMP-mediated lipolysis.Kuo A, Lee MY, Yang K, Gross RW, Sessa WC. J Biol Chem. 2018 Jan 19; 2017 Dec 4. PMID: 29203526.
• HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR. Matrix Biol. 2018 Jan; 2017 Aug 5. PMID: 28789925.
• Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA. Arterioscler Thromb Vasc Biol. 2017 Dec; 2017 Oct 12. PMID: 29025710.
• Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae.Hoffmann R, Grabińska K, Guan Z, Sessa WC, Neiman AM. Genetics. 2017 Dec; 2017 Oct 4. PMID: 28978675.
• Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency.Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A. Sci Rep. 2017 Nov 13; 2017 Nov 13. PMID: 29133876.
• A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity.Grabińska KA, Edani BH, Park EJ, Kraehling JR, Sessa WC. J Biol Chem. 2017 Oct 20; 2017 Aug 23. PMID: 28842490.
• Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK.Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, Chen Q, Xing L, Wang B, Cao Y, Sessa WC, Ju R, Liu Y, Li X. Proc Natl Acad Sci U S A. 2017 Oct 3; 2017 Sep 18. PMID: 28923916.
• Mast cell-derived prostaglandin D(2) attenuates anaphylactic reactions in mice.Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T. J Allergy Clin Immunol. 2017 Aug; 2017 Apr 27. PMID: 28457595.
• Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression.Luciano AK, Santana JM, Velazquez H, Sessa WC. J Biol Rhythms. 2017 Jun; 2017 Apr 28. PMID: 28452287.
• Lipid Droplet Biogenesis and Function in the Endothelium.Kuo A, Lee MY, Sessa WC. Circ Res. 2017 Apr 14; 2017 Jan 24. PMID: 28119423.
• Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.Kraehling JR, Sessa WC. Circ Res. 2017 Mar 31. PMID: 28360348.
• PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A. Nat Commun. 2016 Nov 29; 2016 Nov 29. PMID: 27897192.
• Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Nat Commun. 2016 Nov 21; 2016 Nov 21. PMID: 27869117.
• cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases.Grabińska KA, Park EJ, Sessa WC. J Biol Chem. 2016 Aug 26; 2016 Jul 11. PMID: 27402831.
• Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice.Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. EMBO Mol Med. 2016 Jun; 2016 Jun 1. PMID: 27137489.
• Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report.Liu D, Lei L, Desir M, Huang Y, Cleman J, Jiang W, Fernandez-Hernando C, Di Lorenzo A, Sessa WC, Giordano FJ. Arterioscler Thromb Vasc Biol. 2016 Mar; 2016 Jan 21. PMID: 26800562.
• NgBR is essential for endothelial cell glycosylation and vascular development.Park EJ, Grabińska KA, Guan Z, Sessa WC. EMBO Rep. 2016 Feb; 2016 Jan 11. PMID: 26755743.
• The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC. Arterioscler Thromb Vasc Biol. 2016 Feb; 2015 Dec 29. PMID: 26715683.
• Uncoupling Caveolae From Intracellular Signaling In Vivo.Kraehling JR, Hao Z, Lee MY, Vinyard DJ, Velazquez H, Liu X, Stan RV, Brudvig GW, Sessa WC. Circ Res. 2016 Jan 8; 2015 Nov 24. PMID: 26602865.
• VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis.Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y. Circ Res. 2016 Jan 8; 2015 Oct 15. PMID: 26472816.
• Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling.Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW, Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC. Proc Natl Acad Sci U S A. 2015 Oct 13; 2015 Sep 28. PMID: 26417068.
• Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation.Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC. Sci Signal. 2015 Aug 18; 2015 Aug 18. PMID: 26286023.
• A randomized trial to assess the pharmacodynamics and pharmacokinetics of a single dose of an extended-release aspirin formulation.Patrick J, Dillaha L, Armas D, Sessa WC. Postgrad Med. 2015 Aug; 2015 May 22. PMID: 25998572.
• Enhanced eNOS Activation as the Fountain of Youth for Vascular Disease: Is BPIFB4 What Ponce de León Was Looking For?Kraehling JR, Sessa WC. Circ Res. 2015 Jul 31. PMID: 26227874.
• Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis.Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC, Fernández-Hernando C. Circ Res. 2015 May 22; 2015 Apr 13. PMID: 25868464.
• Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition.Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA. Sci Signal. 2015 May 12; 2015 May 12. PMID: 25969542.
• Endothelial glucocorticoid receptor suppresses atherogenesis--brief report.Goodwin JE, Zhang X, Rotllan N, Feng Y, Zhou H, Fernández-Hernando C, Yu J, Sessa WC. Arterioscler Thromb Vasc Biol. 2015 Apr; 2015 Feb 19. PMID: 25810297.
• Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C. FASEB J. 2015 Feb; 2014 Nov 12. PMID: 25392271.
• Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299.
• Inflammation and the blood microvascular system.Pober JS, Sessa WC. Cold Spring Harb Perspect Biol. 2014 Oct 23; 2014 Oct 23. PMID: 25384307.
• Loss of the endothelial glucocorticoid receptor prevents the therapeutic protection afforded by dexamethasone after LPS.Goodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC. PLoS One. 2014; 2014 Oct 9. PMID: 25299055.
• Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137.
• Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation.Park EJ, Grabińska KA, Guan Z, Stránecký V, Hartmannová H, Hodaňová K, Barešová V, Sovová J, Jozsef L, Ondrušková N, Hansíková H, Honzík T, Zeman J, Hůlková H, Wen R, Kmoch S, Sessa WC. Cell Metab. 2014 Sep 2; 2014 Jul 24. PMID: 25066056.
• Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis.Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR. Am J Pathol. 2014 May; 2014 Mar 5. PMID: 24606881.
• Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Development. 2014 Apr; 2014 Mar 5. PMID: 24598168.
• Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry.Jozsef L, Tashiro K, Kuo A, Park EJ, Skoura A, Albinsson S, Rivera-Molina F, Harrison KD, Iwakiri Y, Toomre D, Sessa WC. J Biol Chem. 2014 Mar 28; 2014 Feb 20. PMID: 24558039.
• Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M. J Biol Chem. 2014 Jan 3; 2013 Nov 14. PMID: 24235146.
• eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. J Cell Sci. 2013 Dec 15; 2013 Sep 17. PMID: 24046447.
• The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling.Kondo Y, Jadlowiec CC, Muto A, Yi T, Protack C, Collins MJ, Tellides G, Sessa WC, Dardik A. PLoS One. 2013; 2013 Nov 20. PMID: 24278366.
• Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size.Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Stroke. 2013 Nov; 2013 Aug 29. PMID: 23988642.
• Differential regulation of cell functions by CSD peptide subdomains.Reese C, Dyer S, Perry B, Bonner M, Oates J, Hofbauer A, Sessa W, Bernatchez P, Visconti RP, Zhang J, Hatfield CM, Silver RM, Hoffman S, Tourkina E. Respir Res. 2013 Sep 8; 2013 Sep 8. PMID: 24011378.
• Hypoxia-inducible factor-1α in vascular smooth muscle regulates blood pressure homeostasis through a peroxisome proliferator-activated receptor-γ-angiotensin II receptor type 1 axis.Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ. Hypertension. 2013 Sep; 2013 Aug 5. PMID: 23918749.
• Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.Zhang P, Huang B, Xu X, Sessa WC. Biochem Biophys Res Commun. 2013 Aug 2; 2013 Jun 29. PMID: 23820384.
• Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival.Siragusa M, Sessa WC. Arterioscler Thromb Vasc Biol. 2013 Aug; 2013 May 23. PMID: 23702662.
• Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G. Arterioscler Thromb Vasc Biol. 2013 May; 2013 Mar 14. PMID: 23493289.
• NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. J Clin Invest. 2013 Apr. PMID: 23454748.
• eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity.Kashiwagi S, Atochin DN, Li Q, Schleicher M, Pong T, Sessa WC, Huang PL. Biochem Biophys Res Commun. 2013 Feb 8; 2013 Jan 3. PMID: 23291238.
• miRNAs as modulators of angiogenesis.Landskroner-Eiger S, Moneke I, Sessa WC. Cold Spring Harb Perspect Med. 2013 Feb 1; 2013 Feb 1. PMID: 23169571.
• IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 2012 Nov 2. PMID: 23125252.
• Endothelial glucocorticoid receptor is required for protection against sepsis.Goodwin JE, Feng Y, Velazquez H, Sessa WC. Proc Natl Acad Sci U S A. 2013 Jan 2; 2012 Dec 17. PMID: 23248291.
• Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk.Chick HE, Nowrouzi A, Fronza R, McDonald RA, Kane NM, Alba R, Delles C, Sessa WC, Schmidt M, Thrasher AJ, Baker AH. Hum Gene Ther. 2012 Dec; 2012 Oct 26. PMID: 22931362.
• Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aortic stenosis.Zhang P, Huang A, Morales-Ruiz M, Starcher BC, Huang Y, Sessa WC, Niklason LE, Giordano FJ. Hum Gene Ther. 2012 Nov. PMID: 22891920.
• A new approach to weight loss: just activate endothelial NO synthase!Sessa WC. Circ Res. 2012 Oct 12. PMID: 23065339.
• Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.Marin EP, Derakhshan B, Lam TT, Davalos A, Sessa WC. Circ Res. 2012 May 11; 2012 Apr 10. PMID: 22496122.