Publications

• Imaging Proteins Sensitive to Direct Fusions Using Transient Peptide-Peptide Interactions.Gidden Z, Oi C, Johnston EJ, Konieczna Z, Bhaskar H, Mendive-Tapia L, de Moliner F, Rosser SJ, Mochrie SGJ, Vendrell M, Horrocks MH, Regan L. Nano Lett. 2023 Nov 22; 2023 Nov 2. PMID: 37916770.
• Uncovering diffusive states of the yeast membrane protein, Pma1, and how labeling method can change diffusive behavior.Bailey MLP, Pratt SE, Hinrichsen M, Zhang Y, Bewersdorf J, Regan LJ, Mochrie SGJ. Eur Phys J E Soft Matter. 2023 Jun 9; 2023 Jun 9. PMID: 37294385.
• Core packing of well-defined X-ray and NMR structures is the same.Grigas AT, Liu Z, Regan L, O'Hern CS. Protein Sci. 2022 Aug. PMID: 35900019.
• PAINT using proteins: A new brush for super-resolution artists.Oi C, Mochrie SGJ, Horrocks MH, Regan L. Protein Sci. 2020 Nov; 2020 Sep 25. PMID: 32949055.
• Using physical features of protein core packing to distinguish real proteins from decoys.Grigas AT, Mei Z, Treado JD, Levine ZA, Regan L, O'Hern CS. Protein Sci. 2020 Sep. PMID: 32710566.
• Analyses of protein cores reveal fundamental differences between solution and crystal structures.Mei Z, Treado JD, Grigas AT, Levine ZA, Regan L, O'Hern CS. Proteins. 2020 Sep; 2020 Mar 5. PMID: 32105366.
• LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions.Oi C, Gidden Z, Holyoake L, Kantelberg O, Mochrie S, Horrocks MH, Regan L. Commun Biol. 2020 Aug 20; 2020 Aug 20. PMID: 32820217.
• Void distributions reveal structural link between jammed packings and protein cores.Treado JD, Mei Z, Regan L, O'Hern CS. Phys Rev E. 2019 Feb. PMID: 30934238.
• A threonine zipper that mediates protein-protein interactions: Structure and prediction.Oi C, Treado JD, Levine ZA, Lim CS, Knecht KM, Xiong Y, O'Hern CS, Regan L. Protein Sci. 2018 Nov. PMID: 30198622.
• The past, present and future of protein-based materials.Abascal NC, Regan L. Open Biol. 2018 Oct 31; 2018 Oct 31. PMID: 30381364.
• Flat Drops, Elastic Sheets, and Microcapsules by Interfacial Assembly of a Bacterial Biofilm Protein, BslA.Kaufman G, Liu W, Williams DM, Choo Y, Gopinadhan M, Samudrala N, Sarfati R, Yan ECY, Regan L, Osuji CO. Langmuir. 2017 Nov 28; 2017 Nov 15. PMID: 29094950.
• Intensification: A Resource for Amplifying Population-Genetic Signals with Protein Repeats.Chen J, Wang B, Regan L, Gerstein M. J Mol Biol. 2017 Feb 3; 2016 Dec 7. PMID: 27939289.
• Fabrication of Modularly Functionalizable Microcapsules Using Protein-Based Technologies.Schloss AC, Liu W, Williams DM, Kaufman G, Hendrickson HP, Rudshteyn B, Fu L, Wang H, Batista VS, Osuji C, Yan ECY, Regan L. ACS Biomater Sci Eng. 2016 Nov 14; 2016 Sep 21. PMID: 29805990.
• Promoting convergence: The integrated graduate program in physical and engineering biology at Yale University, a new model for graduate education.Noble DB, Mochrie SG, O'Hern CS, Pollard TD, Regan L. Biochem Mol Biol Educ. 2016 Nov 12; 2016 Jun 13. PMID: 27292366.
• Designed Proteins as Novel Imaging Reagents in Living Escherichia coli.Pratt SE, Speltz EB, Mochrie SG, Regan L. Chembiochem. 2016 Sep 2; 2016 Jul 26. PMID: 27304706.
• Understanding the physical basis for the side-chain conformational preferences of methionine.Virrueta A, O'Hern CS, Regan L. Proteins. 2016 Jul; 2016 Apr 6. PMID: 26917446.
• Protein engineering strategies with potential applications for altering clinically relevant cellular pathways at the protein level.Regan L, Hinrichsen MR, Oi C. Expert Rev Proteomics. 2016 May; 2016 Apr 25. PMID: 27031866.
• A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals.Chen J, Rozowsky J, Galeev TR, Harmanci A, Kitchen R, Bedford J, Abyzov A, Kong Y, Regan L, Gerstein M. Nat Commun. 2016 Apr 18; 2016 Apr 18. PMID: 27089393.
• Random close packing in protein cores.Gaines JC, Smith WW, Regan L, O'Hern CS. Phys Rev E. 2016 Mar; 2016 Mar 28. PMID: 27078398.
• Protein-Based Hydrogels for Tissue Engineering.Schloss AC, Williams DM, Regan LJ. Adv Exp Med Biol. 2016. PMID: 27677513.
• Reads meet rotamers: structural biology in the age of deep sequencing.Sethi A, Clarke D, Chen J, Kumar S, Galeev TR, Regan L, Gerstein M. Curr Opin Struct Biol. 2015 Dec; 2015 Dec 1. PMID: 26658741.
• A designed repeat protein as an affinity capture reagent.Speltz EB, Brown RS, Hajare HS, Schlieker C, Regan L. Biochem Soc Trans. 2015 Oct. PMID: 26517897.
• Design of Protein-Peptide Interaction Modules for Assembling Supramolecular Structures in Vivo and in Vitro.Speltz EB, Nathan A, Regan L. ACS Chem Biol. 2015 Sep 18; 2015 Jul 17. PMID: 26131725.
• Equilibrium transitions between side-chain conformations in leucine and isoleucine.Caballero D, Smith WW, O'Hern CS, Regan L. Proteins. 2015 Aug. PMID: 26018846.
• Protein design: Past, present, and future.Regan L, Caballero D, Hinrichsen MR, Virrueta A, Williams DM, O'Hern CS. Biopolymers. 2015 Jul. PMID: 25784145.
• Designed phosphoprotein recognition in Escherichia coli.Sawyer N, Gassaway BM, Haimovich AD, Isaacs FJ, Rinehart J, Regan L. ACS Chem Biol. 2014 Nov 21; 2014 Oct 6. PMID: 25272187.
• Predicting the side-chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models.Zhou AQ, O'Hern CS, Regan L. Proteins. 2014 Oct; 2014 Aug 11. PMID: 24912976.
• Routes to DNA accessibility: alternative pathways for nucleosome unwinding.Schlingman DJ, Mack AH, Kamenetska M, Mochrie SGJ, Regan L. Biophys J. 2014 Jul 15. PMID: 25028880.
• Intrinsic α-helical and β-sheet conformational preferences: a computational case study of alanine.Caballero D, Määttä J, Zhou AQ, Sammalkorpi M, O'Hern CS, Regan L. Protein Sci. 2014 Jul; 2014 May 9. PMID: 24753338.
• The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.Zhao Q, Saro D, Sachpatzidis A, Singh TR, Schlingman D, Zheng XF, Mack A, Tsai MS, Mochrie S, Regan L, Meetei AR, Sung P, Xiong Y. Nat Commun. 2014. PMID: 24390579.
• New insights into the interdependence between amino acid stereochemistry and protein structure.Zhou AQ, Caballero D, O'Hern CS, Regan L. Biophys J. 2013 Nov 19. PMID: 24268152.
• NextGen protein design.Sawyer N, Speltz EB, Regan L. Biochem Soc Trans. 2013 Oct. PMID: 24059497.
• Nanostructured functional films from engineered repeat proteins.Grove TZ, Regan L, Cortajarena AL. J R Soc Interface. 2013 Jun 6; 2013 Apr 17. PMID: 23594813.
• White and green screening with circular polymerase extension cloning for easy and reliable cloning.Speltz EB, Regan L. Protein Sci. 2013 Jun; 2013 May 8. PMID: 23592493.
• All repeats are not equal: a module-based approach to guide repeat protein design.Sawyer N, Chen J, Regan L. J Mol Biol. 2013 May 27; 2013 Feb 19. PMID: 23434848.
• Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area.Chen J, Sawyer N, Regan L. Protein Sci. 2013 Apr; 2013 Feb 26. PMID: 23389845.
• Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome.Mack AH, Schlingman DJ, Ilagan RP, Regan L, Mochrie SG. J Mol Biol. 2012 Nov 9; 2012 Aug 31. PMID: 22944905.
• A modular approach to the design of protein-based smart gels.Grove TZ, Forster J, Pimienta G, Dufresne E, Regan L. Biopolymers. 2012 Jul; 2012 Feb 10. PMID: 22328209.
• The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val.Zhou AQ, O'Hern CS, Regan L. Biophys J. 2012 May 16; 2012 May 15. PMID: 22677388.
• A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines.Pimienta G, Herbert KM, Regan L. Mol Pharm. 2011 Dec 5; 2011 Oct 5. PMID: 21882818.
• Revisiting the Ramachandran plot from a new angle.Zhou AQ, O'Hern CS, Regan L. Protein Sci. 2011 Jul; 2011 May 31. PMID: 21538644.
• Modulating repeat protein stability: the effect of individual helix stability on the collective behavior of the ensemble.Cortajarena AL, Mochrie SG, Regan L. Protein Sci. 2011 Jun; 2011 May 3. PMID: 21495096.
• A new method for the covalent attachment of DNA to a surface for single-molecule studies.Schlingman DJ, Mack AH, Mochrie SG, Regan L. Colloids Surf B Biointerfaces. 2011 Mar; 2010 Nov 9. PMID: 21130613.
• Calorimetric study of a series of designed repeat proteins: modular structure and modular folding.Cortajarena AL, Regan L. Protein Sci. 2011 Feb. PMID: 21280125.
• Stimuli-responsive smart gels realized via modular protein design.Grove TZ, Osuji CO, Forster JD, Dufresne ER, Regan L. J Am Chem Soc. 2010 Oct 13. PMID: 20860358.
• Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP.Kundrat L, Regan L. Biochemistry. 2010 Sep 7. PMID: 20704274.
• Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay.Jackrel ME, Cortajarena AL, Liu TY, Regan L. ACS Chem Biol. 2010 Jun 18. PMID: 20038141.
• Creating novel proteins by combining design and selection.Grove TZ, Hands M, Regan L. Protein Eng Des Sel. 2010 Jun; 2010 Mar 19. PMID: 20304973.
• A new bright green-emitting fluorescent protein--engineered monomeric and dimeric forms.Ilagan RP, Rhoades E, Gruber DF, Kao HT, Pieribone VA, Regan L. FEBS J. 2010 Apr; 2010 Mar 18. PMID: 20345907.
• Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand.Cortajarena AL, Wang J, Regan L. FEBS J. 2010 Feb; 2010 Jan 18. PMID: 20089039.
• Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP.Kundrat L, Regan L. J Mol Biol. 2010 Jan 22; 2009 Nov 12. PMID: 19913553.
• HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP.Yi F, Doudevski I, Regan L. Protein Sci. 2010 Jan. PMID: 19866486.
• Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering.Kajander T, Sachs JN, Goldman A, Regan L. J Biol Chem. 2009 Sep 11; 2009 Jul 7. PMID: 19586912.
• A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics.Champion EA, Kundrat L, Regan L, Baserga SJ. Protein Eng Des Sel. 2009 Jul; 2009 Jun 10. PMID: 19515729.
• Redesign of a protein-peptide interaction: characterization and applications.Jackrel ME, Valverde R, Regan L. Protein Sci. 2009 Apr. PMID: 19309728.
• An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction.Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. J Biomol Screen. 2009 Mar; 2009 Feb 11. PMID: 19211782.
• A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.Champion EA, Lane BH, Jackrel ME, Regan L, Baserga SJ. Mol Cell Biol. 2008 Nov; 2008 Aug 25. PMID: 18725399.
• A novel class of small molecule inhibitors of Hsp90.Yi F, Regan L. ACS Chem Biol. 2008 Oct 17; 2008 Sep 12. PMID: 18785742.
• Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state.Cortajarena AL, Lois G, Sherman E, O'Hern CS, Regan L, Haran G. J Mol Biol. 2008 Sep 26; 2008 Jul 11. PMID: 18644382.
• Ligand binding by repeat proteins: natural and designed.Grove TZ, Cortajarena AL, Regan L. Curr Opin Struct Biol. 2008 Aug; 2008 Jul 23. PMID: 18602006.
• Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchange.Cortajarena AL, Mochrie SG, Regan L. J Mol Biol. 2008 Jun 6; 2008 Feb 29. PMID: 18462750.
• Structure and function of KH domains.Valverde R, Edwards L, Regan L. FEBS J. 2008 Jun; 2008 Apr 15. PMID: 18422648.
• Designed TPR modules as novel anticancer agents.Cortajarena AL, Yi F, Regan L. ACS Chem Biol. 2008 Mar 20. PMID: 18355005.
• Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins.Dalal S, Canet D, Kaiser SE, Dobson CM, Regan L. Protein Eng Des Sel. 2008 Mar. PMID: 18299293.
• Fragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein.Valverde R, Pozdnyakova I, Kajander T, Venkatraman J, Regan L. Structure. 2007 Sep. PMID: 17850748.
• Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins.Kajander T, Cortajarena AL, Mochrie S, Regan L. Acta Crystallogr D Biol Crystallogr. 2007 Jul; 2007 Jun 15. PMID: 17582171.
• Ligand binding by TPR domains.Cortajarena AL, Regan L. Protein Sci. 2006 May. PMID: 16641492.
• Consensus design as a tool for engineering repeat proteins.Kajander T, Cortajarena AL, Regan L. Methods Mol Biol. 2006. PMID: 16957336.
• Reassembled GFP: detecting protein-protein interactions and protein expression patterns.Magliery TJ, Regan L. Methods Biochem Anal. 2006. PMID: 16342418.
• Sequence variation in ligand binding sites in proteins.Magliery TJ, Regan L. BMC Bioinformatics. 2005 Sep 30; 2005 Sep 30. PMID: 16194281.
• A twisted four-sheeted model for an amyloid fibril.Wang J, Gülich S, Bradford C, Ramirez-Alvarado M, Regan L. Structure. 2005 Sep. PMID: 16154085.
• A new folding paradigm for repeat proteins.Kajander T, Cortajarena AL, Main ER, Mochrie SG, Regan L. J Am Chem Soc. 2005 Jul 27. PMID: 16028928.
• Local and long-range stability in tandemly arrayed tetratricopeptide repeats.Main ER, Stott K, Jackson SE, Regan L. Proc Natl Acad Sci U S A. 2005 Apr 19; 2005 Apr 11. PMID: 15824314.
• New insights into Fragile X syndrome. Relating genotype to phenotype at the molecular level.Pozdnyakova I, Regan L. FEBS J. 2005 Feb. PMID: 15670167.
• Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.Magliery TJ, Wilson CG, Pan W, Mishler D, Ghosh I, Hamilton AD, Regan L. J Am Chem Soc. 2005 Jan 12. PMID: 15631464.
• The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold.Wilson CG, Kajander T, Regan L. FEBS J. 2005 Jan. PMID: 15634341.
• Detecting protein-protein interactions with GFP-fragment reassembly.Wilson CG, Magliery TJ, Regan L. Nat Methods. 2004 Dec. PMID: 16145770.
• Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motif.Magliery TJ, Regan L. J Mol Biol. 2004 Oct 22. PMID: 15465058.
• Combinatorial approaches to protein stability and structure.Magliery TJ, Regan L. Eur J Biochem. 2004 May. PMID: 15096198.
• Library approaches to biophysical problems.Magliery TJ, Regan L. Eur J Biochem. 2004 May. PMID: 15096197.
• Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins.Cortajarena AL, Kajander T, Pan W, Cocco MJ, Regan L. Protein Eng Des Sel. 2004 Apr; 2004 May 27. PMID: 15166314.
• A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics.Magliery TJ, Regan L. Protein Eng Des Sel. 2004 Jan. PMID: 14985540.
• The folding and design of repeat proteins: reaching a consensus.Main ER, Jackson SE, Regan L. Curr Opin Struct Biol. 2003 Aug. PMID: 12948778.
• Design of stable alpha-helical arrays from an idealized TPR motif.Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L. Structure. 2003 May. PMID: 12737816.
• Molten globules move into action.Regan L. Proc Natl Acad Sci U S A. 2003 Apr 1; 2003 Mar 25. PMID: 12657734.
• Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro.Ramírez-Alvarado M, Cocco MJ, Regan L. Protein Sci. 2003 Mar. PMID: 12592027.
• Does the location of a mutation determine the ability to form amyloid fibrils?Ramírez-Alvarado M, Regan L. J Mol Biol. 2002 Oct 11. PMID: 12368095.