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Michael Grome, a postdoctoral associate in molecular, cellular, and developmental biology at Yale and first author of the study, likened codons to three-letter words within a sentence in the genetic recipe for life.
“A lot of these words are equivalent, or synonymous,” Grome said. “We set out to add more ingredients for building proteins, so we took three of these words for ‘stop’ and made them one. Two words were removed, then we re-engineered the cell so they were ‘freed’ for new function. We then engineered a cell that recognized the word to say something new, to represent a new ingredient.”
- July 16, 2015
We would like to welcome Pree Sareen to the lab.
- February 03, 2015
We would like to welcome Dan Lajoie to the lab.
- November 03, 2014Source: Current Biology
We would like to announce Michael Kunst's new paper Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila
- April 21, 2014
Congratulations to Alex Buhimschi, who received a Yale College Freshman Summer Research Fellowship to support him in the lab this summer!
- February 16, 2014
Screening more than 100 spider toxins, Yale researchers identified a protein from the venom of the Peruvian green velvet tarantula that blunts activity in pain-transmitting neurons. The findings, reported in the March 3 issue of the journal Current Biology, show the new screening method used by the scientists has the potential to search millions of different spider toxins for safe pain-killing drugs and therapies.
- February 16, 2014Source: The New York Times
"Toxineering," a new method developed by investigators at the Kavli Institute for Neuroscience at Yale, may be used to screen millions of spider toxins for safe pain-killing drugs and therapies. With it, Michael Nitabach and his colleagues have identified a protein from the venom of the Peruvian green velvet tarantula that targets an ion channel linked to neuropathic pain.
- August 15, 2013Source: Yale News
Yale researchers have discovered a new technique that allows them to measure electrical activity of genetically-targeted sets of neurons in a living organism, a prerequisite for understanding the complex language of the brain. The technique, described in the Aug. 8 issue of the journal Cell, involves inserting fluorescent proteins in neurons of a fruitfly that responds to changes in electrical signals and are recorded by optical sensors.
- August 08, 2013
School of Medicine researchers have developed a new technique that allows them to non-invasively and simultaneously measure electrical activity in many neurons in a living organism, a prerequisite for understanding the complex language of the brain. The technique, described in the Aug. 8 issue of the journal Cell, involves inserting a fluorescent protein that varies in intensity in response to changes in electrical signals into neurons and recording the changing light with optical sensors.
- June 04, 2013Source: Hughes Lab
Congratulations and farewell to Michael Hughes, who is starting his own lab as Assistant Professor at University of Missouri, St. Louis!