Publications

• Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs.Wang T, Ling AH, Billings SE, Hosseini DK, Vaisbuch Y, Kim GS, Atkinson PJ, Sayyid ZN, Aaron KA, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore LS, Maria PS, Blevins NH, Jackler RK, Alyono JC, Kveton J, Navaratnam D, Heller S, Lopez IA, Grillet N, Jan TA, Cheng AG. Nat Commun. 2024 Jun 6; 2024 Jun 6. PMID: 38844821.
• Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis.Guillen-Guio B, Paynton ML, Allen RJ, Chin DPW, Donoghue LJ, Stockwell A, Leavy OC, Hernandez-Beeftink T, Reynolds C, Cullinan P, Martinez F, Booth HL, Fahy WA, Hall IP, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Sayers I, Tobin MD, Whyte MKB, Adegunsoye A, Kaminski N, Ma SF, Strek ME, Zhang Y, Fingerlin TE, Molina-Molina M, Neighbors M, Sheng XR, Oldham JM, Maher TM, Molyneaux PL, Flores C, Noth I, Schwartz DA, Yaspan BL, Jenkins RG, Wain LV, Hollox EJ. ERJ Open Res. 2024 Jan; 2024 Feb 19. PMID: 38375425.
• Reply to "Considering Health Systems Worldwide: Point of View From a Middle-Income Country".Tu LH, Melnick E, Venkatesh AK, Sheth KN, Navaratnam D, Yaesoubi R, Forman HP, Mahajan A. AJR Am J Roentgenol. 2024 Feb; 2024 Feb 28. PMID: 38294162.
• Cost-Effectiveness of CT, CTA, MRI, and Specialized MRI for Evaluation of Patients Presenting to the Emergency Department With Dizziness.Tu LH, Melnick E, Venkatesh AK, Sheth KN, Navaratnam D, Yaesoubi R, Forman HP, Mahajan A. AJR Am J Roentgenol. 2024 Feb; 2023 Nov 8. PMID: 37937837.
• Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis.Leavy OC, Goemans AF, Stockwell AD, Allen RJ, Guillen-Guio B, Hernandez-Beeftink T, Adegunsoye A, Booth HL, Cullinan P, Fahy WA, Fingerlin TE, Virk HS, Hall IP, Hart SP, Hill MR, Hirani N, Hubbard RB, Kaminski N, Ma SF, McAnulty RJ, Sheng XR, Millar AB, Molina-Molina M, Navaratnam V, Neighbors M, Parfrey H, Saini G, Sayers I, Strek ME, Tobin MD, Whyte MK, Zhang Y, Maher TM, Molyneaux PL, Oldham JM, Yaspan BL, Flores C, Martinez F, Reynolds CJ, Schwartz DA, Noth I, Jenkins RG, Wain LV. medRxiv. 2024 Jan 15; 2024 Jan 15. PMID: 38293162.
• CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.Tu LH, Navaratnam D, Melnick ER, Forman HP, Venkatesh AK, Malhotra A, Yaesoubi R, Sureshanand S, Sheth KN, Mahajan A. AJR Am J Roentgenol. 2023 Dec; 2023 Jul 5. PMID: 37404082.
• Association study of human leukocyte antigen (HLA) variants and idiopathic pulmonary fibrosis.Guillen-Guio B, Paynton ML, Allen RJ, Chin DPW, Donoghue LJ, Stockwell A, Leavy OC, Hernandez-Beeftink T, Reynolds C, Cullinan P, Martinez F, Booth HL, Fahy WA, Hall IP, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Sayers I, Tobin MD, Whyte MKB, Adegunsoye A, Kaminski N, Shwu-Fan M, Strek ME, Zhang Y, Fingerlin TE, Molina-Molina M, Neighbors M, Sheng XR, Oldham JM, Maher TM, Molyneaux PL, Flores C, Noth I, Schwartz DA, Yaspan BL, Jenkins RG, Wain LV, Hollox EJ. medRxiv. 2023 Jul 24; 2023 Jul 24. PMID: 37546732.
• Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.Santos-Sacchi J, Bai JP, Navaratnam D. J Neurosci. 2023 Apr 5; 2023 Mar 3. PMID: 36868859.
• Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness.Tu LH, Malhotra A, Venkatesh AK, Taylor RA, Sheth KN, Yaesoubi R, Forman HP, Sureshanand S, Navaratnam D. PLoS One. 2023; 2023 Mar 9. PMID: 36893103.
• Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.Allen RJ, Oldham JM, Jenkins DA, Leavy OC, Guillen-Guio B, Melbourne CA, Ma SF, Jou J, Kim JS, Fahy WA, Oballa E, Hubbard RB, Navaratnam V, Braybrooke R, Saini G, Roach KM, Tobin MD, Hirani N, Whyte MKB, Kaminski N, Zhang Y, Martinez FJ, Linderholm AL, Adegunsoye A, Strek ME, Maher TM, Molyneaux PL, Flores C, Noth I, Gisli Jenkins R, Wain LV. Lancet Respir Med. 2023 Jan; 2022 Aug 16. PMID: 35985358.
• Outer hair cell function is normal in βV spectrin knockout mice.Stankewich MC, Bai JP, Stabach PR, Khan S, Tan WJT, Surguchev A, Song L, Morrow JS, Santos-Sacchi J, Navaratnam DS. Hear Res. 2022 Sep 15; 2022 Jul 3. PMID: 35864018.
• Physiology and biophysics of outer hair cells: The cells of Dallos.Santos-Sacchi J, Navaratnam D. Hear Res. 2022 Sep 15; 2022 May 16. PMID: 35599199.
• ISHLT consensus statement: Perioperative management of patients with pulmonary hypertension and right heart failure undergoing surgery.McGlothlin DP, Granton J, Klepetko W, Beghetti M, Rosenzweig EB, Corris PA, Horn E, Kanwar MK, McRae K, Roman A, Tedford R, Badagliacca R, Bartolome S, Benza R, Caccamo M, Cogswell R, Dewachter C, Donahoe L, Fadel E, Farber HW, Feinstein J, Franco V, Frantz R, Gatzoulis M, Hwa Anne Goh C, Guazzi M, Hansmann G, Hastings S, Heerdt PM, Hemnes A, Herpain A, Hsu CH, Kerr K, Kolaitis NA, Kukreja J, Madani M, McCluskey S, McCulloch M, Moser B, Navaratnam M, Rådegran G, Reimer C, Savale L, Shlobin OA, Svetlichnaya J, Swetz K, Tashjian J, Thenappan T, Vizza CD, West S, Zuckerman W, Zuckermann A, De Marco T. J Heart Lung Transplant. 2022 Sep; 2022 Jun 23. PMID: 36123001.
• Pilot MRI-based strategies to improve the detection of stroke in patients with dizziness/vertigo.Tu LH, Mahajan A, Minja FJ, Navaratnam D, Melnick ER. Clin Imaging. 2022 Feb; 2021 Dec 9. PMID: 34902799.
• Single particle cryo-EM structure of the outer hair cell motor protein prestin.Butan C, Song Q, Bai JP, Tan WJT, Navaratnam D, Santos-Sacchi J. Nat Commun. 2022 Jan 12; 2022 Jan 12. PMID: 35022426.
• Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea.Xue N, Song L, Song Q, Santos-Sacchi J, Wu H, Navaratnam D. Hear Res. 2021 Oct; 2021 Sep 4. PMID: 34536825.
• State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.Santos-Sacchi J, Navaratnam D, Tan WJT. Sci Rep. 2021 Aug 9; 2021 Aug 9. PMID: 34373481.
• Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients.McAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Stroke. 2021 Jun; 2021 May 10. PMID: 33966492.
• Efferent feedback controls bilateral auditory spontaneous activity.Wang Y, Sanghvi M, Gribizis A, Zhang Y, Song L, Morley B, Barson DG, Santos-Sacchi J, Navaratnam D, Crair M. Nat Commun. 2021 Apr 27; 2021 Apr 27. PMID: 33907194.
• Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic.Jasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR 3rd, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke. 2020 Sep; 2020 Jul 31. PMID: 32755347.
• Author Correction: Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti.Bai JP, Navaratnam D, Santos-Sacchi J. Sci Rep. 2020 Aug 27; 2020 Aug 27. PMID: 32848168.
• Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation.Bai JP, Xue N, Lawal O, Nyati A, Santos-Sacchi J, Navaratnam D. Physiol Rep. 2020 Aug. PMID: 32748549.
• Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion.Zhai F, Song L, Bai JP, Dai C, Navaratnam D, Santos-Sacchi J. Neuroscience. 2020 Apr 1; 2020 Feb 13. PMID: 32061780.
• Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD Jr, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV. Am J Respir Crit Care Med. 2020 Mar 1. PMID: 31710517.
• Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti.Bai JP, Navaratnam D, Santos-Sacchi J. Sci Rep. 2019 Nov 11; 2019 Nov 11. PMID: 31712635.
• Seeing the long tail: A novel green fluorescent protein, SiriusGFP, for ultra long timelapse imaging.Zhong S, Rivera-Molina F, Rivetta A, Toomre D, Santos-Sacchi J, Navaratnam D. J Neurosci Methods. 2019 Feb 1; 2018 Dec 19. PMID: 30578868.
• Teaching Video NeuroImages: Vestibulo-ocular reflex defect in cerebellar stroke.Witsch J, Ferrer M, Navaratnam D. Neurology. 2018 Aug 28. PMID: 30150275.
• Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.Tan WJT, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV. Antioxid Redox Signal. 2017 Sep 10; 2017 Mar 9. PMID: 28135838.
• Current carried by the Slc26 family member prestin does not flow through the transporter pathway.Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D. Sci Rep. 2017 Apr 19; 2017 Apr 19. PMID: 28422190.
• Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545877.
• Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK. Cell. 2016 Apr 7; 2016 Mar 17. PMID: 26997484.
• Yeast Two-Hybrid Screening to Test for Protein-Protein Interactions in the Auditory System.Moeini-Naghani I, Navaratnam DS. Methods Mol Biol. 2016. PMID: 27259923.
• Tyrosine motifs are required for prestin basolateral membrane targeting.Zhang Y, Moeini-Naghani I, Bai J, Santos-Sacchi J, Navaratnam DS. Biol Open. 2015 Jan 16; 2015 Jan 16. PMID: 25596279.
• A genetically-encoded YFP sensor with enhanced chloride sensitivity, photostability and reduced ph interference demonstrates augmented transmembrane chloride movement by gerbil prestin (SLC26a5).Zhong S, Navaratnam D, Santos-Sacchi J. PLoS One. 2014; 2014 Jun 5. PMID: 24901231.
• Real time measures of prestin charge and fluorescence during plasma membrane trafficking reveal sub-tetrameric activity.Bian S, Navaratnam D, Santos-Sacchi J. PLoS One. 2013; 2013 Jun 10. PMID: 23762468.
• Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation.Surguchev A, Bai JP, Joshi P, Navaratnam D. Am J Physiol Cell Physiol. 2012 Jul 15; 2012 Apr 25. PMID: 22538239.
• CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.Bai JP, Surguchev A, Joshi P, Gross L, Navaratnam D. Am J Physiol Cell Physiol. 2012 Mar 1; 2011 Nov 16. PMID: 22094329.
• Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.Frucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. J Assoc Res Otolaryngol. 2011 Aug; 2011 Mar 12. PMID: 21399991.
• MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium.Frucht CS, Santos-Sacchi J, Navaratnam DS. Neurosci Lett. 2011 Apr 8; 2011 Feb 21. PMID: 21316421.
• β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells.Bai JP, Surguchev A, Navaratnam D. Am J Physiol Cell Physiol. 2011 Mar; 2010 Dec 22. PMID: 21178105.
• Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression.Bian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ, Navaratnam DS. PLoS One. 2011; 2011 Dec 14. PMID: 22194818.
• A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events.Bian S, Koo BW, Kelleher S, Santos-Sacchi J, Navaratnam DS. Am J Physiol Cell Physiol. 2010 Oct; 2010 Jul 14. PMID: 20631244.
• Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation.Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. PLoS One. 2010 Jul 9; 2010 Jul 9. PMID: 20634979.
• Combinatorial cysteine mutagenesis reveals a critical intramonomer role for cysteines in prestin voltage sensing.Bai JP, Surguchev A, Bian S, Song L, Santos-Sacchi J, Navaratnam D. Biophys J. 2010 Jul 7. PMID: 20655836.
• Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein.Bai JP, Surguchev A, Ogando Y, Song L, Bian S, Santos-Sacchi J, Navaratnam D. J Biol Chem. 2010 Jul 2; 2010 Apr 23. PMID: 20418376.
• Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK. Nat Neurosci. 2010 Jul; 2010 May 30. PMID: 20512134.
• Prestin's anion transport and voltage-sensing capabilities are independent.Bai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Biophys J. 2009 Apr 22. PMID: 19383462.
• Yeast two-hybrid screening to test for protein-protein interactions in the auditory system.Navaratnam DS. Methods Mol Biol. 2009. PMID: 18839352.
• En block C-terminal charge cluster reversals in prestin (SLC26A5): effects on voltage-dependent electromechanical activity.Bai JP, Navaratnam D, Samaranayake H, Santos-Sacchi J. Neurosci Lett. 2006 Sep 1; 2006 Jul 12. PMID: 16839688.
• On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin.Santos-Sacchi J, Rybalchenko V, Bai JP, Song L, Navaratnam D. Pflugers Arch. 2006 Jun; 2006 Mar 7. PMID: 16521020.
• N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.Navaratnam D, Bai JP, Samaranayake H, Santos-Sacchi J. Biophys J. 2005 Nov; 2005 Aug 19. PMID: 16113116.
• Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradients.Samaranayake H, Saunders JC, Greene MI, Navaratnam DS. J Physiol. 2004 Oct 1; 2004 Jul 22. PMID: 15272029.