Publications

• Targeting hypoxia and thrombospondin-2 in diabetic wound healing.Huang Y, Xing H, Naud S, Kyriakides TR. FASEB J. 2024 Oct 15. PMID: 39383062.
• Bone-derived extracellular matrix hydrogel from thrombospondin-2 knock-out mice for bone repair.Chen Z, Zhang J, Lee FY, Kyriakides TR. Acta Biomater. 2024 Sep 15; 2024 Aug 10. PMID: 39134130.
• Photosensitive Nanoprobes for Rapid Isolation and Size-Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations.Weerakkody JS, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides TR, Gunasekara RW, Ramakrishnan S. Adv Funct Mater. 2024 Aug 22; 2024 Mar 29. PMID: 39372670.
• Editorial: Modulation of the Immune System to Improve Tissue Regeneration Strategies.Bracaglia LG, Kyriakides TR. Tissue Eng Part A. 2024 Apr; 2024 Mar 6. PMID: 38451538.
• Novel muscle-derived extracellular matrix hydrogel promotes angiogenesis and neurogenesis in volumetric muscle loss.Chen Z, Huang Y, Xing H, Tseng T, Edelman H, Perry R, Kyriakides TR. Matrix Biol. 2024 Mar; 2024 Feb 6. PMID: 38325441.
• Author Correction: Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction.Xing H, Huang Y, Kunkemoeller BH, Dahl PJ, Muraleetharan O, Malvankar NS, Murrell MP, Kyriakides TR. Sci Rep. 2023 Mar 14; 2023 Mar 14. PMID: 36918662.
• Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction.Xing H, Huang Y, Kunkemoeller BH, Dahl PJ, Muraleetharan O, Malvankar NS, Murrell MP, Kyriakides TR. Sci Rep. 2022 Dec 28; 2022 Dec 28. PMID: 36577792.
• Treating 'Septic' With Enhanced Antibiotics and 'Arthritis' by Mitigation of Excessive Inflammation.Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Front Cell Infect Microbiol. 2022; 2022 Jun 9. PMID: 35755835.
• Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.Kyriakides TR, Kim HJ, Zheng C, Harkins L, Tao W, Deschenes E. Biomed Mater. 2022 Mar 4; 2022 Mar 4. PMID: 35168213.
• Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.Liu B, Zhou H, Zhang T, Gao X, Tao B, Xing H, Zhuang Z, Dardik A, Kyriakides TR, Goodwin JE. Angiogenesis. 2021 Aug; 2021 Mar 2. PMID: 33650028.
• Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells.Dash BC, Duan K, Kyriakides TR, Hsia HC. Biomater Sci. 2021 Jul 27. PMID: 34190227.
• Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis.Kwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Sci Adv. 2021 Jun; 2021 Jun 25. PMID: 34172438.
• Biocompatibility of platinum-based bulk metallic glass in orthopedic applications.Loye AM, Kwon HK, Dellal D, Ojeda R, Lee S, Davis R, Nagle N, Doukas PG, Schroers J, Lee FY, Kyriakides TR. Biomed Mater. 2021 May 7; 2021 May 7. PMID: 33873168.
• Biocompatibility of nanomaterials and their immunological properties.Kyriakides TR, Raj A, Tseng TH, Xiao H, Nguyen R, Mohammed FS, Halder S, Xu M, Wu MJ, Bao S, Sheu WC. Biomed Mater. 2021 Mar 11; 2021 Mar 11. PMID: 33578402.
• Locally delivered adjuvant biofilm-penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection.Cahill SV, Kwon HK, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Kyriakides TR, Lee FY. J Orthop Res. 2021 Feb; 2021 Jan 13. PMID: 33336805.
• An in situ collagen-HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC-derived vascular smooth muscle cells.Dash BC, Duan K, Xing H, Kyriakides TR, Hsia HC. Biotechnol Bioeng. 2020 Dec; 2020 Aug 15. PMID: 32770746.
• Extracellular matrix-derived biomaterials in engineering cell function.Xing H, Lee H, Luo L, Kyriakides TR. Biotechnol Adv. 2020 Sep-Oct; 2019 Aug 2. PMID: 31381963.
• The role of extracellular matrix in the pathophysiology of diabetic wounds.Huang Y, Kyriakides TR. Matrix Biol Plus. 2020 May; 2020 Apr 22. PMID: 33543031.
• Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR. Diabetes. 2019 Oct; 2019 Aug 7. PMID: 31391172.
• Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR. Matrix Biol. 2019 Sep; 2019 Mar 13. PMID: 30876926.
• Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization.Shayan M, Padmanabhan J, Morris AH, Cheung B, Smith R, Schroers J, Kyriakides TR. Acta Biomater. 2018 Jul 15; 2018 Jun 1. PMID: 29859902.
• Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds.Morris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR. Biomaterials. 2018 Jul; 2018 Mar 29. PMID: 29631168.
• Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass.Loye AM, Kinser ER, Bensouda S, Shayan M, Davis R, Wang R, Chen Z, Schwarz UD, Schroers J, Kyriakides TR. Sci Rep. 2018 Jun 8; 2018 Jun 8. PMID: 29884812.
• Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC. Arterioscler Thromb Vasc Biol. 2018 Apr; 2018 Feb 15. PMID: 29449333.
• HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR. Matrix Biol. 2018 Jan; 2017 Aug 5. PMID: 28789925.
• Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition.Kunkemoeller B, Kyriakides TR. Antioxid Redox Signal. 2017 Oct 20; 2017 Aug 10. PMID: 28699352.
• Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Biomaterials. 2017 Oct; 2017 Jun 22. PMID: 28667900.
• Multicompartment Drug Release System for Dynamic Modulation of Tissue Responses.Morris AH, Mahal RS, Udell J, Wu M, Kyriakides TR. Adv Healthc Mater. 2017 Oct; 2017 Jun 21. PMID: 28636088.
• Exploring a wider range of Mg-Ca-Zn metallic glass as biocompatible alloys using combinatorial sputtering.Li J, Gittleson FS, Liu Y, Liu J, Loye AM, McMillon-Brown L, Kyriakides TR, Schroers J, Taylor AD. Chem Commun (Camb). 2017 Jul 20. PMID: 28665424.
• A hidden structural vulnerability in the thrombospondin-2 deficient aorta increases the propensity to intramural delamination.Bellini C, Kristofik NJ, Bersi MR, Kyriakides TR, Humphrey JD. J Mech Behav Biomed Mater. 2017 Jul; 2017 Mar 9. PMID: 28412645.
• The host response to naturally-derived extracellular matrix biomaterials.Morris AH, Stamer DK, Kyriakides TR. Semin Immunol. 2017 Feb; 2017 Mar 6. PMID: 28274693.
• Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR. Blood. 2016 Sep 22; 2016 Jul 28. PMID: 27471233.
• Regulation of cell-cell fusion by nanotopography.Padmanabhan J, Augelli MJ, Cheung B, Kinser ER, Cleary B, Kumar P, Wang R, Sawyer AJ, Li R, Schwarz UD, Schroers J, Kyriakides TR. Sci Rep. 2016 Sep 12; 2016 Sep 12. PMID: 27615159.
• New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx.Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE. Arterioscler Thromb Vasc Biol. 2016 Sep; 2016 Jul 7. PMID: 27386939.
• Inadequate Processing of Decellularized Dermal Matrix Reduces Cell Viability In Vitro and Increases Apoptosis and Acute Inflammation In Vivo.Morris AH, Chang J, Kyriakides TR. Biores Open Access. 2016; 2016 Jul 1. PMID: 27500014.
• Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses.Liu Y, Padmanabhan J, Cheung B, Liu J, Chen Z, Scanley BE, Wesolowski D, Pressley M, Broadbridge CC, Altman S, Schwarz UD, Kyriakides TR, Schroers J. Sci Rep. 2016 May 27; 2016 May 27. PMID: 27230692.
• Nanoparticle delivery of miR-223 to attenuate macrophage fusion.Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Biomaterials. 2016 May; 2016 Feb 26. PMID: 26967647.
• Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.Sawyer AJ, Kyriakides TR. Adv Drug Deliv Rev. 2016 Feb 1; 2016 Jan 4. PMID: 26763408.
• Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sites.Papanna R, Mann LK, Tseng SC, Stewart RJ, Kaur SS, Swindle MM, Kyriakides TR, Tatevian N, Moise KJ Jr. Placenta. 2015 Aug; 2015 May 30. PMID: 26059341.
• Nanomaterials, inflammation, and tissue engineering.Padmanabhan J, Kyriakides TR. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 May-Jun; 2014 Nov 25. PMID: 25421333.
• Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels.Swartzlander MD, Blakney AK, Amer LD, Hankenson KD, Kyriakides TR, Bryant SJ. Biomaterials. 2015 Feb; 2014 Dec 5. PMID: 25522967.
• Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics.Swartzlander MD, Barnes CA, Blakney AK, Kaar JL, Kyriakides TR, Bryant SJ. Biomaterials. 2015 Feb; 2014 Dec 2. PMID: 25522962.
• Click-coated, heparinized, decellularized vascular grafts.Dimitrievska S, Cai C, Weyers A, Balestrini JL, Lin T, Sundaram S, Hatachi G, Spiegel DA, Kyriakides TR, Miao J, Li G, Niklason LE, Linhardt RJ. Acta Biomater. 2015 Feb; 2014 Nov 20. PMID: 25463496.
• Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299.
• Molecular Characterization of Macrophage-Biomaterial Interactions.Moore LB, Kyriakides TR. Adv Exp Med Biol. 2015. PMID: 26306446.
• Angiogenesis and Vasculogenesis in Health and Disease.D'Alessio A, Moccia F, Li JH, Micera A, Kyriakides TR. Biomed Res Int. 2015; 2015 Jun 10. PMID: 26171386.
• Loss of monocyte chemoattractant protein-1 alters macrophage polarization and reduces NFκB activation in the foreign body response.Moore LB, Sawyer AJ, Charokopos A, Skokos EA, Kyriakides TR. Acta Biomater. 2015 Jan; 2014 Sep 19. PMID: 25242651.
• Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137.
• The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation.Sawyer AJ, Tian W, Saucier-Sawyer JK, Rizk PJ, Saltzman WM, Bellamkonda RV, Kyriakides TR. Biomaterials. 2014 Aug; 2014 May 29. PMID: 24881026.
• Thrombospondin-2 and extracellular matrix assembly.Calabro NE, Kristofik NJ, Kyriakides TR. Biochim Biophys Acta. 2014 Aug; 2014 Jan 15. PMID: 24440155.
• Matricellular proteins and biomaterials.Morris AH, Kyriakides TR. Matrix Biol. 2014 Jul; 2014 Mar 20. PMID: 24657843.
• Engineering cellular response using nanopatterned bulk metallic glass.Padmanabhan J, Kinser ER, Stalter MA, Duncan-Lewis C, Balestrini JL, Sawyer AJ, Schroers J, Kyriakides TR. ACS Nano. 2014 May 27; 2014 Apr 17. PMID: 24724817.
• A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model.Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. Int J Pharm. 2013 Sep 10; 2013 May 29. PMID: 23727592.
• An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds.Kobsa S, Kristofik NJ, Sawyer AJ, Bothwell AL, Kyriakides TR, Saltzman WM. Biomaterials. 2013 May; 2013 Feb 27. PMID: 23453058.
• Nanoparticle-based evaluation of blood-brain barrier leakage during the foreign body response.Sawyer AJ, Kyriakides TR. J Neural Eng. 2013 Feb; 2013 Jan 21. PMID: 23337399.
• Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Proc Natl Acad Sci U S A. 2011 Dec 13; 2011 Nov 22. PMID: 22109549.
• Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR. Proc Natl Acad Sci U S A. 2011 Nov 15; 2011 Sep 26. PMID: 21949402.
• Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters.Liu J, Jiang Z, Zhang S, Liu C, Gross RA, Kyriakides TR, Saltzman WM. Biomaterials. 2011 Sep. PMID: 21641030.
• Astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier.Tian W, Sawyer A, Kocaoglu FB, Kyriakides TR. Am J Pathol. 2011 Aug; 2011 Jun 23. PMID: 21704005.
• Lack of TNF-α-induced MMP-9 production and abnormal E-cadherin redistribution associated with compromised fusion in MCP-1-null macrophages.Skokos EA, Charokopos A, Khan K, Wanjala J, Kyriakides TR. Am J Pathol. 2011 May. PMID: 21514443.
• CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.Zhou J, Tang PC, Qin L, Gayed PM, Li W, Skokos EA, Kyriakides TR, Pober JS, Tellides G. J Exp Med. 2010 Aug 30; 2010 Aug 23. PMID: 20733031.
• Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization.Jay SM, Shepherd BR, Andrejecsk JW, Kyriakides TR, Pober JS, Saltzman WM. Biomaterials. 2010 Apr; 2010 Jan 27. PMID: 20110124.
• Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models.Jay SM, Skokos EA, Zeng J, Knox K, Kyriakides TR. J Biomed Mater Res A. 2010 Apr. PMID: 19536825.
• Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling.Roh JD, Sawh-Martinez R, Brennan MP, Jay SM, Devine L, Rao DA, Yi T, Mirensky TL, Nalbandian A, Udelsman B, Hibino N, Shinoka T, Saltzman WM, Snyder E, Kyriakides TR, Pober JS, Breuer CK. Proc Natl Acad Sci U S A. 2010 Mar 9; 2010 Mar 5. PMID: 20207947.
• Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair.Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC. Proc Natl Acad Sci U S A. 2009 Oct 13; 2009 Sep 25. PMID: 19805174.
• Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1beta levels and leakage of the blood-brain barrier.Tian W, Kyriakides TR. Matrix Biol. 2009 Apr; 2009 Mar 3. PMID: 19264129.
• Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9.MacLauchlan S, Skokos EA, Meznarich N, Zhu DH, Raoof S, Shipley JM, Senior RM, Bornstein P, Kyriakides TR. J Leukoc Biol. 2009 Apr; 2009 Jan 13. PMID: 19141565.
• Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF.Maclauchlan S, Skokos EA, Agah A, Zeng J, Tian W, Davidson JM, Bornstein P, Kyriakides TR. J Histochem Cytochem. 2009 Apr; 2008 Nov 24. PMID: 19029404.
• Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis.Kyriakides TR, Wulsin D, Skokos EA, Fleckman P, Pirrone A, Shipley JM, Senior RM, Bornstein P. Matrix Biol. 2009 Mar; 2009 Jan 20. PMID: 19379668.
• Thrombospondin 2-null mice display an altered brain foreign body response to polyvinyl alcohol sponge implants.Tian W, Kyriakides TR. Biomed Mater. 2009 Feb; 2008 Nov 20. PMID: 19020342.
• Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis.Krady MM, Zeng J, Yu J, MacLauchlan S, Skokos EA, Tian W, Bornstein P, Sessa WC, Kyriakides TR. Am J Pathol. 2008 Sep; 2008 Aug 7. PMID: 18688033.
• Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model.Roh JD, Nelson GN, Brennan MP, Mirensky TL, Yi T, Hazlett TF, Tellides G, Sinusas AJ, Pober JS, Saltzman WM, Kyriakides TR, Breuer CK. Biomaterials. 2008 Apr; 2007 Dec 27. PMID: 18164056.
• Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation.Jay SM, Skokos E, Laiwalla F, Krady MM, Kyriakides TR. Am J Pathol. 2007 Aug; 2007 Jun 7. PMID: 17556592.