Chengyang Liu
Visiting Student 2019/20, Halene LabAbout
Research
Publications
2026
Epigenetic adaptation of beta cells across lifespan and disease
Manduchi E, Descamps H, Liu J, Schug J, Da T, Lahori D, El-Mekkoussi H, Lee M, Feleke E, Bernstein D, Liu C, Naji A, Glaser B, Kaestner K, Avrahami D. Epigenetic adaptation of beta cells across lifespan and disease. Nature Metabolism 2026, 8: 941-956. PMID: 42032110, PMCID: PMC13121019, DOI: 10.1038/s42255-026-01495-y.Peer-Reviewed Original ResearchDifferential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes
Mao X, Konigsberg J, Noorchashm N, Meng W, Knox J, Golden G, Hamilton J, Maxwell T, Liu C, Betts M, Willi S, Naji A, Hanley P, Prak E. Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes. Biomolecules 2026, 16: 500. PMID: 42072622, PMCID: PMC13113336, DOI: 10.3390/biom16040500.Peer-Reviewed Original ResearchSpatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
Medina-Serpas M, Brusko M, Golden G, Campbell-Thompson M, Rogers T, Reardon S, Posgai A, Bacher R, Prak E, Liu C, Kaestner K, Naji A, Betts M, McIntyre L, Atkinson M, Brusko T. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes. Cell Reports 2026, 45: 117144. PMID: 41875135, PMCID: PMC13202731, DOI: 10.1016/j.celrep.2026.117144.Peer-Reviewed Original ResearchSEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells
Zhu W, Pan L, Cui X, Russo A, Ray R, Pederson B, Wei X, Lin L, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval D, Lindberg I, Qi L, Reinert R. SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells. Nature Communications 2026, 17: 3202. PMID: 41741474, PMCID: PMC13057016, DOI: 10.1038/s41467-026-69928-6.Peer-Reviewed Original Research
2025
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Abedi M, Rai P, Zhou Y, Liu C, Johnson I, Chandra A, Fasolino M, Rostami S, Wang W, Min Z, Li Y, Yu M, Jay A, Lian V, Silverman M, Kaestner K, Naji A, Faryabi R, Vahedi G. Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes. Science Immunology 2025, 10: eadz0472-eadz0472. PMID: 41270190, PMCID: PMC12766627, DOI: 10.1126/sciimmunol.adz0472.Peer-Reviewed Original ResearchMolecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress
Hu X, Guo L, Toledo M, Sanchez P, Xie G, Liu C, Naji A, Irianto J, Roper M, Wang Y. Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress. Diabetes 2025, 74: 1825-1838. PMID: 40773375, PMCID: PMC12451085, DOI: 10.2337/db24-1038.Peer-Reviewed Original ResearchIntegrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals
D'Oliveira Albanus R, Zhang X, Zhao Z, Taylor H, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos M, Narisu N, Taylor L, Saavedra X, Liu X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins F, Parker S, Chen S. Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals. Cell Reports 2025, 44: 116065. PMID: 40737125, PMCID: PMC12477748, DOI: 10.1016/j.celrep.2025.116065.Peer-Reviewed Original ResearchChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation
Vandana J, Zhu J, Giani A, Zhang T, Lacko L, Leng D, Taylor D, Lee B, Han Z, Jiao T, Huang Y, Zhao M, Liu X, Chong A, Xue D, Meng Z, Xiang J, Pan C, Wang W, Naji A, Evans T, Liu J, Collins F, Liu C, Chen S. ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation. Cell Stem Cell 2025, 32: 1299-1307.e8. PMID: 40562034, PMCID: PMC12335368, DOI: 10.1016/j.stem.2025.06.002.Peer-Reviewed Original ResearchImmune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Golden G, Wu V, Hamilton J, Amses K, Shapiro M, Sada Japp A, Liu C, Pampena M, Kuri-Cervantes L, Knox J, Gardner J, Atkinson M, Brusko T, Luning Prak E, Kaestner K, Naji A, Betts M. Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset. Nature Communications 2025, 16: 4621. PMID: 40383826, PMCID: PMC12086209, DOI: 10.1038/s41467-025-59626-0.Peer-Reviewed Original Research
2024
β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation.
Flatt A, Matus A, Gallop R, Markmann E, Dalton-Bakes C, Peleckis A, Liu C, Naji A, Rickels M. β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation. Diabetes 2024, 74: 749-759. PMID: 39630971, PMCID: PMC12015140, DOI: 10.2337/db24-0729.Peer-Reviewed Original Research